Πλοήγηση ανά Θέμα "ANTIVIRAL ACTIVITY"
Αποτελέσματα 1-7 από 7
-
Branched-chain C-cyano pyranonucleosides: Synthesis of 3 '-C-cyano & 3 '-C-cyano-3 '-deoxy pyrimidine pyranonucleosides as novel cytotoxic agents
(2011)This report describes the total and facile synthesis of 3'-C-cyano & 3'-C-cyano-3'-deoxy pyrimidine pyranonucleosides. Reaction of 3-keto glucoside 1 with sodium cyanide gave the desired precursor 3-C-cyano-1,2:5,6-di-O- ... -
Fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-2-keto-beta-D-glucopyranosyl derivatives of N-4-benzoyl cytosine
(2007)1,2:5,6-Di-O-isopropylidene-ot-D-glucofuranose on mild oxidation, reduction, fluorination, and deisopropylidenation followed by acetylation gave peracetylated 3-deoxy-3-fluoro-D-glueopyranose. This was coupled with silylated ... -
Keto and Exomethylene Pyranonucleosides as Antitumor Agents
(2012)Nucleosides and their analogues take an important place in medicinal chemistry as the structural basis for the development of therapeutic agents. Recently, there has been a renewed interest in the synthesis of keto and ... -
Long-term respiratory follow-up of H1N1 infection
(2011)Background: The first case of 2009 pandemic influenza A (H1N1) virus infection was documented in our Hospital on 10th August 2009. Metdods and findings: Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) ... -
Stereoselective facile synthesis of 2 '-spiro pyrimidine pyranonucleosides via their key intermediate 2 '-C-cyano analogues. Evaluation of their bioactivity
(2014)A novel series of 2'-spiro pyrimidine pyranonucleosides has been designed and synthesized. Their precursors, 2'-C-cyano nucleosides 5a,b and 6a,b, were obtained by subjecting 1a,b to the sequence of selective protection ... -
Unsaturated dideoxy fluoro-ketopyranosyl nucleosides as new cytostatic agents: A convenient synthesis of 2,6-dideoxy-3-fluoro-4-keto-beta-D-glucopyranosyl analogues of uracil, 5-fluorouracil, thymine, N-4-benzoyl cytosine and N-6-benzoyl adenine
(2009)The beta-protected nucleosides of uracil (2a), 5-fluorouracil (2b), thymine (2c), N-4-benzoyl cytosine (2d) and N-6-benzoyl adenine (2e) were synthesized by condensation of the peracetylated 3-deoxy-3-fluoro-D-glucopyramose ... -
Unsaturated fluoro-ketopyranosyl nucleosides: Synthesis and biological evaluation of 3-fluoro-4-keto-beta-D-glucopyranosyl derivatives of N(4)-benzoyl cytosine and N(6)-benzoyl adenine
(2008)The protected beta-nucleosides 1-(2,4,6-tri-O-acetyl-3-deoxy-3-fluoro-beta-D-glucopyranosyl)-N(4)-benzoyl cytosine (2a) and 9-(2,4,6-tri-O-acetyl3-deoxy-3-fluoro-O-D-glucopyranosyl)-N6-benzoyl adenine (2b), were synthesized ...