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    • Erratum to A genome-wide association study identifies a common variant near the GPR22 gene as a new locus involved in prevalence and progression of osteoarthritis [Bone, 44S2 (2009) S224] 

      Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; van der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; van de Putte, T.; Rivadeneira, F.; Slagboom, E. P.; Styrkársdóttir, U.; Tsezou, A.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; van Meurs, J. B. J. (2010)

    • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22 

      Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; Van Der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Styrḱarsd́ottir, U.; Tsezou, A.; Van De Putte, T.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; Van Meurs, J. B. J. (2010)
      Objective. To identify novel genes involved in osteoarthritis (OA), by means of a genome-wide association study. Methods. We tested 500,510 single-nucleotide polymorphisms (SNPs) in 1,341 Dutch Caucasian OA cases and 3,496 ...

    • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study 

      Panoutsopoulou, K.; Southam, L.; Elliott, K. S.; Wrayner, N.; Zhai, G.; Beazley, C.; Thorleifsson, G.; Arden, N. K.; Carr, A.; Chapman, K.; Deloukas, P.; Doherty, M.; McCaskie, A.; Ollier, W. E. R.; Ralston, S. H.; Spector, T. D.; Valdes, A. M.; Wallis, G. A.; Wilkinson, J. M.; Arden, E.; Battley, K.; Blackburn, H.; Blanco, F. J.; Bumpstead, S.; Cupples, L. A.; Day-Williams, A. G.; Dixon, K.; Doherty, S. A.; Esko, T.; Evangelou, E.; Felson, D.; Gomez-Reino, J. J.; Gonzalez, A.; Gordon, A.; Gwilliam, R.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hunt, S. E.; Ioannidis, J. P. A.; Ingvarsson, T.; Jonsdottir, I.; Jonsson, H.; Keen, R.; Kerkhof, H. J. M.; Kloppenburg, M. G.; Koller, N.; Lakenberg, N.; Lane, N. E.; Lee, A. T.; Metspalu, A.; Meulenbelt, I.; Nevitt, M. C.; O'Neill, F.; Parimi, N.; Potter, S. C.; Rego-Perez, I.; Riancho, J. A.; Sherburn, K.; Slagboom, P. E.; Stefansson, K.; Styrkarsdottir, U.; Sumillera, M.; Swift, D.; Thorsteinsdottir, U.; Tsezou, A.; Uitterlinden, A. G.; van Meurs, J. B. J.; Watkins, B.; Wheeler, M.; Mitchell, S.; Zhu, Y.; Zmuda, J. M.; Zeggini, E.; Loughlin, J.; arc, Ogen Consortium (2011)
      Objectives The genetic aetiology of osteoarthritis has not yet been elucidated. To enable a well-powered genome-wide association study (GWAS) for osteoarthritis, the authors have formed the arcOGEN Consortium, a UK-wide ...

    • Large-Scale Analysis of Association Between GDF5 and FRZB Variants and Osteoarthritis of the Hip, Knee, and Hand 

      Evangelou, E.; Chapman, K.; Meulenbelt, I.; Karassa, F. B.; Loughlin, J.; Carr, A.; Doherty, M.; Doherty, S.; Gomez-Reino, J. J.; Gonzalez, A.; Halldorsson, B. V.; Hauksson, V. B.; Hofman, A.; Hart, D. J.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsdottir, I.; Jonsson, H.; Kerkhof, H. J. M.; Kloppenburg, M.; Lane, N. E.; Li, J.; Lories, R. J.; van Meurs, J. B. J.; Nakki, A.; Nevitt, M. C.; Rodriguez-Lopez, J.; Shi, D. Q.; Slagboom, E.; Stefansson, K.; Tsezou, A.; Wallis, G. A.; Watson, C. M.; Spector, T. D.; Uitterlinden, A. G.; Valdes, A. M.; Ioannidis, J. P. A. (2009)
      Objective. GDF5 and FRZB have been proposed as genetic loci conferring susceptibility to osteoarthritis (OA); however, the results of several studies investigating the association of OA with the rs143383 polymorphism of ...

    • Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22 

      Evangelou, E.; Valdes, A. M.; Kerkhof, H. J. M.; Styrkarsdottir, U.; Zhu, Y.; Meulenbelt, I.; Lories, R. J.; Karassa, F. B.; Tylzanowski, P.; Bos, S. D.; Rayner, N. W.; Southam, L.; Zhai, G.; Elliott, K. S.; Hunt, S. E.; Blackburn, H.; Potter, S. C.; Day-Williams, A. G.; Beazley, C.; Akune, T.; Arden, N. K.; Carr, A.; Chapman, K.; Cupples, L. A.; Dai, J.; Deloukas, P.; Doherty, M.; Doherty, S.; Engstrom, G.; Gonzalez, A.; Halldorsson, B. V.; Hammond, C. L.; Hart, D. J.; Helgadottir, H.; Hofman, A.; Ikegawa, S.; Ingvarsson, T.; Jiang, Q.; Jonsson, H.; Kaprio, J.; Kawaguchi, H.; Kisand, K.; Kloppenburg, M.; Kujala, U. M.; Lohmander, L. S.; Loughlin, J.; Luyten, F. P.; Mabuchi, A.; McCaskie, A.; Nakajima, M.; Nilsson, P. M.; Nishida, N.; Ollier, W. E. R.; Panoutsopoulou, K.; Van De Putte, T.; Ralston, S. H.; Rivadeneira, F.; Saarela, J.; Schulte-Merker, S.; Shi, D.; Slagboom, P. E.; Sudo, A.; Tamm, A.; Thorleifsson, G.; Thorsteinsdottir, U.; Tsezou, A.; Wallis, G. A.; Wilkinson, J. M.; Yoshimura, N.; Zeggini, E.; Zhang, F.; Jonsdottir, I.; Uitterlinden, A. G.; Felson, D. T.; Van Meurs, J. B.; Stefansson, K.; Ioannidis, J. P. A.; Spector, T. D. (2011)
      Objectives: Osteoarthritis (OA) is the most prevalent form of arthritis and accounts for substantial morbidity and disability, particularly in older people. It is characterised by changes in joint structure, including ...