Auflistung nach Autor "Gatter, K. C."
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Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
Koukourakis, M. I.; Giatromanolaki, A.; Fountzilas, G.; Sivridis, E.; Gatter, K. C.; Harris, A. L. (2000)Thymidine phosphorylase (TP), an enzyme involved in the thymidine synthesis and degradation, has been shown to promote tumor angiogenesis, Both TP expression and tumor vascularization are putative postoperative prognostic ... -
Angiogenic interactions of vascular endothelial growth factor, of thymidine phosphorylase, and of p53 protein expression in locally advanced gastric cancer
Giatromanolaki, A.; Koukourakis, M. I.; Stathopoulos, G. P.; Kapsoritakis, A.; Paspatis, G.; Kakolyris, S.; Sivridis, E.; Georgoulias, V.; Harris, A. L.; Gatter, K. C. (2000)The assessment of the angiogenic profile of tumors may become an important tool as a guide for the inclusion of novel drugs and molecular therapies into the standard chemoradiotherapy policy. Several studies have shown the ... -
The angiogenic pathway 'vascular endothelial growth factor/flk-I (KDR)-receptor' in rheumatoid arthritis and osteoarthritis
Giatromanolaki, A.; Sivridis, E.; Atanassou, N.; Zois, E.; Thorpe, P. E.; Brekken, R. A.; Gatter, K. C.; Harris, A. L.; Koukourakis, I. M.; Koukourakis, M. I. (2001)Active angiogenesis, together with an up-regulation of angiogenic factors, is evident in the synovium of both rheumatoid arthritis (RA) and osteoarthritis (OA). The present study assessed, by immunohistochemistry, the ... -
bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer
Koukourakis, M. I.; Giatromanolaki, A.; O'Byrne, K. J.; Cox, J.; Krammer, B.; Gatter, K. C.; Harris, A. L. (1999)Tumour angiogenesis has been recently recognised as one of the most important prognostic factors in lung cancer. Although a variety of angiogenic factors have been identified, the angiogenesis process remains poorly ... -
Coexpression of MUC1 glycoprotein with multiple angiogenic factors in non-small cell lung cancer suggests coactivation of angiogenic and migration pathways
Giatromanolaki, A.; Koukourakis, M. I.; Sivridis, E.; O'Byrne, K.; Cox, G.; Thorpe, P. E.; Gatter, K. C.; Harris, A. L. (2000)We investigated the expression of MUC1 protein and its relationship to the microvessel density and the expression of thymidine phosphorylase, vascular endothelial growth factor (VEGF), VEGF-receptor KDR, basic fibroblast ... -
Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy
Koukourakis, M. I.; Giatromanolaki, A.; Skarlatos, J.; Corti, L.; Blandamura, S.; Piazza, M.; Gatter, K. C.; Harris, A. L. (2001)Hypoxia inducible factor 1a and 2a (HIF-1a and HIF-2a) are key proteins regulating cellular response to hypoxia, Because the efficacy of photodynamic therapy (PDT) is dependent on the presence of oxygen, the assessment of ... -
'Invading edge vs. inner' (edvin) patterns of vascularization: an interplay between angiogenic and vascular survival factors defines the clinical behaviour of non-small cell lung cancer
Giatromanolaki, A.; Koukourakis, M. I.; Sivridis, E.; O'Byrne, K.; Gatter, K. C.; Harris, A. L. (2000)Neo-angiogenesis during neoplastic growth involves endothelial mitogenic and migration stimuli produced by cancer or tumour stromal cells. Although this active angiogenesis takes place in the tumour periphery, the process ... -
Thymidine phosphorylase expression in normal and hyperplastic endometrium
Sivridis, E.; Giatromanolaki, A.; Koukourakis I, M.; Bicknell, R.; Harris, A. L.; Gatter, K. C. (2000)Aims - To investigate the expression of thymidine phosphorylase (TP), a known angiogenic factor for endothelial cells, in normally cycling endometrium and various forms of endometrial hyperplasia. Methods - TP expression ...