Πλοήγηση ανά Συγγραφέα "Fountzilas, G."
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Angiogenesis and apoptosis-related protein (p53, bcl-2, and bax) expression versus response of gastric adenocarcinomas to paclitaxel and carboplatin chemotherapy
Giatromanolaki, A.; Stathopoulos, G. P.; Koukourakis, M. I.; Rigatos, S.; Vrettou, E.; Kittas, C.; Fountzilas, G.; Sivridis, E. (2001)The role of angiogenesis and apoptosis-related proteins in defining response to chemotherapy is poorly understood. We examined the microvessel density (MVD) and the expression of p53, bcl-2, and bax proteins in a series ... -
Angiogenesis, thymidine phosphorylase, and resistance of squamous cell head and neck cancer to cytotoxic and radiation therapy
Koukourakis, M. I.; Giatromanolaki, A.; Fountzilas, G.; Sivridis, E.; Gatter, K. C.; Harris, A. L. (2000)Thymidine phosphorylase (TP), an enzyme involved in the thymidine synthesis and degradation, has been shown to promote tumor angiogenesis, Both TP expression and tumor vascularization are putative postoperative prognostic ... -
Association of VEGF-A Splice Variant mRNA Expression With Outcome in Bevacizumab-Treated Patients With Metastatic Breast Cancer
Pentheroudakis, G.; Kotoula, V.; Kouvatseas, G.; Charalambous, E.; Dionysopoulos, D.; Zagouri, F.; Koutras, A.; Papazisis, K.; Pectasides, D.; Samantas, E.; Dimopoulos, M. A.; Papandreou, C. N.; Fountzilas, G. (2014)We studied tissue mRNA levels of VEGF-Axxxa angiogenic versus VEGF-Axxxb anti-angiogenic isoforms by means of specially designed PCR assays in two parallel cohorts of metastatic breast cancer patients, one treated with ... -
Bax protein expression in colorectal cancer: Association with p53, bcl-2 and patterns of relapse
Giatromanolaki, A.; Sivridis, E.; Stathopoulos, G. P.; Fountzilas, G.; Kalofonos, H. P.; Tsamandas, A.; Vrettou, E.; Scopa, C.; Polychronidis, A.; Simopoulos, K.; Koukourakis, M. I. (2001)This study evaluated the frequency and the prognostic significance of bax, bcl-2 and p53 proteins in stage B and C adenocarcinomas of the colon and rectum. Paraffin-embedded specimens from 268 patients with colorectal ... -
Docetaxel and Intermittent Erlotinib in Patients with Metastatic Non-small Cell Lung Cancer; A Phase II Study From The Hellenic Cooperative Oncology Group
Karavasilis, V.; Kosmidis, P.; Syrigos, K. N.; Mavropoulou, P.; Dimopoulos, M. A.; Kotoula, V.; Pectasides, D.; Boukovinas, I.; Klouvas, G.; Kalogera-Fountzila, A.; Papandreou, C. N.; Fountzilas, G.; Briasoulis, E. (2014)Aim: To determine the more effective dosing sequence of intermittent erlotinib and docetaxel for treating chemotherapy-naive patients with advanced Non-Small Cell Lung Cancer (NSCLC). Patients and Methods: Patients were ... -
Dose-dense sequential adjuvant chemotherapy followed, as indicated, by trastuzumab for one year in patients with early breast cancer: first report at 5-year median follow-up of a Hellenic Cooperative Oncology Group randomized phase III trial
Fountzilas, G.; Dafni, U.; Papadimitriou, C.; Timotheadou, E.; Gogas, H.; Eleftheraki, A. G.; Xanthakis, I.; Christodoulou, C.; Koutras, A.; Papandreou, C. N.; Papakostas, P.; Miliaras, S.; Markopoulos, C.; Dimitrakakis, C.; Korantzopoulos, P.; Karanikiotis, C.; Bafaloukos, D.; Kosmidis, P.; Samantas, E.; Varthalitis, I.; Pavlidis, N.; Pectasides, D.; Dimopoulos, M. A. (2014)Background: Dose-dense sequential chemotherapy including anthracyclines and taxanes has been established in the adjuvant setting of high-risk operable breast cancer. However, the preferable taxane and optimal schedule of ... -
Evaluation of Current Prognostic and Predictive Markers in Breast Cancer: A Validation Study of Tissue Microarrays
Batistatou, A.; Televantou, D.; Bobos, M.; Eleftheraki, A. G.; Kouvaras, E.; Chrisafi, S.; Koukoulis, G. K.; Malamou-Mitsi, V.; Fountzilas, G. (2013)Background: Tissue microarrays (TMAs) are an attractive alternative to analysis of whole sections (WS). For breast carcinomas, the recent recommendations for cut-offs (i.e. Ki67, H-score) have necessitated the re-evaluation ... -
Post-operative combined radiation and chemotherapy with temozolomide and irinotecan in patients with high-grade astrocytic tumors. A phase II study with biomarker evaluation
Fountzilas, G.; Karkavelas, G.; Kalogera-Fountzila, A.; Karina, M.; Ignatiadis, M.; Koukoulis, G.; Plataniotis, G.; Misailidou, D.; Bobos, M.; Pectasides, D.; Razis, E.; Karavelis, A.; Selviaridis, P. (2006)Background: Clinical studies have shown that temozolomide (TMZ) and irinotecan demonstrate activity in high grade astrocytic tumors (HGAT). However, the optimal schedule of administration is unknown. Patients and Methods: ... -
Primary extranodal non Hodgkin's lymphoma of the head and neck in adults: A clinicopathological comparison between tonsillar and non tonsillar lymphomas
Economopoulos, T.; Fountzilas, G.; Kostourou, A.; Daniilidis, J.; Pavlidis, N.; Andreopoulou, H.; Nicolaou, A.; Papageorgiou, E.; Mellou, S.; Dervenoulas, J.; Stathakis, N. (1998)Primary extranodal NHL of the head and neck (HN-NHL) accounts for 10-20% of all cases of NHL. Despite their frequency, the natural history and biological behaviour of these lymphomas is poorly understood. In this study we ... -
Prognostic impact of tumor volumetry in patients with locally advanced head-and-neck carcinoma (non-nasopharyngeal) treated by radiotherapy alone or combined radiochemotherapy in a randomized trial
Plataniotis, G. A.; Theofanopoulou, M. E.; Kalogera-Fountzila, A.; Haritanti, A.; Ciuleanou, E.; Ghilezan, N.; Zamboglou, N.; Dimitriadis, A.; Sofroniadis, I.; Fountzilas, G. (2004)Purpose: Tumor volume (TV) is one of the main reported factors determining the outcome of treatment in head-and-neck carcinomas. In this study, the prognostic impact of TV was explored in the context of a randomized trial ... -
Prospective, randomized phase III study comparing two intensified regimens (methotrexate/vinblastine/doxorubicin hydrochloride/cisplatin MVAC versus gemcitabine/cisplatin) in patients with inoperable or recurrent urothelial cancer
Bamias, A.; Karadimou, A.; Lampaki, S.; Aravantinos, G.; Xanthakis, I.; Papandreou, C.; Lainakis, G.; Zagouri, F.; Soupos, N.; Kostouros, E.; Samantas, E.; Hatzimouratidis, C.; Konstantinidis, C.; Deliveliotis, C.; Pectasides, D. G.; Fountzilas, G.; Dimopoulos, M. A.; Hellenic Cooperative Oncology, Grp (2011)