Πλοήγηση ανά Συγγραφέα "Bonanou, S."
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Analysis of molecules differentially interacting with the highly homologous ER-alpha corepressors safb1 and safb2
Tsianou, D.; Lyberopoulou, A.; Kohen, R.; Bonanou, S.; Georgatsou, E. (2006) -
Bacterially produced human HIF-1 alpha is competent for heterodimerization and specific DNA-binding
Chachami, G.; Paraskeva, E.; Georgatsou, E.; Bonanou, S.; Simos, G. (2005)Hypoxia-inducible factor 1α (HIF- 1α) is the regulatory Subunit of HIF- 1. the transcriptional activator and key mediator of the cellular response to hypoxia. Regulation of HIF-1α Occurs at multiple levels ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells
Befani, C. D.; Vlachostergios, P. J.; Hatzidaki, E.; Patrikidou, A.; Bonanou, S.; Simos, G.; Papandreou, C. N.; Liakos, P. (2012)Bortezomib represents the first proteasome inhibitor (PI) with demonstrated antitumor activity in the clinical setting, particularly for treatment of hematological malignancies. At the preclinical level, its action is shown ... -
Bortezomib represses HIF-1 alpha protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells (vol 90, pg 45, 2012)
Befani, C. D.; Vlachostergios, P. J.; Hatzidaki, E.; Patrikidou, A.; Bonanou, S.; Simos, G.; Papandreou, C. N.; Liakos, P. (2013) -
Cobalt induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) in HeLa cells by an iron-independent, but ROS-, PI-3K- and MAPK-dependent mechanism
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2006)The iron-chelator desferrioxamine (DFO) and the transition metal cobalt induce hypoxia-inducible factor-1 alpha (HIF-1 alpha) in normoxia. DFO stabilizes HIF-1 alpha from proteolysis by inhibiting the activity of iron-dependent ... -
Cobalt induces hypoxia-inducible factor-1 alpha expression in airway smooth muscle cells by a reactive oxygen species- and PI3K-dependent mechanism
Chachami, G.; Simos, G.; Hatziefthimiou, A.; Bonanou, S.; Molyvdas, P. A.; Paraskeva, E. (2004)Cobalt can mimic hypoxia and has been implicated as a cause of lung defects. However, the effect of cobalt on airway smooth muscle (ASM) cells has not been analyzed in detail. In this article, we use primary cultures of ... -
Detection of new molecular partners of hypoxia inducible factor 1 alpha (HIF-1 alpha)
Lyberopoulou, A.; Gadaras, G.; Venieris, E.; Chachami, G.; Simos, G.; Bonanou, S.; Georgatsou, E. (2005) -
Differential regulation of hypoxia inducible factor 1 alpha (HIF-1 alpha) expression and HeLa cell survival and proliferation by hypoxia, desferrioxamine, cobalt and quercetin: the role of iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2005) -
The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2
Tsianou, D.; Nikolakaki, E.; Tzitzira, A.; Bonanou, S.; Giannakouros, T.; Georgatsou, E. (2009)SR protein kinases (SRPKs) phosphorylate Ser/Arg dipeptide-containing proteins that play crucial roles in a broad spectrum of basic cellular processes. Phosphorylation by SRPKs constitutes a major way of regulating such ... -
Exposure of differentiated airway smooth muscle cells to serum stimulates both induction of hypoxia-inducible factor-1 alpha and airway responsiveness to ACh
Chachami, G.; Hatziefthimiou, A.; Liakos, P.; Ioannou, M. G.; Koukoulis, G. K.; Bonanou, S.; Molyvdas, P. A.; Simos, G.; Paraskeva, E. (2007)Airway smooth muscle (ASM) cells are characterized by phenotypic plasticity and can switch between differentiated and proliferative phenotypes. In rabbit tracheal ASM cells that had been differentiated in vitro by serum ... -
The flavonoid quercetin induces hypoxia-inducible factor-1 alpha (HIF-1 alpha) and inhibits cell proliferation by depleting intracellular iron
Triantafyllou, A.; Liakos, P.; Tsakalof, A.; Chachami, G.; Paraskeva, E.; Molyvdas, P. A.; Georgatsou, E.; Simos, G.; Bonanou, S. (2007)Quercetin, a flavonoid with anti- oxidant, metal chelating, kinase modulating and anti- proliferative properties, can induce hypoxia- inducible factor-1 alpha (HIF-1 alpha) in normoxia, but its mechanism of action has not ... -
Flavonoids induce HIF-1 alpha but impair its nuclear accumulation and activity
Triantafyllou, A.; Mylonis, L.; Simos, G.; Bonanou, S.; Tsakalof, A. (2008)Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is the regulatory subunit of the transcription factor HIF-1, which is highly involved in the pathology of diseases associated with tissue hypoxia. In this study we investigated ... -
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Mylonis, I.; Chachami, G.; Samiotaki, M.; Panayotou, G.; Paraskeva, E.; Kalousi, A.; Georgatsou, E.; Bonanou, S.; Simos, G. (2006)Hypoxia-inducible factor 1 (HIF-1) controls the expression of most genes induced by hypoxic conditions. Regulation of expression and activity of its inducible subunit, HIF-1α, involves several post-translational modifications. ... -
Identification of the commonest cystic fibrosis transmembrane regulator gene Delta F508 mutation: evaluation of PCR-single-strand conformational polymorphism and polyacrylamide gel electrophoresis
Kakavas, K. V.; Noulas, A. V.; Kanakis, I.; Bonanou, S.; Karamanos, N. K. (2006)In the present study we investigated whether single-strand conformational polymorphism (SSCP) and polyacrylamide gel electrophoresis (PAGE) could be used for the identification of the CFTR Delta F508 gene mutation, which ... -
Identification of the four most common beta-globin gene mutations in Greek beta-thalassemic patients and carriers by PCR-SSCP: Advantages and limitations of the method
Kakavas, K. V.; Noulas, A.; Chalkias, C.; Hadjichristodoulou, C.; Georgiou, L.; Georgatsou, E.; Bonanou, S. (2006)In the present study we investigated whether the single-strand conformational polymorphism (SSCP) method could be employed to identify (rather than simply detect) the four most common beta-globin gene mutations in the Greek ... -
Isolation of hypoxia-inducible factor 1 (HIF-1) inhibitors from frankincense using a molecularly imprinted polymer
Lakka, A.; Mylonis, I.; Bonanou, S.; Simos, G.; Tsakalof, A. (2011)Hypoxia-Inducible Factor 1 (HIF-1), a transcriptional activator, is highly involved in the pathology of cancer. Inhibition of HIF-1 retards tumor growth and enhances treatment efficiency when used in combination with chemo- ... -
MgcRacGAP interacts with HIF-1 alpha and regulates its transcriptional activity
Lyberopoulou, A.; Venieris, E.; Mylonis, I.; Chachami, G.; Pappas, I.; Simos, G.; Bonanou, S.; Georgatsou, E. (2007)HIF-1 alpha is the inducible subunit of the dimeric transcription factor HIF-1 (Hypoxia Inducible Factor 1). It is induced by hypoxia and hypoxia-mimetics in most cell types, as well as non-hypoxic signals such as growth ... -
Regulation of HIF-1alpha activity in airway smooth muscle cells: the role of cobalt and serum
Chachami, G.; Simos, G.; Bonanou, S.; Molyvdas, P. A.; Paraskeva, E. (2005)