Sfoglia per Autore "Asprodini, E. K."
Items 1-9 di 9
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Acute in vivo exposure to fentanyl reduces GABA immunoreactivity in the CA1 area of the rat hippocampus
Kouvaras, E.; Kilindris, T.; Vasilaki, A.; Asprodini, E. K. (2008)The effect of in vivo fentanyl treatment on GABAergic immunoreactivity was studied in the CA1 area of the rat hippocampus. Animals were treated either with saline or fentanyl (4x80 μg/kg, s.c./15min). GABA immunohistochemistry ... -
Caffeine metabolism in liver cirrhosis
Begas, E.; Asprodini, E. K.; Papakosta, S.; Maglaras, L.; Benakis, A.; Dalekos, G. (2005)Caffeine is metabolized primarily by CYP1A2. Several methods have been developed for the in vivo assessment of CYP1A2 activity using caffeine as a probe drug (2). These methods include the determination of caffeine clearance ... -
Determination of N-acetylation phenotyping in a Greek population using caffeine as a metabolic probe
Asprodini, E. K.; Zifa, E.; Papageorgiou, I.; Benakis, A. (1998)Studies of isoniazid, the well known antituberculosis drug, have revealed that N-acetylation polymorphism, is of great clinical importance. In humans, N-acetylation is one of the most important pathways in the inactivation ... -
Development and validation of a reversed-phase HPLC method for CYP1A2 phenotyping by use of a caffeine metabolite ratio in saliva
Begas, E.; Kouvaras, E.; Tsakalof, A. K.; Bounitsi, M.; Asprodini, E. K. (2015)CYP1A2 is important for metabolizing various clinically used drugs. Phenotyping of CYP1A2 may prove helpful for drug individualization therapy. Several HPLC methods have been developed for quantification of caffeine ... -
Endothelin-1 (ET1) modifies the in-vitro contractile response of human uterine myometrium to KCl
Domali, A.; Molyvdas, P. A.; Asprodini, E. K.; Messinis, I. E. (1999) -
Fentanyl treatment reduces GABAergic inhibition in the CA1 area of the hippocampus 24 h after acute exposure to the drug
Kouvaras, E.; Asprodini, E. K.; Asouchidou, I.; Vasilaki, A.; Kilindris, T.; Michaloudis, D.; Koukoutianou, I.; Papatheodoropoulos, C.; Kostopoulos, G. (2008)The effect of in vivo fentanyl treatment on synaptic transmission was studied in the CA1 area of the rat hippocampus. Animals were treated either with saline or fentanyl (4 x 80 mu g/kg, s.c./15 min). Intracellular in vitro ... -
In vivo evaluation of CUP1A2 and CYP2A6 activities in a Greek population during menopause
Begas, E.; Kouvaras, E.; Tsiokou, V.; Asprodini, E. K. (2008)Human CYP enzyme system is involved in the metabolism of various endogenous compounds. Previous studies have shown that CYP activity is influenced by age and gender. In the present study caffeine metabolites were used for ... -
In vivo evaluation of CYP1A2 CYP2A6, NAT-2 and xanthine oxidase activities in a Greek population sample by the RP-HPLC monitoring of caffeine metabolic ratios
Begas, E.; Kouvaras, E.; Tsakalof, A.; Papakosta, S.; Asprodini, E. K. (2007)A RP-HPLC method was developed for the assessment of caffeine and its metabolites in urine and was used for the evaluation of the CYP1A2, CYP2A6, xanthine oxidase (XO) and N-acetyl-transferase-2 (NAT-2) in vivo activities ... -
Prevention of postoperative adhesion formation by individual and combined administration of 4 per cent icodextrin and dimetindene maleate
Tepetes, K.; Asprodini, E. K.; Christodoulidis, G.; Spyridakis, M.; Kouvaras, E.; Hatzitheofilou, K. (2009)Background, To date, no single method has been successful in eliminating peritoneal adhesion formation after major abdominal surgery. This study evaluated the individual and possible synergistic effect of a local intraperitoneal ...