Parcourir par auteur "Pissas, G."
Voici les éléments 1-20 de 27
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CD8+T-cell auto-reactivity is dependent on the expression of the immunoproteasome subunit LMP7 in exposed to lipopolysaccharide antigen presenting cells and epithelial target cells
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2013)Proteasome generates peptides for presentation to CD8+ T-cells by antigen presenting cells (APCs) and peripheral cells. Inflammation alters proteasome to immunoproteasome, producing a different pool of peptides. The effect ... -
Damage-associated molecular patterns derived from mitochondria may contribute to the hemodialysis-associated inflammation
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2014)Inflammation is common in hemodialysis (HD) patients. Mitochondrial damage-associated molecular patterns (DAMPs) are released during cell necrosis or apoptosis and induce inflammation. Cell apoptosis is increased in HD ... -
Dichloroacetate at therapeutic concentration alters glucose metabolism and induces regulatory t-cell differentiation in alloreactive human lymphocytes
Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Antoniadis, N.; Liakopoulos, V.; Stefanidis, I. (2013)Background: Most cancer cells rely on aerobic glycolysis. Dichloroacetate (DCA) inhibits aerobic glycolysis and is a promising relatively nontoxic anticancer compound. However, rapidly proliferating effector T-cells also ... -
Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2014)Hepatitis B virus (HBV) is a major global health problem. Despite the success of the general measures against blood transmitted infections in hemodialysis (HD) units, the prevalence of HBV infection among the HD patients ... -
Ferroportin in monocytes of hemodialysis patients and its associations with hepcidin, inflammation, markers of iron status and resistance to erythropoietin
Eleftheriadis, T.; Pissas, G.; Remoundou, M.; Filippidis, G.; Antoniadi, G.; Oustampasidou, N.; Liakopoulos, V.; Stefanidis, I. (2014)Disturbed iron homeostasis contributes to resistance to recombinant human erythropoietin (rHuEpo) in hemodialysis (HD) patients. Increased hepcidin, which downregulates the iron exporter ferroportin, has been incriminated. ... -
Increased Plasma Angiogenin Level is Associated and May Contribute to Decreased T-Cell Zeta-Chain Expression in Hemodialysis Patients
Eleftheriadis, T.; Kartsios, C.; Pissas, G.; Liakopoulos, V.; Antoniadi, G.; Galaktidou, G.; Stefanidis, I. (2013)Hemodialysis (HD) patients are characterized by impaired T-cell function at least in part because of T-cell zeta-chain downregulation due to inflammation. Angiogenin responds as an acute phase reactant, is increased in HD ... -
Increased visfatin in hemodialysis patients is associated with decreased demands for recombinant human erythropoietin
Eleftheriadis, T.; Pissas, G.; Remoundou, M.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2013)Background: Studies detected an association between visfatin and markers of iron metabolism in patients with insulin resistance. In this study, such a relation was evaluated in hemodialysis (HD) patients. Also relations ... -
Indoleamine 2,3-dioxygenase depletes tryptophan, activates general control non-derepressible 2 kinase and down-regulates key enzymes involved in fatty acid synthesis in primary human CD4+ T cells
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2015)Indoleamine 2,3-dioxygenase (IDO) is expressed in antigen-presenting cells and exerts immunosuppressive effects on CD4+ T cells. One mechanism is through the inhibition of aerobic glycolysis. Another prerequisite for T-cell ... -
Indoleamine 2,3-dioxygenase increases p53 levels in alloreactive human T cells, and both indoleamine 2,3-dioxygenase and p53 suppress glucose uptake, glycolysis and proliferation
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Spanoulis, A.; Liakopoulos, V.; Stefanidis, I. (2014)Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity by inhibiting T-cell proliferation and altering glucose metabolism. The tumor suppressor p53 also alters these cellular processes with similar results. The ... -
The Indoleamine 2,3-dioxygenase Inhibitor 1-methyl-tryptophan Suppresses Mitochondrial Function, Induces Aerobic Glycolysis and Decreases Interleukin-10 Production in Human Lymphocytes
Eleftheriadis, T.; Pissas, G.; Karioti, A.; Antoniadi, G.; Liakopoulos, V.; Dafopoulou, K.; Pournaras, S.; Koukoulis, G.; Stefanidis, I. (2012)Background: Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity. It is known that IDO induces T-cell differentiation to regulatory T-cells (Treg) through tryptophan depletion and/or kynurenine pathway products. ... -
Inhibition of indoleamine 2,3-dioxygenase in mixed lymphocyte reaction affects glucose influx and enzymes involved in aerobic glycolysis and glutaminolysis in alloreactive T-cells
Eleftheriadis, T.; Pissas, G.; Yiannaki, E.; Markala, D.; Arampatzis, S.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2013)Indoleamine 2,3-dioxygenase (IDO) suppresses adaptive immunity. T-cell proliferation and differentiation to effector cells require increased glucose consumption, aerobic glycolysis and glutaminolysis. The effect of IDO on ... -
Inhibition of Indoleamine 2,3-Dioxygenase Not Only Blocks Autoreactive B Cell Activation, But It Also Reduces Production of Antibodies in General: Comment on the Article by Pigott and Mandik-Nayak
Eleftheriadis, T.; Pissas, G.; Liakopoulos, V.; Stefanidis, I. (2013) -
Late onset of clinically apparent central vein stenosis due to previous central venous catheter in a patient with inherited thrombophilia
Eleftheriadis, T.; Liakopoulos, V.; Antoniadi, G.; Pissas, G.; Leivaditis, K.; Stefanidis, I. (2014)We describe a case of a patient with a functional kidney transplant who was admitted to our department with clinically evident central vein stenosis (CVS) 7 years after the removal of a central venous catheter (CVC) from ... -
Malate dehydrogenase-2 inhibitor LW6 promotes metabolic adaptations and reduces proliferation and apoptosis in activated human T-cells
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Liakopoulos, V.; Stefanidis, I. (2015)Activated T cells rely on aerobic glycolysis and glutaminolysis in order to proliferate and differentiate into effector cells. Therefore, intervention in these metabolic pathways inhibits proliferation. The aim of the ... -
Perilipin-1 in Hemodialyzed Patients: Association With History of Coronary Heart Disease and Lipid Profile
Eleftheriadis, T.; Antoniadi, G.; Liakopoulos, V.; Pissas, G.; Arampatzis, S.; Sparopoulou, T.; Galaktidou, G.; Stefanidis, I. (2012)Perilipin-1 surrounds lipid droplets in both adipocytes and in atheroma plaque foam cells and controls access of lipases to the lipid core. In hemodialysis (HD) patients, dyslipidemia, malnutrition, inflammation and ... -
Plasma Angiogenin and Vascular Endothelial Growth Factor A Among Hemodialysis Patients
Eleftheriadis, T.; Antoniadi, G.; Liakopoulos, V.; Pissas, G.; Stefanidis, I.; Galaktidou, G. (2012)Introduction. Angiogenesis plays a role in the pathogenesis of coronary heart disease (CHD) and diabetes mellitus (DM) pathology, and certain angiogenic factors are increased by inflammation. The aim of this study was to ... -
Plasma Indoleamine 2,3-Dioxygenase and Arginase Type I May Contribute to Decreased Blood T-Cell Count in Hemodialysis Patients
Eleftheriadis, T.; Yiannaki, E.; Antoniadi, G.; Liakopoulos, V.; Pissas, G.; Galaktidou, G.; Stefanidis, I. (2012)Background: Acquired immunity is impaired in hemodialysis (HD) patients, and decreased T-cell number may contribute. Indoleamine 2,3-dioxygenase (IDO) and arginase type I (ARG) catabolize tryptophane and arginine, respectively, ... -
Plasma vascular endothelial growth factor and angiogenin are positively related to erythropoietin dose in hemodialysis patients
Eleftheriadis, T.; Antoniadi, G.; Liakopoulos, V.; Pissas, G.; Galaktidou, G.; Stefanidis, I. (2013)Purpose: Experimental data confirmed that erythropoietin (EPO) administration alters the course of various pathological situations such as heart failure and tumor growth by inducing vascular endothelial growth factor-A ... -
The Renal Endothelium in Diabetic Nephropathy
Eleftheriadis, T.; Antoniadi, G.; Pissas, G.; Liakopoulos, V.; Stefanidis, I. (2013)Diabetic nephropathy is the leading cause of end-stage renal disease. Diabetes mellitus is characterized by generalized endothelial dysfunction. However, recent data also emphasizes the role of local renal endothelium ... -
Serum copper and ferroportin in monocytes of hemodialysis patients are both decreased but unassociated
Eleftheriadis, T.; Pissas, G.; Antoniadi, G.; Filippidis, G.; Golfinopoulos, S.; Spanoulis, A.; Liakopoulos, V.; Stefanidis, I. (2014)Disturbed iron homeostasis contributes to resistance to recombinant human erythropoietin (rHuEpo) in hemodialysis (HD) patients. Although increased hepcidin, which downregulates the iron exporter ferroportin, had been ...