Listar por autor "Anastasakis, D."
Mostrando ítems 1-4 de 4
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Competitive Inhibition of Human Poly(A)-Specific Ribonuclease (PARN) by Synthetic Fluoro-Pyranosyl Nucleosides
Balatsos, N. A. A.; Vlachakis, D.; Maragozidis, P.; Manta, S.; Anastasakis, D.; Kyritsis, A.; Vlassi, M.; Komiotis, D.; Stathopoulos, C. (2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting deadenylase that mediates, together with other exonucleases, the eukaryotic mRNA turnover and thus is actively involved in the regulation of gene expression. ... -
Effect of natural nucleotides and their synthetic analogues on mRNA turnover by human poly(A)specific ribonuclease (PARN)
Balatsos, N.; Anastasakis, D.; Maragozidis, P.; Manta, S.; Komiotis, D.; Stathopoulos, C. (2008) -
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis
Balatsos, N. A. A.; Anastasakis, D.; Stathopoulos, C. (2009)Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the ... -
Modulation of Poly(A)-specific Ribonuclease (PARN): Current Knowledge and Perspectives
Balatsos, N. A. A.; Maragozidis, P.; Anastasakis, D.; Stathopoulos, C. (2012)Deadenylation is the exoribonucleolytic shortening of eukaryotic poly(A) tails. It is often the first and rate-limiting step for mRNA decay and translational silencing. The process is catalysed by a diversity of deadenylases, ...