Auflistung Nach Schlagwort "polymorphism"
Anzeige der Dokumente 21-40 von 47
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A Field Synopsis and Meta-Analysis of Genetic Association Studies in Peripheral Arterial Disease: The CUMAGAS-PAD Database
(2009)In an electronic search of the literature, the authors systematically retrieved all published studies that investigated genetic susceptibility to peripheral arterial disease (PAD). They created a comprehensive database of ... -
The Generalized Odds Ratio as a Measure of Genetic Risk Effect in the Analysis and Meta-Analysis of Association Studies
(2010)The significance of risk effects in genetic association studies is assessed using the odds ratio for various genetic models (dominant, recessive and co-dominant) by merging genotypes. These models are not independent and ... -
Genetic association studies in patients with traumatic brain injury
(2010)Traumatic brain injury (TBI) constitutes a major cause of mortality and disability worldwide, especially among young individuals. It is estimated that despite all the recent advances in the management of TBI, approximately ... -
Genetic basis of Parkinson disease
(2010)Over the past few years, considerable progress has been made in understanding the molecular mechanisms of Parkinson disease (PD). Mutations in certain genes are found to cause monogenic forms of the disorder, with autosomal ... -
Genetic factors influencing outcome from neurotrauma
(2012)Purpose of review Clinical outcome after neurotrauma is considerably variable and can only partly be explained by known prognostic factors. There is converging evidence from genetic research that a number of genetic variants ... -
Genetic polymorphisms in amyotrophic lateral sclerosis: Evidence for implication in detoxification pathways of environmental toxicants
(2018)Amyotrophic lateral sclerosis (ALS) is a severe neurodegenerative disease of the central nervous system, characterized by progressive loss of motor neurons, and occurring in both sporadic and familial form. The origin of ... -
Genetic variants of homocysteine/folate metabolism pathway and risk of inflammatory bowel disease: a synopsis and meta-analysis of genetic association studies
(2010)A synopsis and meta-analysis of studies that investigated the association between genetic variants involved in the homocysteine/folate metabolism pathway and risk of inflammatory bowel disease (IBD) were conducted. Four ... -
Genetic variation associated with ischemic heart failure: A HuGE review and meta-analysis
(2007)The ischemic etiology of heart failure is an independent prognostic factor associated with worse long-term outcome. Recent evidence indicates a role for genetic susceptibility to ischemic heart failure. The authors ... -
Inhibin alpha gene and susceptibility to premature ovarian failure: a data synthesis
(2009)Candidate-gene association studies that examined the association between polymorphisms of the inhibin alpha gene (G769A, C16T and A124G) and premature ovarian failure (POF) have reported contradictory results. Thus, a ... -
Is 472G/A catechol-O-methyl-transferase gene polymorphism related to panic disorder?
(2007)Objectives Case-control studies relating 472G/A catechol-O-methyl-transferase polymorphism with the risk of developing panic disorder showed inconclusive or contradictory results. To shed some light on these results a ... -
Is catechol-O-methyl transferase 472G/A gene polymorphism a marker associated with alcoholism?
(2011)Objectives The available published evidence from the genetic association studies on the association between alcoholism and catechol-O-methyl transferase 472G/A gene polymorphism have produced inconclusive results. To ... -
Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility
(2008)A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the ... -
MHC class II DRB1 and DQA2 gene polymorphisms in four indigenous breeds of sheep (Ovis aries)
(2016)Major histocompatibility complex (MHC) contains highly polymorphic genes, coding receptors that participate in the immune responses. Information of MHC polymorphism from domestic animals could be used in genetic improvement ... -
Paraoxonase 1 gene polymorphisms in patients with osteonecrosis of the femoral head with and without cerebral white matter lesions
(2007)Cerebral white matter lesions (WML) are present in more than 50% of patients with osteonecrosis of the femoral head (ONFH). Paraoxonase 1(PON1) gene product is a detoxifying and pesticide metabolizing enzyme. Genetic ... -
Polymorphisms and haplotypes in TLR9 and MYD88 are associated with the development of Hodgkin's lymphoma: a candidate-gene association study
(2009)Toll-like receptors (TLRs) and myeloid differentiation primary response protein 88 (MYD88) gene polymorphisms may be involved in the pathogenesis of Hodgkin's lymphoma (HL) through altered immunoregulatory and inflammatory ... -
Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer: a genetic association study and meta-analysis
(2010)The endothelial nitric oxide synthase gene (NOS3) has been proposed as a candidate gene for breast cancer (BC), however, the specific role of variants and haplotypes has not been clarified. We examined the association of ... -
RANTES promoter gene polymorphisms and susceptibility to severe respiratory syncytial virus-induced bronchiolitis
(2008)Background: Severe respiratory syncytial virus (RSV) infection is characterized by enhanced chemokine activity. Several studies have linked increased regulated on activation, normal T cell expressed and secreted (RANTES) ... -
Recurrent horizontal transfer identifies mitochondrial positive selection in a transmissible cancer
(2020)Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative ... -
The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis
(2005)The association between retincipathy in type 2 diabetes [diabetic retinopathy (DR)] and the C677T polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene has been investigated in several case-control studies. ... -
The role of G196A polymorphism in the brain-derived neurotrophic factor gene in the cause of Parkinson's disease: a meta-analysis
(2005)The association between Parkinson's disease (PD) and the G196A polymorphism in the brain-derived neurotrophic factor (BDNF) gene has been investigated in several case-control studies, producing contradictory results: one ...