Όλο το DSpace

Πλοήγηση ανά Θέμα "phenotype"

Αποτελέσματα 21-40 από 178

    • Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine 

      Nijs J., George S.Z., Clauw D.J., Fernández-de-las-Peñas C., Kosek E., Ickmans K., Fernández-Carnero J., Polli A., Kapreli E., Huysmans E., Cuesta-Vargas A.I., Mani R., Lundberg M., Leysen L., Rice D., Sterling M., Curatolo M. (2021)
      Chronic pain is a leading cause of disability globally and associated with enormous health-care costs. The discrepancy between the extent of tissue damage and the magnitude of pain, disability, and associated symptoms ...

    • Cerebral and non-cerebral coenurosis: on the genotypic and phenotypic diversity of Taenia multiceps 

      Christodoulopoulos G., Dinkel A., Romig T., Ebi D., Mackenstedt U., Loos-Frank B. (2016)
      We characterised the causative agents of cerebral and non-cerebral coenurosis in livestock by determining the mitochondrial genotypes and morphological phenotypes of 52 Taenia multiceps isolates from a wide geographical ...

    • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy revisited: Genotype-phenotype correlations of all published cases 

      Xiromerisiou G., Marogianni C., Dadouli K., Zompola C., Georgouli D., Provatas A., Theodorou A., Zervas P., Nikolaidou C., Stergiou S., Ntellas P., Sokratous M., Stathis P., Paraskevas G.P., Bonakis A., Voumvourakis K., Hadjichristodoulou C., Hadjigeorgiou G.M., Tsivgoulis G. (2020)
      Objective The aim of this study was to evaluate the correlation between the various NOTCH3 mutations and their clinical and genetic profile, along with the presentation of a novel mutation in a patient.MethodsHere, we ...

    • Characterizing Long COVID: Deep Phenotype of a Complex Condition 

      Deer R.R., Rock M.A., Vasilevsky N., Carmody L., Rando H., Anzalone A.J., Basson M.D., Bennett T.D., Bergquist T., Boudreau E.A., Bramante C.T., Byrd J.B., Callahan T.J., Chan L.E., Chu H., Chute C.G., Coleman B.D., Davis H.E., Gagnier J., Greene C.S., Hillegass W.B., Kavuluru R., Kimble W.D., Koraishy F.M., Köhler S., Liang C., Liu F., Liu H., Madhira V., Madlock-Brown C.R., Matentzoglu N., Mazzotti D.R., McMurry J.A., McNair D.S., Moffitt R.A., Monteith T.S., Parker A.M., Perry M.A., Pfaff E., Reese J.T., Saltz J., Schuff R.A., Solomonides A.E., Solway J., Spratt H., Stein G.S., Sule A.A., Topaloglu U., Vavougios G.D., Wang L., Haendel M.A., Robinson P.N. (2021)
      Background: Numerous publications describe the clinical manifestations of post-acute sequelae of SARS-CoV-2 (PASC or “long COVID”), but they are difficult to integrate because of heterogeneous methods and the lack of a ...

    • Cholesterol metabolism related genes in osteoarthritis 

      Papathanasiou I., Anastasopoulou L., Tsezou A. (2021)
      Cholesterol homeostasis plays a significant role in skeletal development and the dysregulation of cholesterol-related mechanism has been shown to be involved in the development of cartilage diseases including osteoarthritis ...

    • Chronic Heart Failure: Diagnosis and Management beyond LVEF Classification 

      Triposkiadis F., Starling R.C. (2022)
      [No abstract available]

    • Chronic l-menthol-induced browning of white adipose tissue hypothesis: A putative therapeutic regime for combating obesity and improving metabolic health 

      Sakellariou P., Valente A., Carrillo A.E., Metsios G.S., Nadolnik L., Jamurtas A.Z., Koutedakis Y., Boguszewski C., Andrade C.M.B., Svensson P.-A., Kawashita N.H., Flouris A.D. (2016)
      Introduction: Obesity constitutes a serious global health concern reaching pandemic prevalence rates. The existence of functional brown adipose tissue (BAT) in adult humans has provoked intense research interest in the ...

    • Clinical phenotype in patients with α-synuclein Parkinson's disease living in Greece in comparison with patients with sporadic Parkinson's disease 

      Papapetropoulos, S.; Paschalis, C.; Athanassiadou, A.; Papadimitriou, A.; Ellul, J.; Polymeropoulos, M. H.; Papapetropoulos, Th (2001)
      Objective - An Ala53Thr mutation of the α-synuclein gene has been recently identified as a rare cause of autosomal Parkinson's disease (PD). The clinical characteristics of 15 patients with PD living in Greece with the ...

    • Clinical profile of severe asthmatics receiving biological treatment: see behind the scenes 

      Kotsiou O.S., Gourgoulianis K.I., Daniil Z. (2021)
      The clinical phenotyping of severe asthma could improve treatment outcomes, quality of life, morbidity, and mortality of asthma patients. The growing availability of rich clinical data could provide opportunities to address ...

    • Complex distal 10q rearrangement in a girl with mild intellectual disability: Follow up of the patient and review of the literature of non-acrocentric satellited chromosomes 

      Sarri, C.; Douzgou, S.; Gyftodimou, Y.; Tümer, Z.; Ravn, K.; Pasparaki, A.; Sarafidou, T.; Kontos, H.; Kokotas, H.; Karadima, G.; Grigoriadou, M.; Pandelia, E.; Theodorou, V.; Moschonas, N. K.; Petersen, M. B. (2011)
      We report on an intellectually disabled girl with a de novo satellited chromosome 10 (10qs) and performed a review of the literature of the non-acrocentric satellited chromosomes (NASC). Satellites and stalks normally occur ...

    • The continuum of SARS-CoV-2's neurotropism and the potential for immune-mediated neuronal injury 

      Vavougios G.D. (2020)
      [No abstract available]

    • COVID-19 Phenotypes and Comorbidity: A Data-Driven, Pattern Recognition Approach Using National Representative Data from the United States 

      Vavougios G.D., Stavrou V.T., Konstantatos C., Sinigalias P.-C., Zarogiannis S.G., Kolomvatsos K., Stamoulis G., Gourgoulianis K.I. (2022)
      The aim of our study was to determine COVID-19 syndromic phenotypes in a data-driven manner using the survey results based on survey results from Carnegie Mellon University’s Delphi Group. Monthly survey results (>1 million ...

    • Crosstalk mechanisms between the WNT signaling pathway and long non-coding RNAs 

      Zarkou V., Galaras A., Giakountis A., Hatzis P. (2018)
      The WNT/β-catenin signaling pathway controls a plethora of biological processes throughout animal development and adult life. Because of its fundamental role during animal lifespan, the WNT pathway is subject to strict ...

    • Cross‐Sectional Survey of Antibiotic Resistance in Extended Spectrum β‐Lactamase‐Producing Enterobacteriaceae Isolated from Pigs in Greece 

      Tsekouras N., Athanasakopoulou Z., Diezel C., Kostoulas P., Braun S.D., Sofia M., Monecke S., Ehricht R., Chatzopoulos D.C., Gary D., Krähmer D., Spyrou V., Christodoulopoulos G., Billinis C., Papatsiros V.G. (2022)
      This study aimed to estimate the prevalence of extended‐spectrum β‐lactamase-producing (ESBL) bacteria in swine. Thus, 214 fecal samples were collected from suckling and weaned piglets from 34 farms in Greece (out of an ...

    • Deciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays 

      Tzartos J.S., Karagiorgou K., Tzanetakos D., Breza M., Evangelopoulos M.E., Pelidou S.-H., Bakirtzis C., Nikolaidis I., Koutsis G., Notas K., Chroni E., Markakis I., Grigoriadis N.C., Anagnostouli M., Orologas A., Parisis D., Karapanayiotides T., Papadimitriou D., Kostadima V., Elloul J., Xidakis I., Maris T., Zisimopoulou P., Tzartos S., Kilidireas C. (2020)
      IgG antibodies to myelin oligodendrocyte glycoprotein (MOG) detected by cell based assays (CBA) have been identified in a constantly expanding spectrum of CNS demyelinating disorders. However, a universally accepted CBA ...

    • Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations 

      Boer C.G., Hatzikotoulas K., Southam L., Stefánsdóttir L., Zhang Y., Coutinho de Almeida R., Wu T.T., Zheng J., Hartley A., Teder-Laving M., Skogholt A.H., Terao C., Zengini E., Alexiadis G., Barysenka A., Bjornsdottir G., Gabrielsen M.E., Gilly A., Ingvarsson T., Johnsen M.B., Jonsson H., Kloppenburg M., Luetge A., Lund S.H., Mägi R., Mangino M., Nelissen R.R.G.H.H., Shivakumar M., Steinberg J., Takuwa H., Thomas L.F., Tuerlings M., Loughlin J., Arden N., Birrell F., Carr A., Deloukas P., Doherty M., McCaskie A.W., Ollier W.E.R., Rai A., Ralston S.H., Spector T.D., Wallis G.A., Martinsen A.E., Willer C., Fors E.A., Mundal I., Hagen K., Nilsen K.B., Lie M.U., Børte S., Brumpton B., Nielsen J.B., Fritsche L.G., Zhou W., Heuch I., Storheim K., Tyrpenou E., Koukakis A., Chytas D., Evangelopoulos D.S., Efstathios C., Pneumaticos S., Nikolaou V.S., Malizos K., Anastasopoulou L., Abecasis G., Baras A., Cantor M., Coppola G., Deubler A., Economides A., Lotta L.A., Overton J.D., Reid J.G., Shuldiner A., Karalis K., Siminovitch K., Beechert C., Forsythe C., Fuller E.D., Gu Z., Lattari M., Lopez A., Schleicher T.D., Padilla M.S., Widom L., Wolf S.E., Pradhan M., Manoochehri K., Bai X., Balasubramanian S., Boutkov B., Eom G., Habegger L., Hawes A., Krasheninina O., Lanche R., Mansfield A.J., Maxwell E.K., Nafde M., O'Keeffe S., Orelus M., Panea R., Polanco T., Rasool A., Salerno W., Staples J.C., Li D., Sharma D., Banerjee I., Bovijn J., Locke A., Verweij N., Haas M., Hindy G., De T., Akbari P., Sosina O., Ferreira M.A.R., Jones M.B., Mighty J., LeBlanc M.G., Mitnaul L.J., Babis G.C., Cheung J.P.Y., Kang J.H., Kraft P., Lietman S.A., Samartzis D., Slagboom P.E., Stefansson K., Thorsteinsdottir U., Tobias J.H., Uitterlinden A.G., Winsvold B., Zwart J.-A., Davey Smith G., Sham P.C., Thorleifsson G., Gaunt T.R., Morris A.P., Valdes A.M., Tsezou A., Cheah K.S.E., Ikegawa S., Hveem K., Esko T., Wilkinson J.M., Meulenbelt I., Lee M.T.M., van Meurs J.B.J., Styrkársdóttir U., Zeggini E., arcOGEN Consortium, HUNT All-In Pain, ARGO Consortium, Regeneron Genetics Center (2021)
      Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ...

    • Detection of unusual mutation within the VP1 region of different re-isolates of poliovirus Sabin vaccine 

      Dedepsidis, E.; Karakasiliotis, I.; Paximadi, E.; Kyriakopoulou, Z.; Komiotis, D.; Markoulatos, P. (2006)
      In the present study, a genomic analysis of full VP1 sequence region of 15 clinical re-isolates (14 healthy vaccinees and one bone marrow tumor patient) was conducted, aiming to the identification of mutations and to the ...

    • The Developmental Program of Murine Erythroleukemia Cells 

      Tsiftoglou, A. S.; Pappas, I. S.; Vizirianakis, I. S. (2002)
      Hematopoietic stem cells (HSCs) or early progenitors respond to external stimuli in bone marrow and differentiate into cell-restricted lineages of blood cells of limited life span. In leukemias, however, early hematopoietic ...

    • Diagnostic and clinical significance of Crohn's disease-specific pancreatic anti-GP2 and anti-CUZD1 antibodies 

      Pavlidis P., Komorowski L., Teegen B., Liaskos C., Koutsoumpas A.L., Smyk D.S., Perricone C., Mytilinaiou M.G., Stocker W., Forbes A., Bogdanos D.P. (2016)
      Background: Pancreatic autoantibodies (PAB) targeting GP2 and CUZD1 are Crohn's disease (CrD)-markers. The clinical significance of anti-GP2 antibodies has been assessed, but that of anti-CUZD1 remains elusive. The aim of ...

    • Dietary effects of Sideritis scardica “mountain tea” on human in vivo activities of xenobiotic metabolizing enzymes in healthy subjects 

      Begas E., Kilindris T., Kouvaras E., Tsioutsioumi A., Kouretas D., Asprodini E.K. (2018)
      Sideritis scardica (S. scardica) is an endemic plant of the Balkan Peninsula traditionally used as herbal tea for inflammation and gastric disorders. Aqueous herbal extracts may affect the activity of Phase I and II enzymes ...