• Ceftazidime/avibactam in the era of carbapenemase-producing Klebsiella pneumoniae: Experience from a national registry study 

      Karaiskos I., ikaraiskos@hygeia.gr, Daikos G.L., Gkoufa A., Adamis G., Stefos A., Symbardi S., Chrysos G., Filiou E., Basoulis D., Mouloudi E., Galani L., Akinosoglou K., Arvaniti K., Masgala A., Petraki M., Papadimitriou E., Galani I., Poulakou G., Routsi C., Giamarellou H. (2021)
      Background: Infections caused by KPC-producing Klebsiella pneumoniae (Kp) are associated with high mortality. Therefore, new treatment options are urgently required. Objectives: To assess the outcomes and predictors of ...
    • Characterization of Patients with Embolic Strokes of Undetermined Source in the NAVIGATE ESUS Randomized Trial 

      Kasner S.E., Lavados P., Sharma M., Wang Y., Wang Y., Dávalos A., Shamalov N., Cunha L., Lindgren A., Mikulik R., Arauz A., Lang W., Czlonkowska A., Eckstein J., Gagliardi R., Amarenco P., Ameriso S.F., Tatlisumak T., Veltkamp R., Hankey G.J., Toni D.S., Bereczki D., Uchiyama S., Ntaios G., Yoon B.-W., Brouns R., DeVries Basson M.M., Endres M., Muir K., Bornstein N., Ozturk S., O'Donnell M., Mundl H., Pater C., Weitz J., Peacock W.F., Swaminathan B., Kirsch B., Berkowitz S.D., Peters G., Pare G., Themeles E., Shoamanesh A., Connolly S.J., Hart R.G., NAVIGATE ESUS Steering Committee and Investigators (2018)
      Background: The New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial vs. ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial is a randomized phase-III trial comparing ...
    • Circulating suPAR associates with severity and in-hospital progression of COVID-19 

      Chalkias A., Skoulakis A., Papagiannakis N., Laou E., Tourlakopoulos K., Pagonis A., Michou A., Ntalarizou N., Mermiri M., Ragias D., Bernal-Morell E., Cebreiros López I., García de Guadiana-Romualdo L., Eugen-Olsen J., Gourgoulianis K., Pantazopoulos I., Chalkias A., Skoulakis A., Laou E., Michou A., Ntalarizou N., Mermiri M., Ragias D., Tourlakopoulos K., Pagonis A., Gourgoulianis K., Pantazopoulos I., Papagiannakis N., Kampolis C., García de Guadiana-Romualdo L., Albaladejo-Otón M.D., Rodríguez Mulero M.D., Galindo Martínez M., Hernández Olivo M., Campos Rodríguez V., Cebreiros López I., Arnaldos Carrillo M., Noguera Velasco J.A., Pascual Figal D.A., Bernal-Morell E., Alcaraz García A., Alcaraz García M.J., Martínez Martínez M., Esteban-Torrella P., Sancho-Rodríguez N., Eugen-Olsen J., for the SPARCOL Investigators (2022)
      Background: COVID-19 disease progression is characterized by hyperinflammation and risk stratification may aid in early aggressive treatment and advanced planning. The aim of this study was to assess whether suPAR and other ...
    • Clinical and laboratory features of children with community-acquired pneumonia are associated with distinct radiographic presentations 

      Falup-Pecurariu O.G., Diez-Domingo J., Esposito S., Finn A., Rodrigues F., Spoulou V., Syrogiannopoulos G.A., Usonis V., Greenberg D., on behalf of CAP-PRI (2018)
      Chest radiographs from children with community-acquired pneumonia (CAP) were categorized into three distinct presentations and each presentation was correlated to clinical and laboratory findings. Children < 59 months ...
    • Clinical and virological heterogeneity of hepatitis delta in different regions world-wide: The Hepatitis Delta International Network (HDIN) 

      Wranke A., Pinheiro Borzacov L.M., Parana R., Lobato C., Hamid S., Ceausu E., Dalekos G.N., Rizzetto M., Turcanu A., Niro G.A., Lubna F., Abbas M., Ingiliz P., Buti M., Ferenci P., Vanwolleghem T., Hayden T., Dashdorj N., Motoc A., Cornberg M., Abbas Z., Yurdaydin C., Manns M.P., Wedemeyer H., Hardtke S., Serrano B., Wöbse M., Heidrich B., Muche M., Gatselis N., Zachou K., Ho E., Smedile A., Fontana R., Gish R., Obretin D., Stern R., the Hepatitis Delta International Network (2018)
      Background & Aims: Chronic hepatitis D (delta) is a major global health burden. Clinical and virological characteristics of patients with hepatitis D virus (HDV) infection and treatment approaches in different regions ...
    • Clinical features and outcomes of patients with tubercular uveitis treated with antitubercular therapy in the collaborative ocular tuberculosis study (COTS)-1 

      Agrawal R., Gunasekeran D.V., Grant R., Agarwal A., Kon O.M., Nguyen Q.D., Pavesio C., Gupta V., Gupta B., Aggarwal K., Murthy S.L., Westcott M., Phaik C.S., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Carreño E., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Singh R., Sharma A., Sharma K., Zierhut M., Raje D., Cunningham E., Kempen J., Collaborative Ocular Tuberculosis Study (COTS)-1 Study Group (2017)
      IMPORTANCE Eradication of systemic tuberculosis (TB) has been limited by neglected populations and the HIV pandemic. Whereas ocular TB often presents as uveitis without any prior evidence of systemic TB, the existing ...
    • The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends 

      Agarwal A., Agrawal R., Gunasekaran D.V., Raje D., Gupta B., Aggarwal K., Murthy S.L., Westcott M., Chee S.P., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Carreño E., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Cunningham E., Nguyen Q.D., Pavesio C., Gupta V. (2019)
      Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study ...
    • The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 165 Patients with Tubercular Anterior Uveitis 

      Agrawal R., MD FCRS, Betzler B., MBBS, Testi I., MD, Mahajan S., MBBS, Agarwal A., MS, Gunasekeran D.V., MD, Raje D., PhD, Aggarwal K., MS, Murthy S.I., DNB, Westcott M., FRCSOphth, Chee S.-P., FRCSEd, Mccluskey P., MD, Ho S.L., FRCSGlasg, Teoh S., FRCSEd, Cimino L., MD, Biswas J., MS, Narain S., MD, Agarwal M., MS, Mahendradas P., DNB, Khairallah M., MD, Jones N., FRCSOphth, Tugal-Tutkun I., MD, Babu K., DNB, Basu S., MS, Carreño E., MD, Lee R., PhD, Al-Dhibi H., MD, Bodaghi B., MD, Invernizzi A., MD, Goldstein D.A., MD, Herbort C.P., MD, Barisani-Asenbauer T., PhD, González-López J.J., PhD, Androudi S., MD, Bansal R., MS, Moharana B., MS, Esposti S., MD, Tasiopoulou A., MD, Nadarajah S., MD, Agarwal M., DNB, Abraham S., MD, Vala R., MD, Singh R., MS, Sharma A., MD, Sharma K., PhD, Zierhut M., PhD, Kon O.M., MRCP, Cunningham E.T., PhD, Kempen J.H., PhD, Nguyen Q.D., PhD, Pavesio C., FRCSOphth, Gupta V., MS (2020)
      Purpose: The Collaborative Ocular Tuberculosis Study (COTS) Group sought to address the diagnostic uncertainty through retrospective cohort analysis of treatment regimens and therapeutic outcomes for patients with tubercular ...
    • Combined pulmonary fibrosis and emphysema characteristics in a Greek cohort 

      Malli F., Papakosta D., Antoniou K., Dimadi M., Polychronopoulos V., Malagari K., Oikonomou A., Bouros D.E., Daniil Z. (2019)
      Background: Combined pulmonary fibrosis and emphysema (CPFE) has recently received great attention, with studies suggesting that it presents a distinct clinical entity while others have challenged this hypothesis. This ...
    • Comparable or higher prevalence of comorbidities in antiphospholipid syndrome vs rheumatoid arthritis: A multicenter, case-control study 

      Panopoulos S., Thomas K., Georgiopoulos G., Boumpas D., Katsiari C., Bertsias G., Drosos A.A., Boki K., Dimitroulas T., Garyfallos A., Papagoras C., Katsimbri P., Tziortziotis A., Adamichou C., Kaltsonoudis E., Argyriou E., Vosvotekas G., Sfikakis P.P., Vassilopoulos D., Tektonidou M.G. (2021)
      Objectives: Evidence on comorbidity prevalence in antiphospholipid syndrome (APS) and its difference from high comorbidity burden rheumatic diseases is limited. Herein, we compare multiple comorbidities between APS and RA. ...
    • Complementary feeding and overweight in european preschoolers: The toybox-study 

      Usheva N., Galcheva S., Cardon G., De Craemer M., Androutsos O., Kotowska A., Socha P., Koletzko B.V., Moreno L.A., Iotova V., Manios Y., the ToyBox-study Group (2021)
      Complementary feeding (CF) should start between 4–6 months of age to ensure infants’ growth but is also linked to childhood obesity. This study aimed to investigate the association of the timing of CF, breastfeeding and ...
    • Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial 

      Krishnan K., Scutt P., Woodhouse L., Adami A., Becker J.L., Cala L.A., Casado A.M., Chen C., Dineen R.A., Gommans J., Koumellis P., Christensen H., Collins R., Czlonkowska A., Lees K.R., Ntaios G., Ozturk S., Phillips S.J., Sprigg N., Szatmari S., Wardlaw J.M., Bath P.M., ENOS Investigators (2016)
      Background and purpose More than 50% of patients with acute intracerebral hemorrhage (ICH) are taking antihypertensive drugs before ictus. Although antihypertensive therapy should be given long term for secondary prevention, ...
    • Corifollitropin alfa compared with follitropin beta in GnRH-antagonist ovarian stimulation protocols in an unselected population undergoing IVF/ICSI 

      Siristatidis C., Dafopoulos K., Christoforidis N., Anifandis G., Pergialiotis V., Papantoniou N. (2017)
      Recombinant DNA technologies have produced Corifollitropin alfa (CFa) used during IVF/ICSI in order to keep the circulating FSH levels above the threshold necessary to support multi-follicular growth for a week. In this ...
    • Covid-19 home confinement negatively impacts social participation and life satisfaction: A worldwide multicenter study 

      Ammar A., Chtourou H., Boukhris O., Trabelsi K., Masmoudi L., Brach M., Bouaziz B., Bentlage E., How D., Ahmed M., Mueller P., Mueller N., Hsouna H., Aloui A., Hammouda O., Paineiras-Domingos L.L., Braakman-Jansen A., Wrede C., Bastoni S., Pernambuco C.S., Mataruna L., Taheri M., Irandoust K., Khacharem A., Bragazzi N.L., Strahler J., Adrian J., Andreeva A., Khoshnami S.C., Samara E., Zisi V., Sankar P., Ahmed W.N., Romdhani M., Delhey J., Bailey S.J., Bott N.T., Gargouri F., Chaari L., Batatia H., Ali G.M., Abdelkarim O., Jarraya M., Abed K.E., Souissi N., Van Gemert-Pijnen L., Riemann B.L., Riemann L., Moalla W., Gómez-Raja J., Epstein M., Sanderman R., Schulz S., Jerg A., Al-Horani R., Mansi T., Jmail M., Barbosa F., Santos F., Šimunič B., Pišot R., Pišot S., Gaggioli A., Zmijewski P., Apfelbacher C., Steinacker J., Saad H.B., Glenn J.M., Chamari K., Driss T., Hoekelmann A., ECLB-COVID19 Consortium (2020)
      Public health recommendations and governmental measures during the new coronavirus disease (COVID-19) pandemic have enforced numerous restrictions on daily living including social distancing, isolation, and home confinement. ...
    • COVID-19 Infection among Elite Football Players: A Nationwide Prospective Cohort Study 

      Papagiannis D., Laios T., Tryposkiadis K., Kouriotis K., Roussis X., Basdekis G., Boudouris P., Cholevas C., Karakitsios S., Kakavas P., Kiriakidis T., Kouloumentas P., Kouvidis G., Manoudis G., Nikolaou P., Theos C., Piskopakis A.-N., Rallis I., Ristanis S., Toliopoulos A., Zisis G., Theodorakis Y., Gourgoulianis K.I., Rachiotis G. (2022)
      Little is known about the risk of COVID-19 infection among footballers. We aimed to investigate the incidence and characteristics of COVID-19 infection among footballers. In total, 480 football players of Super League ...
    • Daptomycin for the treatment of osteomyelitis and orthopaedic device infections: real-world clinical experience from a European registry 

      Malizos K., Sarma J., Seaton R.A., Militz M., Menichetti F., Riccio G., Gaudias J., Trostmann U., Pathan R., Hamed K. (2016)
      Osteomyelitis is a serious infection predominantly caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Orthopaedic device-related infections are complex and require a careful ...
    • Determinants of cognitive performance and decline in 20 diverse ethno-regional groups: A COSMIC collaboration cohort study 

      Lipnicki D.M., Makkar S.R., Crawford J.D., Thalamuthu A., Kochan N.A., Lima-Costa M.F., Castro-Costa E., Ferri C.P., Brayne C., Stephan B., Llibre-Rodriguez J.J., Llibre-Guerra J.J., Valhuerdi-Cepero A.J., Lipton R.B., Katz M.J., Derby C.A., Ritchie K., Ancelin M.-L., Carrière I., Scarmeas N., Yannakoulia M., Hadjigeorgiou G.M., Lam L., Chan W.-C., Fung A., Guaita A., Vaccaro R., Davin A., Kim K.W., Han J.W., Suh S.W., Riedel-Heller S.G., Roehr S., Pabst A., van Boxtel M., Köhler S., Deckers K., Ganguli M., Jacobsen E.P., Hughes T.F., Anstey K.J., Cherbuin N., Haan M.N., Aiello A.E., Dang K., Kumagai S., Chen T., Narazaki K., Ng T.P., Gao Q., Nyunt M.S.Z., Scazufca M., Brodaty H., Numbers K., Trollor J.N., Meguro K., Yamaguchi S., Ishii H., Lobo A., Lopez-Anton R., Santabárbara J., Leung Y., Lo J.W., Popovic G., Sachdev P.S., Cohort Studies of Memory in an International Consortium (COSMIC) (2019)
      Background: With no effective treatments for cognitive decline or dementia, improving the evidence base for modifiable risk factors is a research priority. This study investigated associations between risk factors and ...
    • Developing patients' experiences database after hospital discharge: Another step in improving stroke care 

      Konstantakopoulou O., Galanis P., Kaitelidou D., Karagkouni I., Korompoki E., Ntaios G., Vemmos K., Papastefanatos S., Papastefanatos G., Tsampalas E., Alexopoulou H., Kalliontzakis I., Kouridaki A., Tountopoulou A., Kouzi I., Milionis H., Evaggelou C., Karagkiozi E., Hatzitolios A.I., Savopoulos C., Myrou A., Mavraganis G., Vemmou A., Siskou O. (2020)
      The aim of this study was to assess stroke patients' experiences in regards to hospital stay and during discharge. A cross-sectional study with retrospective data collection was conducted including patients (n=135) with ...
    • Development and Testing of a Novel Anaesthesia Induction/Ventilation Protocol for Patients With Cardiogenic Shock Complicating Acute Myocardial Infarction 

      Chalkias A., Pavlopoulos F., Papageorgiou E., Tountas C., Anania A., Panteli M., Beloukas A., Xanthos T. (2018)
      Background: Cardiogenic shock is a life-threatening condition and patients might require rapid sequence induction (RSI) and mechanical ventilation. In this study, we evaluated a new RSI/mechanical ventilation protocol in ...
    • Direct oral anticoagulant-vs Vitamin K antagonist-related nontraumatic intracerebral hemorrhage 

      Tsivgoulis G., Lioutas V.-A., Varelas P., Katsanos A.H., Goyal N., Mikulik R., Barlinn K., Krogias C., Sharma V.K., Vadikolias K., Dardiotis E., Karapanayiotides T., Pappa A., Zompola C., Triantafyllou S., Kargiotis O., Ioakeimidis M., Giannopoulos S., Kerro A., Tsantes A., Mehta C., Jones M., Schroeder C., Norton C., Bonakis A., Chang J., Alexandrov A.W., Mitsias P., Alexandrov A.V. (2017)
      Objective: To compare the neuroimaging profile and clinical outcomes among patients with intracerebral hemorrhage (ICH) related to use of vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) for nonvalvular ...