Πλοήγηση ανά Θέμα "hypoxia inducible factor 1alpha"
Αποτελέσματα 21-33 από 33
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Myeloid-derived suppressor cells: Major figures that shape the immunosuppressive and angiogenic network in cancer
(2019)Myeloid-derived suppressor cells (MDSCs) constitute a vast population of immature myeloid cells implicated in various conditions. Most notably, their role in cancer is of great complexity. They exert immunosuppressive ... -
On the increased event rate of urinary tract infection and pneumonia in CKD patients treated with roxadustat for anemia
(2021)[No abstract available] -
Proteasome or immunoproteasome inhibitors cause apoptosis in human renal tubular epithelial cells under normoxic and hypoxic conditions
(2016)Purpose: Ischemic acute kidney injury is characterized by apoptosis of tubular epithelial cells. Proteasome plays a key role in cellular processes such as proliferation, apoptosis and inflammation. The results of animal ... -
Protein phosphatase PPP3CA (calcineurin A) down-regulates hypoxia-inducible factor transcriptional activity
(2019)Hypoxia-inducible factors (HIF) are master regulators of the response to hypoxia. Although several kinases are known to modify their oxygen sensitive HIF-α subunits or affect indirectly their function, little is known about ... -
Regulation of microRNA in systemic lupus erythematosus: The role of miR-21 and miR-210
(2020)miRNAs are small non-coding RNA molecules that participate through silencing in post-transcriptional regulation of gene expression. Recent studies have highlighted the importance of microRNAs (miRNAs) as regulators of both ... -
Reoxygenation induces reactive oxygen species production and ferroptosis in renal tubular epithelial cells by activating aryl hydrocarbon receptor
(2021)During the reperfusion phase of ischemia‑reper‑ fusion injury, reactive oxygen species (ROS) production aggravates the course of many diseases, including acute kidney injury. Among the various enzymes implicated in ROS ... -
The role of hypoxia-inducible factor-2 alpha in angiogenesis
(2018)Angiogenesis is a key enabling feature of mammalian embryonic development and tumor progression, which provides oxygen and nutrients that are required for vessel growth and tumor cell growth, respectively. Hypoxia is a ... -
The role of tissue oxygen tension in dengue virus replication
(2018)Low oxygen tension exerts a profound effect on the replication of several DNA and RNA viruses. In vitro propagation of Dengue virus (DENV) has been conventionally studied under atmospheric oxygen levels despite that in ... -
Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling
(2022)The cellular response to hypoxia, in addition to HIF-dependent transcriptional reprogramming, also involves less characterized transcription-independent processes, such as alternative splicing of the VEGFA transcript leading ... -
Specific inhibition of hif activity: Can peptides lead the way?
(2021)Reduced oxygen availability (hypoxia) is a characteristic of many disorders including cancer. Central components of the systemic and cellular response to hypoxia are the Hypoxia Inducible Factors (HIFs), a small family of ... -
Targeting neuroendocrine prostate cancer: Molecular and clinical perspectives
(2015)Neuroendocrine prostate carcinoma, either co-present with the local adenocarcinoma disease or as a result of transdifferentiation later in time, was described as one major process of emerging resistance to androgen deprivation ... -
Validated analysis of HIF-1α expression in cancer cells using a controlled and comparative immunoassay
(2010)The immunoreactivity of hypoxia inducible factor 1 α (HIF-1α) has been considered a reliable indicator of the HIF-1 pathway activation in tissue hypoxia. However, HIF-1α immunoreactivity has been evaluated with different ... -
Vitamin D and Hypoxia: Points of Interplay in Cancer
(2022)Vitamin D is a hormone that, through its action, elicits a broad spectrum of physiological responses ranging from classic to nonclassical actions such as bone morphogenesis and immune function. In parallel, many studies ...