• The Medical Research Council chronic dyspnea score predicts the survival of patients with idiopathic pulmonary fibrosis 

      Manali, E. D.; Stathopoulos, G. T.; Kollintza, A.; Kalomenidis, I.; Emili, J. M.; Sotiropoulou, C.; Daniil, Z.; Roussos, C.; Papiris, S. A. (2008)
      Background: The Medical Research Council (MRC) chronic dyspnea scale (6-point) is used in different clinical conditions to grade breathlessness on daily activities. We have previously shown that in patients with histologically ...
    • A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease 

      Daoussis D., Melissaropoulos K., Sakellaropoulos G., Antonopoulos I., Markatseli T.E., Simopoulou T., Georgiou P., Andonopoulos A.P., Drosos A.A., Sakkas L., Liossis S.-N. (2017)
      Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in SSc compared to standard treatment. ...
    • Non-Metastatic Pelvic Ewing's Sarcoma: Oncologic outcomes and evaluation of prognostic factors 

      Dramis A., Grimer R.J., Malizos K., Tillman R.M., Jeys L., Carter S.R. (2016)
      We are reporting our experience on patients with pelvic Ewing's Sarcoma treated in our unit. We retrospectively reviewed a series of patients with non-metastatic pelvic Ewing's sarcoma treated between 1977 and 2009. Patients ...
    • Octogenarians Are the New Sexagenarians: Cruciate-Retaining Total Knee Arthroplasty Is Not Inferior to Posterior-Stabilized Arthroplasty in Octogenarian Patients 

      D’ambrosi R., Menon P.H., Salunke A., Mariani I., Palminteri G., Basile G., Ursino N., Mangiavini L., Hantes M. (2022)
      Purpose: The primary goal of this study was to compare survivorship and functional results in individuals aged 80 and over who underwent total knee arthroplasty (TKA) with cruciate-retaining (CR) or posterior-stabilized ...
    • Overestimation of the risk of revision with Kaplan-Meier presenting the long-term outcome of total hip replacement in older patients 

      Lampropoulou-Adamidou K., Karachalios T.S., Hartofilakidis G. (2018)
      Introduction: The purpose of the present study was (i) to review the long-term outcome of cemented Charnley total hip replacements (THRs) performed by 1 surgeon (GH), 20 to 42 years ago, in patients ≥60 years, using both ...
    • Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis 

      Weismüller T.J., Strassburg C.P., Trivedi P.J., Hirschfield G.M., Trivedi P.J., Bergquist A., Said K., Imam M., Lazaridis K.N., Juran B.D., Cheung A., Lindor K.D., Weismüller T.J., Lenzen H., Manns M.P., Ponsioen C.Y., Beuers U., Holm K., Naess S., Karlsen T.H., Schrumpf E., Boberg K.M., Gotthardt D., Rupp C., Färkkilä M.A., Jokelainen K., Marschall H.-U., Benito de Valle M., Thorburn D., Saffioti F., Weersma R.K., Fevery J., Mueller T., Chazouillères O., Schulze K., Schramm C., Almer S., Pereira S.P., Levy C., Mason A., Bowlus C.L., Floreani A., Halilbasic E., Trauner M., Yimam K.K., Milkiewicz P., Milkiewicz P., Huynh D.K., Pares A., Manser C.N., Dalekos G.N., Eksteen B., Invernizzi P., Berg C.P., Kirchner G.I., Sarrazin C., Zimmer V., Fabris L., Braun F., Marzioni M., Schramm C., Chapman R.W., Chapman R.W., Lindor K.D., Imam M., Lindor K.D., Naess S., Karlsen T.H., Schrumpf E., Boberg K.M., Hansen B.E., Hansen B.E., Hansen B.E., on behalf of the, International PSC Study Group (2017)
      Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical ...
    • Poly(A)-specific ribonuclease and Nocturnin in squamous cell lung cancer: Prognostic value and impact on gene expression 

      Maragozidis P., Papanastasi E., Scutelnic D., Totomi A., Kokkori I., Zarogiannis S.G., Kerenidi T., Gourgoulianis K.I., Balatsos N.A.A. (2015)
      Background: Lung cancer is the leading cause of cancer mortality worldwide, mainly due to late diagnosis, poor prognosis and tumor heterogeneity. Thus, the need for biomarkers that will aid classification, treatment and ...
    • The prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5-azacytidine: Results from the Hellenic 5-azacytidine registry 

      Diamantopoulos P., Koumbi D., Kotsianidis I., Pappa V., Symeonidis A., Galanopoulos A., Zikos P., Papadaki H.A., Panayiotidis P., Dimou M., Hatzimichael E., Vassilopoulos G., Delimpasis S., Mparmparousi D., Papageorgiou S., Variami E., Kyrtsonis M.-C., Megalakaki A., Kotsopoulou M., Repousis P., Adamopoulos I., Kontopidou F., Christoulas D., Kourakli A., Tsokanas D., Konstantinos Papoutselis M., Kyriakakis G., Viniou N.-A., the Hellenic MDS study group (2019)
      In patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate ...
    • Recurrent Ischemic Stroke and Bleeding in Patients With Atrial Fibrillation Who Suffered an Acute Stroke While on Treatment With Nonvitamin K Antagonist Oral Anticoagulants: The RENO-EXTEND Study 

      Paciaroni M., Caso V., Agnelli G., Mosconi M.G., Giustozzi M., Seiffge D.J., Engelter S.T., Lyrer P., Polymeris A.A., Kriemler L., Zietz A., Putaala J., Strbian D., Tomppo L., Michel P., Strambo D., Salerno A., Remillard S., Buehrer M., Bavaud O., Vanacker P., Zuurbier S., Yperzeele L., Loos C.M.J., Cappellari M., Emiliani A., Zedde M., Abdul-Rahim A., Dawson J., Cronshaw R., Schirinzi E., Del Sette M., Stretz C., Kala N., Reznik M., Schomer A., Grory B.M., Jayaraman M., Mctaggart R., Yaghi S., Furie K.L., Masotti L., Grifoni E., Toni D., Risitano A., Falcou A., Petraglia L., Lotti E.M., Padroni M., Pavolucci L., Lochner P., Silvestrelli G., Ciccone A., Alberti A., Venti M., Traballi L., Urbini C., Kargiotis O., Rocco A., Diomedi M., Marcheselli S., Caliandro P., Zauli A., Reale G., Antonenko K., Rota E., Tassinari T., Saia V., Palmerini F., Aridon P., Arnao V., Monaco S., Cottone S., Baldi A., D'Amore C., Ageno W., Pegoraro S., Ntaios G., Sagris D., Giannopoulos S., Kosmidou M., Ntais E., Romoli M., Pantoni L., Rosa S., Bertora P., Chiti A., Canavero I., Saggese C.E., Plocco M., Giorli E., Palaiodimou L., Bakola E., Tsivgoulis G., Bandini F., Gasparro A., Terruso V., Mannino M., Pezzini A., Ornello R., Sacco S., Popovic N., Scoditti U., Genovese A., Denti L., Flomin Y., Mancuso M., Ferrari E., Caselli M.C., Ulivi L., Giannini N., De Marchis G.M. (2022)
      BACKGROUND: In patients with atrial fibrillation who suffered an ischemic stroke while on treatment with nonvitamin K antagonist oral anticoagulants, rates and determinants of recurrent ischemic events and major bleedings ...
    • Renal function and risk stratification of patients with embolic stroke of undetermined source 

      Ntaios G., Lip G.Y.H., Lambrou D., Michel P., Perlepe K., Eskandari A., Nannoni S., Sirimarco G., Strambo D., Vemmos K., Koroboki E., Manios E., Vemmou A., Rodríguez-Campello A., Cuadrado-Godia E., Roquer J., Arnao V., Caso V., Paciaroni M., Diez-Tejedor E., Fuentes B., Pardo J.R., Arauz A., Ameriso S.F., Pertierra L., Gómez-Schneider M., Hawkes M.A., Bandini F., Cano B.C., Mohedano A.M.I., Pastor A.G., Gil-Núñez A., Putaala J., Tatlisumak T., Barboza M.A., Karagkiozi E., Makaritsis K., Papavasileiou V. (2018)
      Background and Purpose-We aimed to assess if renal function can aid in risk stratification for ischemic stroke or transient ischemic attack (TIA) recurrence and death in patients with embolic stroke of undetermined source ...
    • Rivaroxaban for stroke prevention after embolic stroke of undetermined source 

      Hart R.G., Sharma M., Mundl H., Kasner S.E., Bangdiwala S.I., Berkowitz S.D., Swaminathan B., Lavados P., Wang Y., Wang Y., Davalos A., Shamalov N., Mikulik R., Cunha L., Lindgren A., Arauz A., Lang W., Czlonkowska A., Eckstein J., Gagliardi R.J., Amarenco P., Ameriso S.F., Tatlisumak T., Veltkamp R., Hankey G.J., Toni D., Bereczki D., Uchiyama S., Ntaios G., Yoon B.-W., Brouns R., Endres M., Muir K.W., Bornstein N., Ozturk S., O'Donnell M.J., De Vries Basson M.M., Pare G., Pater C., Kirsch B., Sheridan P., Peters G., Weitz J.I., Peacock W.F., Shoamanesh A., Benavente O.R., Joyner C., Themeles E., Connolly S.J., for the NAVIGATE ESUS Investigators (2018)
      BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a ...
    • Single-center experience with remote endarterectomy for the treatment of long-segment superficial femoral artery occlusion: Long-term results 

      Karathanos C., Spanos K., Saleptsis V., Antoniou G.A., Koutsias S., Giannoukas A.D. (2015)
      Objectives: Remote endarterectomy (RE) is a relatively minimally invasive procedure as an alternative to femoropopliteal above-knee bypass for the treatment of long-segment superficial femoral artery (SFA) occlusion. The ...
    • Statin treatment and outcomes after embolic stroke of undetermined source 

      Sagris D., Perlepe K., Leventis I., Samara S., Manios E., Korompoki E., Makaritsis K., Milionis H., Vemmos K., Ntaios G. (2021)
      The association of low-density lipoprotein cholesterol lowering with outcomes in embolic stroke of undetermined source (ESUS) patients is unclear. In these patients we aimed to assess the effect of statin on stroke recurrence, ...
    • Survivorship of monoblock trabecular metal cups in primary THA: Midterm results 

      Malizos, K. N.; Bargiotas, K.; Papatheodorou, L.; Hantes, M.; Karachalios, T. (2008)
      Monoblock trabecular metal cups are made of a novel porous material intended to enhance ingrowth and improve fixation. We prospectively followed 223 consecutive patients with 245 trabecular metal acetabular cups implanted ...
    • Syndecan-1, epithelial-mesenchymal transition markers (E-cadherin/β-catenin) and neoangiogenesis-related proteins (PCAM-1 and Endoglin) in colorectal cancer 

      Mitselou A., Galani V., Skoufi U., Arvanitis D.L., Lampri E., Ioachim E. (2016)
      The Syndecan-1 protein plays a crucial role in cell proliferation, cell adhesion, cell migration and angiogenesis and, at the same time, its co-expression with E-cadherin is regulated during epithelial-mesenchymal transition ...
    • TP53 mutations and protein immunopositivity may predict for poor outcome but also for trastuzumab benefit in patients with early breast cancer treated in the adjuvant setting 

      Fountzilas G., Giannoulatou E., Alexopoulou Z., Zagouri F., Timotheadou E., Papadopoulou K., Lakis S., Bobos M., Poulios C., Sotiropoulou M., Lyberopoulou A., Gogas H., Pentheroudakis G., Pectasides D., Koutras A., Christodoulou C., Papandreou C., Samantas E., Papakostas P., Kosmidis P., Bafaloukos D., Karanikiotis C., Dimopoulos M.-A., Kotoula V. (2016)
      Background: We investigated the impact of PIK3CA and TP53 mutations and p53 protein status on the outcome of patients who had been treated with adjuvant anthracycline-taxane chemotherapy within clinical trials in the pre- ...