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Πλοήγηση ανά Θέμα "B lymphocyte"

Αποτελέσματα 21-38 από 38

    • A multicenter, open-label, comparative study of B-cell depletion therapy with Rituximab for systemic sclerosis-associated interstitial lung disease 

      Daoussis D., Melissaropoulos K., Sakellaropoulos G., Antonopoulos I., Markatseli T.E., Simopoulou T., Georgiou P., Andonopoulos A.P., Drosos A.A., Sakkas L., Liossis S.-N. (2017)
      Objectives Rituximab (RTX) may favorably affect lung function and skin fibrosis in patients with systemic sclerosis (SSc). We aimed to assess long-term efficacy and safety of RTX in SSc compared to standard treatment. ...

    • Myeloid-derived suppressor cells in prostate cancer: Present knowledge and future perspectives 

      Koinis F., Xagara A., Chantzara E., Leontopoulou V., Aidarinis C., Kotsakis A. (2022)
      Several lines of research are being investigated to better understand mechanisms implicated in response or resistance to immune checkpoint blockade in prostate cancer (PCa). Myeloid-derived suppressor cells (MDSCs) have ...

    • Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa 

      Papoutsopoulou S., Tang J., Elramli A.H., Williams J.M., Gupta N., Ikuomola F.I., Sheibani-Tezerji R., Alam M.T., Hernández-Fernaud J.R., Caamaño J.H., Probert C.S., Muller W., Duckworth C.A., Mark Pritchard D. (2022)
      The alternative (noncanonical) nuclear factor-κB (NF-κB) signaling pathway predominantly regulates the function of the p52/RelB heterodimer. Germline Nfkb2 deficiency in mice leads to loss of p100/p52 protein and offers ...

    • Pathogenetic Aspects of Systemic Sclerosis: A View Through the Prism of B Cells 

      Melissaropoulos K., Iliopoulos G., Sakkas L.I., Daoussis D. (2022)
      Systemic sclerosis (SSc) is a rare fibrotic rheumatic disease, associated with psychological distress and increased morbidity and mortality due to skin involvement and internal organ damage. The current understanding of ...

    • Platelets in Systemic Sclerosis: the Missing Link Connecting Vasculopathy, Autoimmunity, and Fibrosis? 

      Ntelis K., Bogdanos D., Dimitroulas T., Sakkas L., Daoussis D. (2019)
      Purpose of Review: Platelets are no longer recognized solely as cell fragments regulating hemostasis. They have pleiotropic functions and they are linked directly or indirectly with the three cornerstones of systemic ...

    • The role of B cells in the pathogenesis of systemic sclerosis 

      Sakkas L.I., Bogdanos D.P. (2016)
      Systemic sclerosis (SSc) is characterized by extensive collagen deposition, microvasculopathy and autoantibodies. All three features can be promoted by activation of T cells and B cells. T cells are of Th2 type producing ...

    • The role of Dickkopf-1 in joint remodeling and fibrosis: A link connecting spondyloarthropathies and scleroderma? 

      Klavdianou K., Liossis S.-N., Sakkas L., Daoussis D. (2017)
      Background Dickkopf-1 (Dkk-1) is a soluble inhibitor of the canonical Wnt pathway, which plays critical roles in embryonic development. Evidence suggests that this molecule regulates several aspects of both bone biology ...

    • The role of invariant NKT in autoimmune liver disease: Can Vitamin D Act as an Immunomodulator? 

      Smyk D.S., Mavropoulos A., Mieli-Vergani G., Vergani D., Lenzi M., Bogdanos D.P. (2018)
      Natural killer T (NKT) cells are a distinct lineage of T cells which express both the T cell receptor (TCR) and natural killer (NK) cell markers. Invariant NKT (iNKT) cells bear an invariant TCR and recognize a small variety ...

    • The role of platelets in autoimmunity, vasculopathy, and fibrosis: Implications for systemic sclerosis 

      Ntelis K., Solomou E.E., Sakkas L., Liossis S.-N., Daoussis D. (2017)
      Introduction Systemic sclerosis (SSc) is an autoimmune disease characterized by vasculopathy, autoimmunity, and widespread dermal and visceral fibrosis. This article summarizes the current knowledge about the potential ...

    • Sarcoptes scabiei dermatitis in adult sheep: an immunohistochemical study of 34 chronic cases with extensive lesions 

      DOUKAS D., LIAKOU Z., TONTIS D. (2021)
      Ovine sarcoptic mange is a contagious ectoparasitic skin disease, seen in many countries with sheep production. Although several studies concerning dermatopathology have been published, the local cutaneous immune response ...

    • Spotlight on tocilizumab and its potential in the treatment of systemic sclerosis 

      Sakkas L.I. (2016)
      Systemic sclerosis (SSc) is a multisystem disease characterized by extensive collagen deposition in skin and internal organs, fibrointimal microvasculopathy, and activation of the immune system. T cells and B cells can ...

    • Systemic sclerosis: From pathogenesis towards targeted immunotherapies 

      Sakkas, L. I.; Chikanza, I. C.; Platsoucas, C. D. (2012)
      Systemic sclerosis (SSc), a chronic disease with widespread collagen deposition, has three pathogenetic facets: immune activation, microvasculopathy and fibroblast activation. Immune activation and microvasculopathy occur ...

    • Systemic sclerosis: New evidence re-enforces the role of B cells 

      Sakkas L.I., Bogdanos D.P. (2016)
      Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ...

    • A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis 

      Madireddy L., Patsopoulos N.A., Cotsapas C., Bos S.D., Beecham A., McCauley J., Kim K., Jia X., Santaniello A., Caillier S.J., Andlauer T.F.M., Barcellos L.F., Berge T., Bernardinelli L., Martinelli-Boneschi F., Booth D.R., Briggs F., Celius E.G., Comabella M., Comi G., Cree B.A.C., D’Alfonso S., Dedham K., Duquette P., Efthimios D., Esposito F., Fontaine B., Gasperi C., Goris A., Dubois B., Gourraud P.-A., Hadjigeorgiou G., Haines J., Hawkins C., Hemmer B., Hintzen R., Horakova D., Isobe N., Kalra S., Kira J.-I., Khalil M., Kockum I., Lill C.M., Lincoln M.R., Luessi F., Martin R., Oturai A., Palotie A., Pericak-Vance M.A., Henry R., Saarela J., Ivinson A., Olsson T., Taylor B.V., Stewart G.J., Harbo H.F., Compston A., Hauser S.L., Hafler D.A., Zipp F., De Jager P., Sawcer S., Oksenberg J.R., Baranzini S.E., International Multiple Sclerosis Genetics Consortium (2019)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...

    • T-cells and B-cells in systemic sclerosis 

      Sakkas, L. I.; Platsoucas, C. D. (2010)
      Systemic sclerosis (SSc) is characterized by activation of fibroblasts with extensive deposition of collagen, by small vessel vasculopathy with fibrointimal proliferation, and activation of the immune system, with hyper-γ- ...

    • Taci mutations in primary antibody deficiencies: A nationwide study in greece 

      Kakkas I., Tsinti G., Kalala F., Farmaki E., Kourakli A., Kapousouzi A., Dimou M., Kalaitzidou V., Sevdali E., Peristeri A.-M., Tsiouma G., Patiou P., Papadimitriou E., Vassilakopoulos T.P., Panayiotidis P., Kioumi A., Symeonidis A., Speletas M. (2021)
      Background and objectives: Monoallelic (heterozygous) or biallelic (homozygous or com-pound heterozygous) TACI mutations have been reported as the most common genetic defects in patients with common variable immunodeficiency ...

    • TNFRSF13C/BAFFR P21R and H159Y polymorphisms in multiple sclerosis 

      Ntellas P., Dardiotis E., Sevdali E., Siokas V., Aloizou A.-M., Tsinti G., Germenis A.E., Hadjigeorgiou G.M., Eibel H., Speletas M. (2020)
      Recent studies implicate B cells in multiple sclerosis (MS) pathogenesis, and consequently, several molecules participating in B cell survival and proliferation, including B-cell activating factor (BAFF), have recently ...

    • Urate crystals trigger B-cell receptor signal transduction and induce B-cell proliferation 

      Eleftheriadis T., Pissas G., Antoniadi G., Filippidis G., Liakopoulos V., Stefanidis I. (2020)
      Urate in its crystal form is a known danger-associated molecular pattern, which after its internalization activates cells of the innate immune system. However, by inducing lipid raft sequestration and clustering of ...