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Πλοήγηση ανά Συγγραφέα "Xiromerisiou, G."

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    • How genetics research in Parkinson's disease is enhancing understanding of the common idiopathic forms of the disease 

      Cookson, M. R.; Xiromerisiou, G.; Singleton, A. (2005)
      Purpose of review Rapid progress in genetics has meant that there are now five genes identified for 'Parkinson's disease'. The detailed phenotypes vary, but generally the dominant genes cause a Lewy body disease spectrum ...

    • The human prion gene M129V polymorphism is not associated with idiopathic Parkinson's disease in three distinct populations 

      Scholz, S. W.; Xiromerisiou, G.; Fung, H. C.; Eerola, J.; Hellstrom, O.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Tienari, P. J.; Fernandez, H. H.; Mandel, R.; Okun, M. S.; Gwinn-Hardy, K.; Singleton, A. B. (2006)
      Coexistence of prion disease and idiopathic Parkinson's disease (TPD) has been previously described. It remains unclear whether this relationship may reflect the high incidence of IPD or whether both prion and IPD share ...

    • IL-1RN and IL-1B gene polymorphisms and cerebral hemorrhagic events after traumatic brain injury 

      Hadjigeorgiou, G. M.; Paterakis, K.; Dardiotis, E.; Dardioti, M.; Aggelakis, K.; Tasiou, A.; Xiromerisiou, G.; Komnos, A.; Zintzaras, E.; Scarmeas, N.; Papadimitriou, A.; Karantanas, A. (2005)
      Objective: To investigate the association of (variable number tandem repeat) interleukin (IL) 1RN and (-511) IL-1B gene polymorphisms with brain hemorrhagic events after traumatic brain injury (TBI). Methods: Data from ...

    • Independent and joint effects of the MAPT and SNCA genes in Parkinson disease 

      Elbaz, A.; Ross, O. A.; Ioannidis, J. P. A.; Soto-Ortolaza, A. I.; Moisan, F.; Aasly, J.; Annesi, G.; Bozi, M.; Brighina, L.; Chartier-Harlin, M. C.; Destée, A.; Ferrarese, C.; Ferraris, A.; Gibson, J. M.; Gispert, S.; Hadjigeorgiou, G. M.; Jasinska-Myga, B.; Klein, C.; Krüger, R.; Lambert, J. C.; Lohmann, K.; Van De Loo, S.; Loriot, M. A.; Lynch, T.; Mellick, G. D.; Mutez, E.; Nilsson, C.; Opala, G.; Puschmann, A.; Quattrone, A.; Sharma, M.; Silburn, P. A.; Stefanis, L.; Uitti, R. J.; Valente, E. M.; Vilariño-Güell, C.; Wirdefeldt, K.; Wszolek, Z. K.; Xiromerisiou, G.; Maraganore, D. M.; Farrer, M. J. (2011)
      Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual ...

    • Interleukin 1a (-889) gene polymorphism and primary intracerebral hemorrhage 

      Dardiotis, E.; Dardioti, M.; Komnos, A.; Paterakis, K.; Tasiou, A.; Aggelakis, K.; Xiromerisiou, G.; Gabranis, J.; Papadimitriou, A.; Hadjigeorgiou, G. M. (2007)

    • Interleukin 2 (+114) gene polymorphism and traumatic brain injury 

      Dardioti, M.; Dardiotis, E.; Aggelakis, K.; Paterakis, K.; Komnos, A.; Karantanas, A.; Tasiou, A.; Xiromerisiou, G.; Hadjigeorgiou, G. (2006)

    • Interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms in Greek multiple sclerosis (MS) patients with bout-onset MS 

      Aggelakis, K.; Zacharaki, F.; Dardiotis, E.; Xiromerisiou, G.; Tsimourtou, V.; Ralli, S.; Gkaraveli, M.; Bourpoulas, D.; Rodopoulou, P.; Papadimitriou, A.; Hadjigeorgiou, G. (2010)
      We investigated the association of specific polymorphisms of the interleukin IL-1b (AvaI -511 and TaqI +3,953) and IL-1 receptor antagonist (IL-1RN) (a variable number of tandem repeats; VNTR) genes with both the susceptibility ...

    • The interplay between environmental and genetic factors in Parkinson's disease susceptibility: The evidence for pesticides 

      Dardiotis, E.; Xiromerisiou, G.; Hadjichristodoulou, C.; Tsatsakis, A. M.; Wilks, M. F.; Hadjigeorgiou, G. M. (2013)
      Parkinson's disease (PD) is a common neurodegenerative disorder characterized by dopaminergic neuron loss in the substantia nigra. Several genetic and environmental factors have been implicated in the pathogenesis of PD. ...

    • Lack of Association of the UCHL-1 Gene with Parkinson's Disease in a Greek Cohort: A Haplotype-Tagging Approach 

      Xiromerisiou, G.; Kyratzi, E.; Dardiotis, E.; Bozi, M.; Tsimourtou, V.; Stamboulis, E.; Ralli, S.; Vassilatis, D.; Gourbali, V.; Kountra, P. M.; Fountas, K.; Papadimitriou, A.; Stefanis, L.; Hadjigeorgiou, G. M. (2011)

    • Lack of evidence for a genetic association between FGF20 and Parkinson's disease in Finnish and Greek patients 

      Clarimon, J.; Xiromerisiou, G.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Dardiotis, E.; Peuralinna, T.; Papadimitriou, A.; Hadjigeorgiou, G. M.; Tienari, P. J.; Singleton, A. B. (2005)
      Background: Fibroblast growth factor 20 (FGF20) is a neurotrophic factor preferentially expressed in the substantia nigra of rat brain and could be involved in dopaminergic neurons survival. Recently, a strong genetic ...

    • A large-scale genetic association study to evaluate the contribution of Omi/HtrA2 (PARK13) to Parkinson's disease 

      Krüger, R.; Sharma, M.; Riess, O.; Gasser, T.; Van Broeckhoven, C.; Theuns, J.; Aasly, J.; Annesi, G.; Bentivoglio, A. R.; Brice, A.; Djarmati, A.; Elbaz, A.; Farrer, M.; Ferrarese, C.; Gibson, J. M.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Klein, C.; Lambert, J. C.; Lesage, S.; Lin, J. J.; Lynch, T.; Mellick, G. D.; de Nigris, F.; Opala, G.; Prigione, A.; Quattrone, A.; Ross, O. A.; Satake, W.; Silburn, P. A.; Tan, E. K.; Toda, T.; Tomiyama, H.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Maraganore, D. M. (2011)
      High-profile studies have provided conflicting results regarding the involvement of the Omi/HtrA2 gene in Parkinson's disease (PD) susceptibility. Therefore, we performed a large-scale analysis of the association of common ...

    • Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease 

      Nalls, M. A.; Pankratz, N.; Lill, C. M.; Do, C. B.; Hernandez, D. G.; Saad, M.; DeStefano, A. L.; Kara, E.; Bras, J.; Sharma, M.; Schulte, C.; Keller, M. F.; Arepalli, S.; Letson, C.; Edsall, C.; Stefansson, H.; Liu, X.; Pliner, H.; Lee, J. H.; Cheng, R.; Ikram, M. A.; Ioannidis, J. P. A.; Hadjigeorgiou, G. M.; Bis, J. C.; Martinez, M.; Perlmutter, J. S.; Goate, A.; Marder, K.; Fiske, B.; Sutherland, M.; Xiromerisiou, G.; Myers, R. H.; Clark, L. N.; Stefansson, K.; Hardy, J. A.; Heutink, P.; Chen, H.; Wood, N. W.; Houlden, H.; Payami, H.; Brice, A.; Scott, W. K.; Gasser, T.; Bertram, L.; Eriksson, N.; Foroud, T.; Singleton, A. B.; Ipdg; Parkins, G. Parkinson's Study Grp PSG; AndMe; GenePd; Ngrc; Hihg; Ashkenazi Jewish Dataset, Investiga; Charge; Nabec; Ukbec; Greek Parkinson's Dis, Consortium; Alzheimer Genetic Analysis, Gr (2014)
      We conducted a meta-analysis of Parkinson's disease genome-wide association studies using a common set of 7,893,274 variants across 13,708 cases and 95,282 controls. Twenty-six loci were identified as having genome-wide ...

    • Large-scale replication and heterogeneity in Parkinson disease genetic loci 

      Sharma, M.; Ioannidis, J. P. A.; Aasly, J. O.; Annesi, G.; Brice, A.; Van Broeckhoven, C.; Bertram, L.; Bozi, M.; Crosiers, D.; Clarke, C.; Facheris, M.; Farrer, M.; Garraux, G.; Gispert, S.; Auburger, G.; Vilariño-Güell, C.; Hadjigeorgiou, G. M.; Hicks, A. A.; Hattori, N.; Jeon, B.; Lesage, S.; Lill, C. M.; Lin, J. J.; Lynch, T.; Lichtner, P.; Lang, A. E.; Mok, V.; Jasinska-Myga, B.; Mellick, G. D.; Morrison, K. E.; Opala, G.; Pramstaller, P. P.; Pichler, I.; Park, S. S.; Quattrone, A.; Rogaeva, E.; Ross, O. A.; Stefanis, L.; Stockton, J. D.; Satake, W.; Silburn, P. A.; Theuns, J.; Tan, E. K.; Toda, T.; Tomiyama, H.; Uitti, R. J.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Yueh, K. C.; Zhao, Y.; Gasser, T.; Maraganore, D.; Krüger, R. (2012)
      Objective: Eleven genetic loci have reached genome-wide significance in a recent meta-analysis of genome-wide association studies in Parkinson disease (PD) based on populations of Caucasian descent. The extent to which ...

    • Low RLS prevalence and awareness in central Greece: an epidemiological survey 

      Hadjigeorgiou, G. M.; Stefanidis, I.; Dardiotis, E.; Aggellakis, K.; Sakkas, G. K.; Xiromerisiou, G.; Konitsiotis, S.; Paterakis, K.; Poultsidi, A.; Tsimourtou, V.; Ralli, S.; Gourgoulianis, K.; Zintzaras, E. (2007)
      Restless legs syndrome (RLS) is a sensorimotor disorder with a general population prevalence of 3-10%. A single, previous epidemiological study performed in southeast Europe reported the lowest prevalence rate amongst ...

    • A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants 

      Sharma, M.; Ioannidis, J. P. A.; Aasly, J. O.; Annesi, G.; Brice, A.; Bertram, L.; Bozi, M.; Barcikowska, M.; Crosiers, D.; Clarke, C. E.; Facheris, M. F.; Farrer, M.; Garraux, G.; Gispert, S.; Auburger, G.; Vilarino-Guell, C.; Hadjigeorgiou, G. M.; Hicks, A. A.; Hattori, N.; Jeon, B. S.; Jamrozik, Z.; Krygowska-Wajs, A.; Lesage, S.; Lill, C. M.; Lin, J. J.; Lynch, T.; Lichtner, P.; Lang, A. E.; Libioulle, C.; Murata, M.; Mok, V.; Jasinska-Myga, B.; Mellick, G. D.; Morrison, K. E.; Meitnger, T.; Zimprich, A.; Opala, G.; Pramstaller, P. P.; Pichler, I.; Park, S. S.; Quattrone, A.; Rogaeva, E.; Ross, O. A.; Stefanis, L.; Stockton, J. D.; Satake, W.; Silburn, P. A.; Strom, T. M.; Theuns, J.; Tan, E. K.; Toda, T.; Tomiyama, H.; Uitti, R. J.; Van Broeckhoven, C.; Wirdefeldt, K.; Wszolek, Z.; Xiromerisiou, G.; Yomono, H. S.; Yueh, K. C.; Zhao, Y.; Gasser, T.; Maraganore, D.; Kruger, R.; Consortium, Geopd (2012)
      Background Two recent studies identified a mutation (p.Asp620Asn) in the vacuolar protein sorting 35 gene as a cause for an autosomal dominant form of Parkinson disease. Although additional missense variants were described, ...

    • Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease 

      Li, Y.; Rowland, C.; Xiromerisiou, G.; Lagier, R. J.; Schrodi, S. J.; Dradiotis, E.; Ross, D.; Bui, N.; Catanese, J.; Aggelakis, K.; Grupe, A.; Hadjigeorgiou, G. (2008)
      Susceptibility to sporadic Parkinson's diseases (PD) is thought to be influence by both genetic and environmental factors and thier interaction with each other. Statistical models including multiples variants in axon ...

    • Paraoxonase 1 (PON1) gene polymorphisins (M55L and Q192R) and osteonecrosis of the femoral head with and without cerebral white matter lesions 

      Hadjigeorgiou, G. M.; Dardioti, M.; Dardiotis, E.; Aggelakis, K.; Xiromerisiou, G.; Tsimourtou, V.; Noulas, G.; Malizos, K.; Zimbis, A.; Papadimitriou, A.; Karantanas, A. (2005)

    • The protective effect of LRRK2 p.R1398H on risk of Parkinson's disease is independent of MAPT and SNCA variants 

      Heckman, M. G.; Elbaz, A.; Soto-Ortolaza, A. I.; Serie, D. J.; Aasly, J. O.; Annesi, G.; Auburger, G.; Bacon, J. A.; Boczarska-Jedynak, M.; Bozi, M.; Brighina, L.; Chartier-Harlin, M. C.; Dardiotis, E.; Destée, A.; Ferrarese, C.; Ferraris, A.; Fiske, B.; Gispert, S.; Hadjigeorgiou, G. M.; Hattori, N.; Ioannidis, J. P. A.; Jasinska-Myga, B.; Jeon, B. S.; Kim, Y. J.; Klein, C.; Kruger, R.; Kyratzi, E.; Lin, C. H.; Lohmann, K.; Loriot, M. A.; Lynch, T.; Mellick, G. D.; Mutez, E.; Opala, G.; Park, S. S.; Petrucci, S.; Quattrone, A.; Sharma, M.; Silburn, P. A.; Sohn, Y. H.; Stefanis, L.; Tadic, V.; Tomiyama, H.; Uitti, R. J.; Valente, E. M.; Vassilatis, D. K.; Vilariño-Güell, C.; White, L. R.; Wirdefeldt, K.; Wszolek, Z. K.; Wu, R. M.; Xiromerisiou, G.; Maraganore, D. M.; Farrer, M. J.; Ross, O. A. (2014)
      The best validated susceptibility variants for Parkinson's disease are located in the α-synuclein (SNCA) and microtubule-associated protein tau (MAPT) genes. Recently, a protective p.N551K-R1398H-K1423K haplotype in the ...

    • Screening for SNCA and LRRK2 mutations in Greek sporadic and autosomal dominant Parkinson's disease: identification of two novel LRRK2 variants 

      Xiromerisiou, G.; Hadjigeorgiou, G. M.; Gourbali, V.; Johnson, J.; Papakonstantinou, I.; Papadimitriou, A.; Singleton, A. B. (2007)
      Mutations in SNCA and LRRK2 genes, encoding alpha-synuclein and leucine-rich repeat kinase 2, respectively, cause autosomal dominant Parkinson's disease (AdPD). The LRRK2 G2019S (c.6055G > A) and R1441G (c.4321C > G) ...

    • Testing association between LRRK2 and Parkinson's disease and investigating linkage disequilibrium 

      Paisan-Ruiz, C.; Evans, E. W.; Jain, S.; Xiromerisiou, G.; Gibbs, J. R.; Eerola, J.; Gourbali, V.; Hellstrom, O.; Duckworth, J.; Papadimitriou, A.; Tienari, P. J.; Hadjigeorgiou, G. M.; Singleton, A. B. (2006)
      Background: We and others recently identified the gene underlying PARK8 linked Parkinson's disease (PD). This gene, LRRK2, contains mutations that cause an autosomal dominant PD, including a mutation, G2019S, which is the ...