Parcourir par auteur "Kyriakopoulou, Z."
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Molecular epidemiology and evolutionary dynamics of Echovirus 3 serotype
Kyriakopoulou, Z.; Bletsa, M.; Tsakogiannis, D.; Dimitriou, T. G.; Amoutzias, G. D.; Gartzonika, C.; Levidiotou-Stefanou, S.; Markoulatos, P. (2015)Echovirus 3 (E3) serotype has been related with several neurologic diseases, although it constitutes one of the rarely isolated serotypes, with no report of epidemics in Europe. The aim of the present study was to provide ... -
Molecular identification and full genome analysis of an echovirus 7 strain isolated from the environment in Greece
Kyriakopoulou, Z.; Dedepsidis, E.; Pliaka, V.; Mastorakos, P.; Stamati, A.; Pratti, A.; Levidiotou-Stefanou, S.; Markoulatos, P. (2010)Two enteroviruses from river water and four from sewage treatment plant were isolated in Larissa, Greece, that all shared the same sequence. A full genome analysis was conducted in an attempt to reveal the evolutionary ... -
Multiplex PCR assay for the rapid identification of human papillomavirus genotypes 16, 18, 45, 35, 66, 33, 51, 58, and 31 in clinical samples
Tsakogiannis, D.; Diamantidou, V.; Toska, E.; Kyriakopoulou, Z.; Dimitriou, T. G.; Ruether, I. G.; Gortsilas, P.; Markoulatos, P. (2015)The causal association between persistent human papillomavirus (HPV) infection and cervical cancer has lead to the development of a variety of molecular assays for HPV detection. The present study focused on the development ... -
A new RT-PCR assay for the identification of the predominant recombination types in 2C and 3D genomic regions of vaccine-derived poliovirus strains
Pliaka, V.; Dedepsidis, E.; Kyriakopoulou, Z.; Mpirli, K.; Tsakogiannis, D.; Pratti, A.; Levidiotou-Stefanou, S.; Markoulatos, P. (2010)In the post-eradication era of wild polioviruses, the only remaining sources of poliovirus infection worldwide would be the vaccine-derived polioviruses (VDPVs). As the preponderance of countries certified to be polio-free ... -
Nucleotide polymorphisms of the human papillomavirus 16 E1 gene
Tsakogiannis, D.; Darmis, F.; Gortsilas, P.; Ruether, I. G. A.; Kyriakopoulou, Z.; Dimitriou, T. G.; Amoutzias, G.; Markoulatos, P. (2014)The E1 ORF is one of the most conserved regions in the human papillomavirus (HPV) genome. The complete E1 gene of the HPV16 genome was amplified with four overlapping primer sets in 16 high-grade (CIN II, III) and 13 ... -
Partial 3D gene sequences of Coxsackie viruses reveal interspecies exchanges
Bolanaki, E.; Kottaridi, C.; Markoulatos, P.; Kyriakopoulou, Z.; Margaritis, L.; Katsorchis, T. (2007)The 3D region of 46 clinical Coxsackievirus strains, primarily belonging to the human enterovirus B species (HEV-B), were analyzed using nucleotide distance matrices and phylogeny software. The conclusions from previously ... -
PCR assays for the identification of rare recombination types from VP1 to 3D genomic region of vaccine derived poliovirus strains
Dimitriou, T. G.; Pliaka, V.; Kyriakopoulou, Z.; Ruether, I. G. A.; Tsakogiannis, D.; Fountoucidou, P.; Gartzonika, C.; Levidiotou-Stefanou, S.; Markoulatos, P. (2014)Poliomyelitis has been effectively controlled by the use of inactivated poliovirus vaccine (IPV) or trivalent live attenuated oral poliovirus vaccine (OPV). Since 1964, the use of OPV in mass vaccinations has resulted in ... -
Possible recombination and gene adaptation exchanges among clinical echovirus strains: crossing the temporal and topological barriers
Kottaridi, C.; Bolanaki, E.; Kyriakopoulou, Z.; Dedepsidis, E.; Pratti, A.; Markoulatos, P. (2007)Six echovirus strains belonging to serotypes echovirus 6, 13, and 30 were investigated in the present work by sequencing of the whole 2C gene and about 560 nt of the 5' part of 3-dimensional genomic region. Four of the 6 ... -
Prevalence of HPV16 E1-1374 boolean AND 63nt variants in Greek women
Tsakogiannis, D.; Kyriakopoulou, Z.; Darmis, F.; Ruether, I. G. A.; Dimitriou, T. G.; Orfanoudakis, G.; Panotopoulou, E.; Markoulatos, P. (2014)Recent studies have focused on sequence variation of the HPV16 E1 gene. The present study investigates the prevalence of E1-1374<^>63nt duplication in the Greek population, and the sequence variation at the 5 ' end of the ... -
Recombination among human non-polio enteroviruses: implications for epidemiology and evolution
Kyriakopoulou, Z.; Pliaka, V.; Amoutzias, G. D.; Markoulatos, P. (2015)Human enteroviruses (EV) belong to the Picornaviridae family and are among the most common viruses infecting humans. They consist of up to 100 immunologically and genetically distinct types: polioviruses, coxsackieviruses ... -
Retrospective characterization of a vaccine-derived poliovirus type 1 isolate from sewage in greece
Dedepsidis, E.; Kyriakopoulou, Z.; Pliaka, V.; Kottaridi, C.; Bolanaki, E.; Levidiotou-Stefanou, S.; Komiotis, D.; Markoulatos, P. (2007)Retrospective molecular and phenotypic characterization of a vaccine-derived poliovirus (VDPV) type 1 isolate (7/b/97) isolated from sewage in Athens, Greece, in 1997 is reported. VP1 sequencing of this isolate revealed ... -
Retrospective molecular and phenotypic analysis of poliovirus vaccine strains isolated in Greece
Pliaka, V.; Filliponi, M. E.; Kyriakopoulou, Z.; Ruether, I. G. A.; Tsakogiannis, D.; Gartzonika, C.; Levidiotou-Stefanou, S.; Markoulatos, P. (2011)The live oral poliovirus vaccine (OPV) strains are genetically unstable, causing, in rare cases, vaccine-associated paralytic poliomyelitis. Reversions of the known attenuating mutations in OPV strains and intertypic ... -
Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis
Pliaka, V.; Kyriakopoulou, Z.; Markoulatos, P. (2012)The Global Polio Eradication Initiative was launched in 1988 with the aim to eliminate paralytic poliomyelitis. Two effective vaccines are available: inactivated polio vaccine (IPV) and oral polio vaccine (OPV). Since 1964, ... -
Sequence variation analysis of the E2 gene of human papilloma virus type 16 in cervical lesions from women in Greece
Tsakogiannis, D.; Ruether, I. G. A.; Kyriakopoulou, Z.; Pliaka, V.; Theoharopoulou, A.; Skordas, V.; Panotopoulou, E.; Nepka, C.; Markoulatos, P. (2012)The E2 gene of human papilloma virus is expressed at the early stage of the viral life cycle, encoding the E2 transcription factor, and regulates the expression of E6 and E7 oncogenes. Disruption of E2 gene due to viral ... -
A seroprevalence study of poliovirus antibody against a collection of recombinant and non-recombinant poliovirus vaccine strains in the population of southern Greece
Pliaka, V.; Ruether, I. G. A.; Kyriakopoulou, Z.; Kioussi, P.; Plakokefalos, E.; Megalou, M.; Pratti, A.; Levidiotou-Stefanou, S.; Markoulatos, P. (2010)P>In this study, the serological status of the southern Greek population in the 1-10-year, 11-20-year, 21-30-year and 31-40 -year age groups with regard to Sabin vaccine strains and a collection of 15 recombinant and four ... -
Sites of disruption within E1 and E2 genes of HPV16 and association with cervical dysplasia
Tsakogiannis, D.; Gortsilas, P.; Kyriakopoulou, Z.; Ruether, I. G. A.; Dimitriou, T. G.; Orfanoudakis, G.; Markoulatos, P. (2015)Integration of HPV16 DNA into the host chromosome usually disrupts the E1 and/or E2 genes. The present study investigated the disruption of E1, E2 genes in a total of eighty four HPV16-positive precancerous and cervical ... -
Use of mutational pattern in 5 '-NCR and VP1 regions of polioviruses for molecular diagnosis
Pliaka, V.; Dedepsidis, E.; Kyriakopoulou, Z.; Papadopoulou, I.; Levidiotou, S.; Markoulatos, P. (2007)Polioviruses are members of the enterovirus genus, belonging to the Picornaviridae family. They are the causative agents of poliomyelitis, a paralytic and sometimes fatal disease in humans. The number of poliomyelitis cases ...