99mTc-sestamibi uptake in rat skeletal muscle and heart: Physiological determinants and correlations
Συγγραφέας
Arsos, G.; Kyparos, A.; Moralidis, E.; Kyparos, D.; Georga, S.; Sotiriadou, S.; Matziari, C.; Karakatsanis, C.Ημερομηνία
2009Λέξη-κλειδί
Επιτομή
The lipophilic cationic radiotracer 99mTc-sestamibi, known to be concentrated within mitochondria, is widely used for myocardial perfusion and to a lesser extent for muscle metabolism imaging. However, the exact distribution pattern in skeletal muscle has not been yet studied in detail. The present study aims to investigate the 99mTc-sestamibi uptake in rat skeletal muscle and myocardium in relation to their metabolic characteristics. 99mTc-sestamibi was i.v. administered in twenty adult male Wistar rats and uptake, as percent of injected dose per tissue gram (%ID/g), in the myocardium, soleus, extensor digitorum longus and gastrocnemius muscles was assessed 2 h after the injection. Muscle uptake was also correlated with myocardial uptake, muscle weight and body weight. Skeletal muscle 99mTc-sestamibi uptake was a small (9-16 %) fraction of that found in myocardium (1.71±0.63 %ID/g). Among the three hindlimb muscles considered, the slow-oxidative soleus muscle showed the highest uptake (0.28±0.16 %ID/g). Metabolically diverse parts of the gastrocnemius muscle showed different uptake. Skeletal muscle uptake was positively correlated with myocardial uptake and both were negatively correlated with tissue and body weight. Skeletal muscle and myocardium 99mTc-sestamibi uptake is related to their metabolic profile. Myocardium, with an exceptional rich mitochondrial concentration, shows much higher 99mTc-sestamibi uptake compared to skeletal muscles. Among muscles, uptake is dependent on their mitochondrial content. Evidence of matching exists between myocardial and muscle uptake, and both are size-dependent. © 2009 by the Institute of Physiology, Czech Academy of Sciences.
Collections
Related items
Showing items related by title, author, creator and subject.
-
Respiratory, cardiac and metabolic responses during electrical muscle stimulation in quadriceps muscle versus comparable voluntary muscle contractions
Kortianou E.A., Papafilippou E.K., Karagkounis A. (2021)Electrical Muscle Stimulation (EMS) and voluntary muscle contraction (VMC) are both acceptable rehabilitative modalities to preserve muscle strength loss. The study aimed to compare respiratory, metabolic, and cardiac ... -
Oxidative Stress in Hypovolemic Shock Alters Electrical and Mechanical Activities in Isolated Rabbit Heart Papillary Muscles
Chaniotis, D. I.; Lymberi, M.; Deliconstantinos, G.; Molyvdas, P. A. (2003)We investigated the electrophysiological and contractile responses of isolated rabbit heart papillary muscles, to plasma from the blood of rabbits suffering prolonged hypovolemic shock (SP) and compared the production of ... -
Left ventricular hypertrophy and sudden cardiac death
Giamouzis G., Dimos A., Xanthopoulos A., Skoularigis J., Triposkiadis F. (2022)Sudden cardiac death (SCD) is among the leading causes of death worldwide, and it remains a public health problem, as it involves young subjects. Current guideline-directed risk stratification for primary prevention is ...