Όλο το DSpace

Εμφάνιση απλής εγγραφής

Evaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter study

dc.creatorWang L., Heckman M.G., Aasly J.O., Annesi G., Bozi M., Chung S.J., Clarke C., Crosiers D., Eckstein G., Garraux G., Hadjigeorgiou G.M., Hattori N., Jeon B., Kim Y.J., Kubo M., Lesage S., Lin J.J., Lynch T., Lichtner P., Mellick G.D., Mok V., Morrison K.E., Quattrone A., Satake W., Silburn P.A., Stefanis L., Stockton J.D., Tan E.K., Toda T., Brice A., Van Broeckhoven C., Uitti R.J., Wirdefeldt K., Wszolek Z., Xiromerisiou G., Maraganore D.M., Gasser T., Krüger R., Farrer M.J., Ross O.A., Sharma M.en
dc.date.accessioned2023-01-31T11:37:21Z
dc.date.available2023-01-31T11:37:21Z
dc.date.issued2017
dc.identifier10.1016/j.neurobiolaging.2016.09.022
dc.identifier.issn01974580
dc.identifier.urihttp://hdl.handle.net/11615/80779
dc.description.abstractA recent study MacLeod et al. has shown that an interaction between variants at the LRRK2 and PARK16 loci influences risk of development of Parkinson's disease (PD). Our study examines the proposed interaction between LRRK2 and PARK16 variants in modifying PD risk using a large multicenter series of PD patients (7715) and controls (8261) from sites participating in the Genetic Epidemiology of Parkinson's Disease Consortium. Our data does not support a strong direct interaction between LRRK2 and PARK16 variants; however, given the role of retromer and lysosomal pathways in PD, further studies are warranted. © 2016 Elsevier Inc.en
dc.language.isoenen
dc.sourceNeurobiology of Agingen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85002145842&doi=10.1016%2fj.neurobiolaging.2016.09.022&partnerID=40&md5=8203cec689d714ba1d25c0292493eba1
dc.subjectleucine rich repeat kinase 2en
dc.subjectleucine rich repeat kinase 2en
dc.subjectLRRK2 protein, humanen
dc.subjectArticleen
dc.subjectcontrolled studyen
dc.subjectgeneen
dc.subjectgene frequencyen
dc.subjectgene interactionen
dc.subjectgene locusen
dc.subjectgenetic risken
dc.subjectgenetic variabilityen
dc.subjectgenotypeen
dc.subjecthumanen
dc.subjectLRRK2 geneen
dc.subjectlysosomeen
dc.subjectmajor clinical studyen
dc.subjectPARK16 geneen
dc.subjectParkinson diseaseen
dc.subjectpriority journalen
dc.subjectsingle nucleotide polymorphismen
dc.subjectepistasisen
dc.subjectgene locusen
dc.subjectgenetic association studyen
dc.subjectgenetic predispositionen
dc.subjectgenetic variationen
dc.subjectgeneticsen
dc.subjectmulticenter study (topic)en
dc.subjectParkinson diseaseen
dc.subjectrisken
dc.subjectEpistasis, Geneticen
dc.subjectGenetic Association Studiesen
dc.subjectGenetic Locien
dc.subjectGenetic Predisposition to Diseaseen
dc.subjectGenetic Variationen
dc.subjectHumansen
dc.subjectLeucine-Rich Repeat Serine-Threonine Protein Kinase-2en
dc.subjectMulticenter Studies as Topicen
dc.subjectParkinson Diseaseen
dc.subjectRisken
dc.subjectElsevier Inc.en
dc.titleEvaluation of the interaction between LRRK2 and PARK16 loci in determining risk of Parkinson's disease: analysis of a large multicenter studyen
dc.typejournalArticleen


Αρχεία σε αυτό το τεκμήριο

ΑρχείαΜέγεθοςΤύποςΠροβολή

Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο.

Αυτό το τεκμήριο εμφανίζεται στις ακόλουθες συλλογές

Εμφάνιση απλής εγγραφής