Homocysteine, B Vitamins, and Cardiovascular Risk

Abstract

Several observational studies have associated homocysteine with atherosclerotic disease. B vitamins, and particularly folic acid, B12 and B6, reduce homocysteine levels effectively. Hence, it was suggested that B vitamin supplementation could reduce cardiovascular risk. However, the results of several randomized clinical trials have not confirmed this hypothesis. This chapter presents the association of homocysteine and B vitamins with cardiovascular risk, and discusses the available data. © 2015 Elsevier Inc. All rights reserved.