dc.creator | Eleftheriadis T., Pissas G., Antoniadi G., Tsogka K., Sounidaki M., Liakopoulos V., Stefanidis I. | en |
dc.date.accessioned | 2023-01-31T07:37:14Z | |
dc.date.available | 2023-01-31T07:37:14Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.3892/mmr.2015.4595 | |
dc.identifier.issn | 17912997 | |
dc.identifier.uri | http://hdl.handle.net/11615/71327 | |
dc.description.abstract | Indoleamine 2,3-dioxygenase (IDO), through L-tryptophan depletion, activates general control non-derepressible (GCN) 2 kinase and suppresses T-cell proliferation, in addition to suppressing aerobic glycolysis and glutaminolysis, which are required for these rapidly proliferating cells. A number of, however not all of these alterations, are partially mediated through IDO-induced p53 upregulation. In two-way mixed lymphocyte reactions (MLRs), IDO reduced cellular proliferation. In MLR-derived T-cells, IDO induced the expression levels of p53 and p21, however concurrently reduced the levels of ζ-chain, c-Myc, lactate dehydrogenase A (LDH-A) and glutaminase (GLS)2. However, p53 had no effect on the expression of the above proteins. These results were recapitulated in T-cells activated with anti-CD2, anti-CD3 and anti-CD28 by direct activation of the GCN2 kinase with tryptophanol. In conclusion, IDO, through GCN2 kinase activation, downregulates the levels of TCR-complex ζ-chain and c-Myc, resulting in the suppression of T-cell proliferation and a reduction in the levels of LDH-A and GLS2, which are key enzymes involved in aerobic glycolysis and glutaminolysis, respectively. | en |
dc.language.iso | en | en |
dc.source | Molecular Medicine Reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954290907&doi=10.3892%2fmmr.2015.4595&partnerID=40&md5=a0091a9f528df9bb958368d0ed14d3b0 | |
dc.subject | CD2 antigen | en |
dc.subject | CD28 antigen | en |
dc.subject | CD3 antigen | en |
dc.subject | glutaminase | en |
dc.subject | indoleamine 2,3 dioxygenase | en |
dc.subject | lactate dehydrogenase | en |
dc.subject | Myc protein | en |
dc.subject | protein p21 | en |
dc.subject | protein p53 | en |
dc.subject | T lymphocyte receptor | en |
dc.subject | T lymphocyte receptor zeta chain | en |
dc.subject | unclassified drug | en |
dc.subject | EIF2AK4 protein, human | en |
dc.subject | GLS2 protein, human | en |
dc.subject | glutaminase | en |
dc.subject | indoleamine 2,3 dioxygenase | en |
dc.subject | lactate dehydrogenase | en |
dc.subject | lymphocyte antigen receptor | en |
dc.subject | Myc protein | en |
dc.subject | p21 activated kinase | en |
dc.subject | protein p53 | en |
dc.subject | protein serine threonine kinase | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | cell viability | en |
dc.subject | down regulation | en |
dc.subject | female | en |
dc.subject | glycolysis | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | lymphocyte proliferation | en |
dc.subject | male | en |
dc.subject | mixed lymphocyte reaction | en |
dc.subject | normal human | en |
dc.subject | peripheral blood mononuclear cell | en |
dc.subject | protein expression | en |
dc.subject | T lymphocyte | en |
dc.subject | T lymphocyte activation | en |
dc.subject | biosynthesis | en |
dc.subject | cell proliferation | en |
dc.subject | genetics | en |
dc.subject | metabolism | en |
dc.subject | mitochondrion | en |
dc.subject | pathology | en |
dc.subject | T lymphocyte | en |
dc.subject | Cell Proliferation | en |
dc.subject | Glutaminase | en |
dc.subject | Glycolysis | en |
dc.subject | Humans | en |
dc.subject | Indoleamine-Pyrrole 2,3,-Dioxygenase | en |
dc.subject | L-Lactate Dehydrogenase | en |
dc.subject | Mitochondria | en |
dc.subject | p21-Activated Kinases | en |
dc.subject | Protein-Serine-Threonine Kinases | en |
dc.subject | Proto-Oncogene Proteins c-myc | en |
dc.subject | Receptors, Antigen, T-Cell | en |
dc.subject | T-Lymphocytes | en |
dc.subject | Tumor Suppressor Protein p53 | en |
dc.subject | Spandidos Publications | en |
dc.title | Indoleamine 2,3-dioxygenase downregulates T-cell receptor complex ζ-chain and c-Myc, and reduces proliferation, lactate dehydrogenase levels and mitochondrial glutaminase in human T-cells | en |
dc.type | journalArticle | en |