dc.creator | Vlachos, I. S. | en |
dc.creator | Kostoulas, N. | en |
dc.creator | Vergoulis, T. | en |
dc.creator | Georgakilas, G. | en |
dc.creator | Reczko, M. | en |
dc.creator | Maragkakis, M. | en |
dc.creator | Paraskevopoulou, M. D. | en |
dc.creator | Prionidis, K. | en |
dc.creator | Dalamagas, T. | en |
dc.creator | Hatzigeorgiou, A. G. | en |
dc.date.accessioned | 2015-11-23T10:53:45Z | |
dc.date.available | 2015-11-23T10:53:45Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1093/nar/gks494 | |
dc.identifier.issn | 0305-1048 | |
dc.identifier.uri | http://hdl.handle.net/11615/34514 | |
dc.description.abstract | MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional analysis has been deemed central in many research pipelines. The new version of DIANA-miRPath web server was redesigned from the ground-up. The user of DNA Intelligent Analysis (DIANA) DIANA-miRPath v2.0 can now utilize miRNA targets predicted with high accuracy based on DIANA-microT-CDS and/or experimentally verified targets from TarBase v6; combine results with merging and meta-analysis algorithms; perform hierarchical clustering of miRNAs and pathways based on their interaction levels; as well as elaborate sophisticated visualizations, such as dendrograms or miRNA versus pathway heat maps, from an intuitive and easy to use web interface. New modules enable DIANA-miRPath server to provide information regarding pathogenic single nucleotide polymorphisms (SNPs) in miRNA target sites (SNPs module) or to annotate all the predicted and experimentally validated miRNA targets in a selected molecular pathway (Reverse Search module). DIANA-miRPath v2.0 is an efficient and yet easy to use tool that can be incorporated successfully into miRNA-related analysis pipelines. It provides for the first time a series of highly specific tools for miRNA-targeted pathway analysis via a web interface and can be accessed at http://www.microrna.gr/miRPathv2. | en |
dc.source | Nucleic Acids Research | en |
dc.source.uri | <Go to ISI>://WOS:000306670900081 | |
dc.subject | MOUSE MICRORNAS | en |
dc.subject | GENES | en |
dc.subject | DISEASES | en |
dc.subject | ENRICHMENT | en |
dc.subject | TARGETS | en |
dc.subject | SYSTEM | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.title | DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways | en |
dc.type | journalArticle | en |