Omalizumab Therapy for Allergic Bronchopulmonary Aspergillosis in Children with Cystic Fibrosis: A Synthesis of Published Evidence

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis (CF) is treated with corticosteroids. Since elevated IgE is a cardinal abnormality, anti-IgE has been used sporadically as adjuvant treatment. In eight case reports, 13 children with CF and ABPA received anti-IgE resulting in improved FEV1, fewer respiratory symptoms and decreased corticosteroid use. Pediatr Pulmonol. 2014; 49:503-507. (c) 2013 Wiley Periodicals, Inc.