Natural agents against neutrophil involvement in H.Pylori induced chronic gastritis

Abstract

Helicobacter pylori infection is one of the widely spread human infections and the major risk for peptic ulcer disease, and gastric cancer and cause for chronic gastric inflammation. The major virulence factors in the development of gastric inflammation are VacA, CagA and HPNAP. HPNAP stimulates the production of reactive oxygen intermediates (ROIs) of human neutrophils and monocytes and promotes neutrophil adhesion to endothelial cells thereby causing mucosal damage. Agents (natural or chemical) inhibiting the HPNAP mediated neutrophil activation might be of great medical importance. According to current published data infiltration of neutrophils and mononuclear cells is significantly decreased due to CAPE mediated NF-kB suppression. In addition, according to our previous investigations AGPs, isolated from Pistacia lentiscus var Chia, inhibit neutrophil activation as well as neutrophil adhesion to endothelial cells. The emerging resistance of H.pylori to antibiotic treatment which provokes treatment failure and re-infection necessitates the investigation towards new forms of prevention and therapy of H.pylori induced chronic gastritis. © 2010 Nova Science Publishers, Inc. All rights reserved.