Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women

Abstract

This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E-2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical efficacy of GnRH antagonists in IVF cycles is determined by the hyperstimulation process. (Fertil Steril (R) 2010;94:1554-6. (C)2010 by American Society for Reproductive Medicine.)