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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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  • Επιστημονικές Δημοσιεύσεις Μελών ΠΘ (ΕΔΠΘ)
  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ.
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Simplified criteria for the diagnosis of autoimmune hepatitis

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Autor
Hennes, E. M.; Zeniya, M.; Czaja, A. J.; Parés, A.; Dalekos, G. N.; Krawitt, E. L.; Bittencourt, P. L.; Porta, G.; Boberg, K. M.; Hofer, H.; Bianchi, F. B.; Shibata, M.; Schramm, C.; De Torres, B. E.; Galle, P. R.; McFarlane, I.; Dienes, H. P.; Lohse, A. W.
Datum
2008
DOI
10.1002/hep.22322
Schlagwort
autoantibody
immunoglobulin G
adult
area under the curve
article
autoimmune hepatitis
clinical practice
cohort analysis
controlled study
diagnostic accuracy
histopathology
human
human tissue
major clinical study
prediction
priority journal
retrospective study
scoring system
sensitivity and specificity
validation process
Area Under Curve
Cohort Studies
Diagnostic Techniques, Digestive System
Gastroenterology
Hepatitis, Autoimmune
Humans
International Cooperation
Middle Aged
Practice Guidelines as Topic
Reproducibility of Results
Retrospective Studies
ROC Curve
Zur Langanzeige
Zusammenfassung
Diagnosis of autoimmune hepatitis (AIH) may be challenging. However, early diagnosis is important because immunosuppression is life-saving. Diagnostic criteria of the International Autoimmune Hepatitis Group (IAIHG) were complex and purely meant for scientific purposes. This study of the IAIHG aims to define simplified diagnostic criteria for routine clinical practice. Candidate criteria included sex, age, autoantibodies, immunoglobulins, absence of viral hepatitis, and histology. The training set included 250 AIH patients and 193 controls from 11 centers worldwide. Scores were built from variables showing predictive ability in univariate analysis. Diagnostic value of each score was assessed by the area under the receiver operating characteristic (ROC) curve. The best score was validated using data of an additional 109 AIH patients and 284 controls. This score included autoantibodies, immunoglobulin G, histology, and exclusion of viral hepatitis. The area under the curve for prediction of AIH was 0.946 in the training set and 0.91 in the validation set. Based on the ROC curves, two cutoff points were chosen. The score was found to have 88% sensitivity and 97% specificity (cutoff ≥6) and 81% sensitivity and 99% specificity (cutoff ≥7) in the validation set. Conclusion: A reliable diagnosis of AIH can be made using a very simple diagnostic score. We propose the diagnosis of probable AIH at a cutoff point greater than 6 points and definite AIH 7 points or higher. Copyright © 2008 by the American Association for the Study of Liver Diseases.
URI
http://hdl.handle.net/11615/28494
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  • Δημοσιεύσεις σε περιοδικά, συνέδρια, κεφάλαια βιβλίων κλπ. [19743]

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