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Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections
dc.creator | Dieguez-Gonzalez, R. | en |
dc.creator | Calaza, M. | en |
dc.creator | Shi, D. | en |
dc.creator | Meulenbelt, I. | en |
dc.creator | Loughlin, J. | en |
dc.creator | Tsezou, A. | en |
dc.creator | Dai, J. | en |
dc.creator | Malizos, K. N. | en |
dc.creator | Slagboom, E. P. | en |
dc.creator | Kloppenburg, M. | en |
dc.creator | Chapman, K. | en |
dc.creator | Jiang, Q. | en |
dc.creator | Kremer, D. | en |
dc.creator | Gomez-Reino, J. J. | en |
dc.creator | Nakajima, N. | en |
dc.creator | Ikegawa, S. | en |
dc.creator | Gonzalez, A. | en |
dc.date.accessioned | 2015-11-23T10:25:27Z | |
dc.date.available | 2015-11-23T10:25:27Z | |
dc.date.issued | 2009 | |
dc.identifier | 10.1136/ard.2008.093641 | |
dc.identifier.issn | 0003-4967 | |
dc.identifier.uri | http://hdl.handle.net/11615/27041 | |
dc.description.abstract | Objectives: To replicate a previously reported association with osteoarthritis (OA) of the promoter single nucleotide polymorphism (SNP) rs10980705 in the endothelial differentiation gene 2 (EDG2). Methods: Five collections of samples, four from Europe and one from China, were studied. They included patients with 3 OA phenotypes: 1501 with knee OA, 1497 with hip OA and 376 with generalised OA. A total of 2521 controls were also studied. Allele and genotype frequencies of the rs10980705 SNP were analysed in each individual sample collection and in pooled data. In addition, a meta-analysis to incorporate results from the original Japanese report was performed. Results: The association of the rs10980705 SNP with knee OA was not replicated in any of the five sample collections studied or in their combined analysis (odds ratio (OR) 1.10, 95% CI 0.98 to 1.22; p = 0.10). Meta-analysis of all data, including the original Japanese study, did show association with knee OA (OR 1.15, 95% CI 1.06 to 1.26; p = 0.002) but the effect was accounted for by the Japanese data and was less significant than the original report. No association was found with hip OA or with generalised OA. Conclusions: The original report of a promising genetic association between a druggable G-protein coupled receptor, EDG2, and knee OA has not been replicated. This lack of replication could be due to a modest effect of the promoter polymorphism that will require even larger studies (the winners curse) although a more pronounced effect in the Asian population vs Europeans cannot be excluded. | en |
dc.source | Annals of the Rheumatic Diseases | en |
dc.source.uri | <Go to ISI>://WOS:000266917100041 | |
dc.subject | RECEPTOR GENES | en |
dc.subject | FUNCTIONAL SNP | en |
dc.subject | D-REPEAT | en |
dc.subject | SUSCEPTIBILITY | en |
dc.subject | ASSOCIATION | en |
dc.subject | METAANALYSIS | en |
dc.subject | DISEASE | en |
dc.subject | POLYMORPHISMS | en |
dc.subject | INFLAMMATION | en |
dc.subject | TARGETS | en |
dc.subject | Rheumatology | en |
dc.title | Testing the druggable endothelial differentiation gene 2 knee osteoarthritis genetic factor for replication in a wide range of sample collections | en |
dc.type | journalArticle | en |
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