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Serum interleukin-1 beta, interleukin-8 and anti-heat shock 60 Chlamydia trachomatis antibodies as markers of ectopic pregnancy
dc.creator | Daponte, A. | en |
dc.creator | Pournaras, S. | en |
dc.creator | Deligeoroglou, E. | en |
dc.creator | Skentou, H. | en |
dc.creator | Messinis, I. E. | en |
dc.date.accessioned | 2015-11-23T10:25:09Z | |
dc.date.available | 2015-11-23T10:25:09Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1016/j.jri.2012.01.003 | |
dc.identifier.issn | 0165-0378 | |
dc.identifier.uri | http://hdl.handle.net/11615/26902 | |
dc.description.abstract | Anti-Chlamydial trachomatis (anti-CT) responses, particularly anti-heat shock 60 (Hsp60), antibodies confer a higher risk of ectopic pregnancy. With emerging evidence supporting the pivotal role of interleukin-1 beta (IL-1 beta) and IL-8 in the immunopathogenesis of CT-specific tubal obstruction, we determined anti-CT Hsp60 antibody reactivity and serum concentrations of IL-1 beta and IL-8 in failed pregnancies consisting of 30 consecutive ectopic pregnancies and 30 missed abortions, with 32 viable intrauterine pregnancies tested as normal controls. ELISAs were utilised to measure IgA or IgG anti-CT major outer membrane outer protein (MOMP) antibodies, IgG anti-CT Hsp60 antibodies and IL-1 beta and IL-8. IgG anti-CT Hsp60 antibodies were more prevalent in ectopic pregnancy cases (43.3%, 13/30) than in intrauterine pregnancies (16%, 5/32, p = 0.016). All 13 ectopic pregnancy anti-CT Hsp60-positive cases had anti-CT MOMP antibodies. CT-specific antibodies were more frequent in merged ectopic pregnancy and missed abortions cases (35%, 21/60) than in intrauterine pregnancies (16%, p = 0.049). The median (range) levels of IL-1 beta in ectopic pregnancy, missed abortions and normal intrauterine pregnancies were 1.74 (0.2-8.7), 1.14 (0.2-16) and 1.22 (0.2-16.2) pg/ml, respectively (p > 0.05, for all). Serum IL-8 levels were comparable amongst groups: ectopic pregnancy (median [range]: 25.1 [18.3-1000]); missed abortions (32.9 [15.39-1000]); and intrauterine pregnancies (25.11 [18.3-1000] pg/ml). Anti-CT antibody-positive ectopic pregnancy had significantly lower IL-1 beta levels (1.29 [0.2-2.93]) pg/ml than sero-negative ectopic pregnancy cases (2.09 [1.10-8.70]) pg/ml, (p = 0.022), but IL-8 did not differ. Our data demonstrate that anti-CT Hsp60 immunity is a predominant feature of ectopic pregnancy. We conclude that neither IL-1 beta nor IL-8 can be considered markers of failed pregnancy, although lower levels of the former cytokine are associated with CT-related ectopic pregnancy. (C) 2012 Elsevier Ireland Ltd. All rights reserved. | en |
dc.source | Journal of Reproductive Immunology | en |
dc.source.uri | <Go to ISI>://WOS:000302501100005 | |
dc.subject | Interleukin 1beta (IL-1 beta) | en |
dc.subject | Interleukin 8 (IL-8) | en |
dc.subject | Anti-heat shock 60 | en |
dc.subject | Chlamydia trachomatis | en |
dc.subject | Abortion | en |
dc.subject | Ectopic pregnancy | en |
dc.subject | Biomarker | en |
dc.subject | IN-VITRO FERTILIZATION | en |
dc.subject | MESSENGER-RNA | en |
dc.subject | DEOXYRIBONUCLEIC-ACID | en |
dc.subject | PRETERM | en |
dc.subject | BIRTH | en |
dc.subject | INFECTION | en |
dc.subject | PROTEIN | en |
dc.subject | EXPRESSION | en |
dc.subject | WOMEN | en |
dc.subject | DISEASE | en |
dc.subject | SYSTEM | en |
dc.subject | Immunology | en |
dc.subject | Reproductive Biology | en |
dc.title | Serum interleukin-1 beta, interleukin-8 and anti-heat shock 60 Chlamydia trachomatis antibodies as markers of ectopic pregnancy | en |
dc.type | journalArticle | en |
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