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    • Arthritis and Myositis in a Patient Treated with Programmed Cell Death-1 (PD-1) Inhibitor Pembrolizumab for Lung Cancer 

      Pagkopoulou E., Simopoulou T., Maragkouli E., Perifanou-Sotiri S., Kotsakis A., Bogdanos D.P. (2020)
      Immune checkpoint inhibitors (ICIs) are a new class of drug that have demonstrated efficacy across many cancer types. Because of their nature and mode of action, ICIs unleash immune activation raising concerns as to whether ...

    • Association of anti-CCP positivity and carriage of TNFRII susceptibility variant with anti-TNF-α response in rheumatoid arthritis 

      Vasilopoulos, Y.; Bagiatis, V.; Stamatopoulou, D.; Zisopoulos, D.; Alexiou, I.; Sarafidou, T.; Settas, L.; Sakkas, L.; Mamuris, Z. (2011)
      Objective: To investigate the possible influence of tumour necrosis factoralpha (TNF), TNF receptor I (TNFRI) and TNF receptor II (TNFRII) gene polymorphisms on anti-TNF treatment responsiveness, stratified by autoantibody ...

    • Association of FCGR2A with the response to infliximab treatment of patients with rheumatoid arthritis 

      Montes, A.; Perez-Pampin, E.; Narváez, J.; Cañete, J. D.; Navarro-Sarabia, F.; Moreira, V.; Fernández-Nebro, A.; Del Carmen Ordóñez, M.; De La Serna, A. R.; Magallares, B.; Vasilopoulos, Y.; Sarafidou, T.; Caliz, R.; Ferrer, M. A.; Joven, B.; Carreira, P.; Gómez-Reino, J. J.; Gonzalez, A. (2014)
      OBJECTIVES: We aimed to assess a functional polymorphism in FCGR2A H131R, for association with the treatment response to Fc-containing inhibitors of tumor necrosis factor (TNF). METHODS: A total of 429 biologic-naive ...

    • Bing–Neel syndrome presenting with bilateral lumbar radiculopathy: A case report of a rare clinical entity [Síndrome de Bing-Neel que se presenta con radiculopatía lumbar bilateral: reporte de caso de una entidad clínica rara] 

      Brotis A.G., Palassopoulou M., Kapsalaki E.Z., Paschalis T., Papastergiou V., Fountas K.N. (2022)
      The differential diagnosis of bilateral lower extremity weakness is broad. We present a very rare case of a 48-year old male patient, with walking difficulties due to Bing–Neel syndrome. On clinical examination, there was ...

    • Biologics in SAPHO syndrome: A systematic review 

      Daoussis D., Konstantopoulou G., Kraniotis P., Sakkas L., Liossis S.-N. (2019)
      Background: The SAPHO syndrome is a relatively rare clinical entity characterized by a wide range of dermatological and musculoskeletal manifestations. Biologics have been used in cases refractory to conventional treatment. ...

    • Cancer-associated stroke: Pathophysiology, detection and management (Review) 

      Dardiotis E., Aloizou A.-M., Markoula S., Siokas V., Tsarouhas K., Tzanakakis G., Libra M., Kyritsis A.P., Brotis A.G., Aschner M., Gozes I., Bogdanos D.P., Spandidos D.A., Mitsias P.D., Tsatsakis A. (2019)
      Numerous types of cancer have been shown to be associated with either ischemic or hemorrhagic stroke. In this review, the epidemiology and pathophysiology of stroke in cancer patients is discussed, while providing vital ...

    • Cardiorespiratory fitness and physical activity in people who have rheumatoid arthritis at an increased risk of cardiovascular disease: a cross-sectional study 

      Sobejana M., van den Hoek J., Metsios G.S., Kitas G.D., Jorstad H.T., van der Leeden M., Pijnappels M., Lems W.F., Nurmohamed M.T., van der Esch M. (2021)
      Lower cardiorespiratory fitness (CRF) and physical activity (PA) associate with higher cardiovascular disease (CVD) risk, but the relationship between CRF and PA in people who have rheumatoid arthritis (RA) at an increased ...

    • Children with psoriasis and COVID-19: factors associated with an unfavourable COVID-19 course, and the impact of infection on disease progression (Chi-PsoCov registry) 

      Zitouni J., Bursztejn A.-C., Belloni Fortina A., Beauchet A., Di Lernia V., Lesiak A., Thomas J., Topkarci Z., Murashkin N., Brzezinski P., Torres T., Chiriac A., Luca C., McPherson T., Akinde M., Maruani A., Epishev R., Vidaurri de la Cruz H., Luna P.C., Amy de la Bretêque M., Lasek A., Bourrat E., Bachelerie M., Mallet S., Steff M., Bellissen A., Neri I., Zafiriou E., van den Reek J.M.P.A., Sonkoly E., Mahil S.K., Smith C.H., Flohr C., Bachelez H., Mahé E., the Groupe de Recherche sur le Psoriasis (GrPso) of the Societe Francaise de Dermatologie, the Groupe de recherche de la Societe Francaise de Dermatologie Pediatrique (GR SFDP), the PsoProtect study group, the British Society of Paediatric Dermatology (BPSD), and the Societa Italiana di Dermatologia Pediatrica (S.I.Der.P.) (2022)
      Background: The COVID-19 pandemic has raised questions regarding the management of chronic skin diseases, especially in patients on systemic treatments. Data concerning the use of biologics in adults with psoriasis are ...

    • The Collaborative Ocular Tuberculosis Study (COTS)-1 Report 3: Polymerase Chain Reaction in the Diagnosis and Management of Tubercular Uveitis: Global Trends 

      Agarwal A., Agrawal R., Gunasekaran D.V., Raje D., Gupta B., Aggarwal K., Murthy S.L., Westcott M., Chee S.P., McCluskey P., Ling H.S., Teoh S., Cimino L., Biswas J., Narain S., Agarwal M., Mahendradas P., Khairallah M., Jones N., Tugal-Tutkun I., Babu K., Basu S., Carreño E., Lee R., Al-Dhibi H., Bodaghi B., Invernizzi A., Goldstein D.A., Herbort C.P., Barisani-Asenbauer T., González-López J.J., Androudi S., Bansal R., Moharana B., Mahajan S., Esposti S., Tasiopoulou A., Nadarajah S., Agarwal M., Abraham S., Vala R., Singh R., Sharma A., Sharma K., Zierhut M., Kon O.M., Cunningham E., Nguyen Q.D., Pavesio C., Gupta V. (2019)
      Purpose: To analyze the role of polymerase chain reaction (PCR) of ocular fluids in management of tubercular (TB) anterior, intermediate, posterior, and panuveitis. Methods: In Collaborative Ocular Tuberculosis Study ...

    • A comprehensive analysis of antigen-specific antibody responses against human cytomegalovirus in patients with systemic sclerosis 

      Efthymiou G., Dardiotis E., Liaskos C., Marou E., Scheper T., Meyer W., Daponte A., Daoussis D., Hadjigeorgiou G., Bogdanos D.P., Sakkas L.I. (2019)
      Anti-human cytomegalovirus (HCMV) antibodies are considered triggers of systemic sclerosis (SSc), but such a hypothesis has been assessed in limited sub-dominant epitopes. Our aim was to systematically assess the potential ...

    • The efficacy of immunomodulators in the prevention and suppression of anti-drug antibodies to anti-tumor necrosis factor therapy in inflammatory bowel disease 

      Fousekis F.S., Papamichael K., Kourtis G., Albani E.N., Orfanidou A., Saridi M., Katsanos K.H., Christodoulou D.K. (2022)
      The development of biological agents against tumor necrosis factor (TNF) has revolutionized the management of inflammatory bowel disease (IBD), frequently achieving induction and maintenance of remission in both ulcerative ...

    • Exercise intervention on cardiorespiratory fitness in rheumatoid arthritis patients with high cardiovascular disease risk: a single-arm pilot study 

      Sobejana M., van den Hoek J., Metsios G.S., Kitas G.D., van der Leeden M., Verberne S., Jorstad H.T., Pijnappels M., Lems W.F., Nurmohamed M.T., van der Esch M. (2022)
      Objective: In patients with rheumatoid arthritis (RA) with cardiovascular disease risk, it is unknown whether exercises are safe, improve cardiorespiratory fitness and reduce disease-related symptoms and cardiovascular-disease ...

    • Hematogenous spinal infection in Central Greece 

      Sakkas, L. I.; Davas, E. M.; Kapsalaki, E.; Boulbou, M.; Makaritsis, K.; Alexiou, I.; Tsikrikas, T.; Stathakis, N. (2009)
      STUDY DESIGN.: We retrospectively analyzed spinal infection (SpI), in a teaching Hospital, in Central Greece. OBJECTIVE.: To study presentation, etiology, and outcome of SpI in Central Greece. SUMMARY OF BACKGROUND DATA.: ...

    • How can we effectively address the paraneoplastic dermatomyositis: Diagnosis, risk factors and treatment options 

      Zerdes I., Tolia M., Nikolaou M., Tsoukalas N., Velentza L., Hajiioannou J., Mitsis M., Kyrgias G. (2017)
      Purpose: Dermatomyositis (DM) represents an auto-immune inflammatory myopathy. In this review, we analyzed the incidence of DM as a clinical manifestation highlighting the peculiar clinical and treatment characteristics ...

    • Human cytomegalovirus (HCMV) UL44 and UL57 specific antibody responses in anti-HCMV-positive patients with systemic sclerosis 

      Marou E., Liaskos C., Simopoulou T., Efthymiou G., Dardiotis E., Katsiari C., Scheper T., Meyer W., Hadjigeorgiou G., Bogdanos D.P., Sakkas L.I. (2017)
      The role of human cytomegalovirus (HCMV) has been postulated as a trigger of systemic sclerosis (SSc). The aim of the study was to assess the prevalence of antibodies against HCMV UL44 and UL57 antigens not tested in the ...

    • Identification of Very Low-Risk Subgroups of Patients with Primary Mediastinal Large B-Cell Lymphoma Treated with R-CHOP 

      Vassilakopoulos T.P., Michail M., Papageorgiou S., Kourti G., Angelopoulou M.K., Panitsas F., Sachanas S., Kalpadakis C., Katodritou E., Leonidopoulou T., Kotsianidis I., Hatzimichael E., Kotsopoulou M., Dimou M., Variamis E., Boutsis D., Terpos E., Dimopoulou M.N., Karakatsanis S., Michalis E., Karianakis G., Tsirkinidis P., Vadikolia C., Poziopoulos C., Pigaditou A., Vrakidou E., Economopoulos T., Kyriazopoulou L., Siakantaris M.P., Kyrtsonis M.-C., Symeonidis A., Anargyrou K., Papaioannou M., Hatjiharissi E., Vervessou E., Tsirogianni M., Palassopoulou M., Gainaru G., Stefanoudaki E., Zikos P., Tsirigotis P., Tsourouflis G., Assimakopoulou T., Konstantinidou P., A. Papadaki H., Megalakaki K., Dimopoulos M.-A., Pappa V., Karmiris T., Roussou P., Panayiotidis P., Konstantopoulos K., Pangalis G.A. (2021)
      Background: R-CHOP can cure approximately 75% of patients with primary mediastinal large B-cell lymphoma (PMLBCL), but prognostic factors have not been sufficiently evaluated yet. R-da- EPOCH is potentially more effective ...

    • IL-10-producing regulatory B cells (B10 cells), IL-17 + T cells and autoantibodies in systemic sclerosis 

      Mavropoulos A., Liaskos C., Simopoulou T., Bogdanos D.P., Sakkas L.I. (2017)
      We aimed to analyze IL-10 + Breg (B10) cells, found to be reduced in systemic sclerosis (SSc), in relation to SSc-specific autoAbs and IL-17 + and IFNγ + T cells in SSc. Peripheral blood B10 cells from 26 patients with SSc ...

    • Immunotherapy of systemic sclerosis 

      Katsiari C.G., Simopoulou T., Alexiou I., Sakkas L.I. (2018)
      Systemic sclerosis (SSc) is a chronic systemic disease characterized by microvasculopathy, immune activation, and extensive collagen deposition. Microvasculopathy and immune activation occur very early in the disease ...

    • Incidence, risk factors and validation of the RABBIT score for serious infections in a cohort of 1557 patients with rheumatoid arthritis 

      Thomas K., Lazarini A., Kaltsonoudis E., Voulgari P.V., Drosos A.A., Repa A., Sali A.M.I., Sidiropoulos P., Tsatsani P., Gazi S., Evangelia A., Boki K.A., Katsimbri P., Boumpas D., Fragkiadaki K., Tektonidou M.G., Sfikakis P.P., Karagianni K., Sakkas L.I., Grika E.P., Vlachoyiannopoulos P.G., Evangelatos G., Iliopoulos A., Dimitroulas T., Garyfallos A., Melissaropoulos K., Georgiou P., Areti M., Georganas C., Vounotrypidis P., Georgiopoulos G., Kitas G.D., Vassilopoulos D. (2021)
      Objectives: Predicting serious infections (SI) in patients with rheumatoid arthritis (RA) is crucial for the implementation of appropriate preventive measures. Here we aimed to identify risk factors for SI and to validate ...

    • Index of Suspicion 

      Nazarian; Kaditis, A. G.; Papadimitriou, E.; Alexopoulos, E.; Skenteris, N.; Gidvani, V. K.; Crouch, G.; Pino, J.; Baptist, E. C.; Deol, K. K.; Nageswaran, S.; Glock, M. S.; Hill, I. D.; Ermis, B.; Ors, R.; Kardas, F. (2004)