Sfoglia per Soggetto "transcriptome"

Antimicrobial activity of bee-collected pollen and beebread: State of the art and future perspectives

Didaras N.A., Karatasou K., Dimitriou T.G., Amoutzias G.D., Mossialos D. (2020)

Bee-collected pollen (BCP) is a well-known functional food. Honey bees process the collected pollen and store it in the hive, inside the comb cells. The processed pollen is called beebread or ambrosia and it is the main ...

A data-driven hypothesis on the epigenetic dysregulation of host metabolism by SARS coronaviral infection: Potential implications for the SARS-CoV-2 modus operandi

Vavougios G.D. (2020)

COVID-19, the disease caused by the novel SARS-CoV-2, a betacoronavirus structurally similar to SARS-CoV. Based on both structural and syndromic similarities with SARS-CoV, a hypothesis is formed on SARS-CoV-2 potential ...

Decoding the reproductive system of the olive fruit fly, Bactrocera oleae

Gregoriou M.-E., Reczko M., Kakani E.G., Tsoumani K.T., Mathiopoulos K.D. (2021)

In most diploid organisms, mating is a prerequisite for reproduction and, thus, critical to the maintenance of their population and the perpetuation of the species. Besides the importance of understanding the fundamentals ...

DIANA-miTED: A microRNA tissue expression database

Kavakiotis I., Alexiou A., Tastsoglou S., Vlachos I.S., Hatzigeorgiou A.G. (2022)

microRNAs (miRNAs) are short (∼23nt) single-stranded non-coding RNAs that act as potent post-transcriptional gene expression regulators. Information about miRNA expression and distribution across cell types and tissues is ...

Epigenetic regulation of apoptosis via the PARK7 interactome in peripheral blood mononuclear cells donated by tuberculosis patients vs. healthy controls and the response to treatment: A systems biology approach

Vavougios G.D., Zarogiannis S.G., Krogfelt K.A., Stamoulis G., Gourgoulianis K.I. (2020)

Aims: The aims of our study were to determine for the first time differentially expressed genes (DEGs) and enriched molecular pathways involving the PARK7 interactome in PBMCs donated from tuberculosis patients. Methods: ...

Gene Expression Meta-Analysis of Potential Shared and Unique Pathways between Autoimmune Diseases under Anti-TNFα Therapy

Antonatos C., Panoutsopoulou M., Georgakilas G.K., Evangelou E., Vasilopoulos Y. (2022)

While anti-TNFα has been established as an effective therapeutic approach for several autoimmune diseases, results from clinical trials have uncovered heterogeneous patients’ response to therapy. Here, we conducted a ...

Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis

Bartosova M., Zhang C., Schaefer B., Herzog R., Ridinger D., Damgov I., Levai E., Marinovic I., Eckert C., Romero P., Sallay P., Ujszaszi A., Unterwurzacher M., Wagner A., Hildenbrand G., Warady B.A., Schaefer F., Zarogiannis S.G., Kratochwill K., Schmitt C.P. (2021)

RATIONALE: Patients with chronic kidney disease (CKD) have an exceedingly high cardiovascular risk; which further increases in patients on peritoneal dialysis (PD). The pathophysiological role of reactive metabolites ...

Human coronaviruses in idiopathic Parkinson's disease: Implications of SARS-CoV-2's modulation of the host's transcriptome

Vavougios G.D. (2021)

Objective: A recent study on the effects of SARS-CoV-2 infection on the host's transcriptome indicated the perturbation of several pathways associated with neurodegeneration, including but not limited to Parkinson's and ...

Identification of gene expression profiles in myocardial infarction: A systematic review and meta-analysis

Kontou P., Pavlopoulou A., Braliou G., Bogiatzi S., Dimou N., Bangalore S., Bagos P. (2018)

Background: Myocardial infarction (MI) is a multifactorial disease with complex pathogenesis, mainly the result of the interplay of genetic and environmental risk factors. The regulation of thrombosis, inflammation and ...

Identification of the abiotic stress-related transcription in little Neptune grass Cymodocea nodosa with RNA-seq

Malandrakis E., Dadali O., Kavouras M., Danis T., Panagiotaki P., Miliou H., Tsioli S., Orfanidis S., Küpper F.C., Exadactylos A. (2017)

Seagrasses exhibit vital ecological roles in the marine environment. Nevertheless, the genomic resources available for seagrasses are still scarce. In the present study, the transcriptome of Cymodocea nodosa was sequenced ...

Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients

Vavougios G.D., Ntoskas K.T., Doskas T.K. (2021)

Coagulopathy has recently been recognized as a recurring complication of COVID-19, most typically associated with critical illness. There are epidemiological, mechanistic and transcriptomic evidence that link Selenium with ...

In silico methods for the identification of diagnostic and favorable prognostic markers in acute myeloid leukemia

Yılmaz H., Toy H.I., Marquardt S., Karakülah G., Küçük C., Kontou P.I., Logotheti S., Pavlopoulou A. (2021)

Acute myeloid leukemia (AML), the most common type of acute leukemia in adults, is mainly asymptomatic at early stages and progresses/recurs rapidly and frequently. These attributes necessitate the identification of ...

In silico transcriptomic analysis of the chloride intracellular channels (Clic) interactome identifies a molecular panel of seven prognostic markers in patients with pancreatic ductal adenocarcinoma

Magouliotis D.E., Sakellaridis N., Dimas K., Tasiopoulou V.S., Svokos K.A., Svokos A.A., Zacharoulis D. (2020)

Background: Pancreatic ductal adenocarcinoma (PDAC) is associated with poor prognosis. In this context, the identification of biomarkers regarding the PDAC diagnosis, monitoring, and prognosis is crucial. Objectives: The ...

In vivo base editing by a single i.v. vector injection for treatment of hemoglobinopathies

Li C., Georgakopoulou A., Newby G.A., Everette K.A., Nizamis E., Paschoudi K., Vlachaki E., Gil S., Anderson A.K., Koob T., Huang L., Wang H., Kiem H.-P., Liu D.R., Yannaki E., Lieber A. (2022)

Individuals with β-thalassemia or sickle cell disease and hereditary persistence of fetal hemoglobin (HPFH) possessing 30% fetal hemoglobin (HbF) appear to be symptom free. Here, we used a nonintegrating HDAd5/35++ vector ...

Influence of ROBO1 and RORA on risk of age-related macular degeneration reveals genetically distinct phenotypes in disease pathophysiology

Jun, G.; Nicolaou, M.; Morrison, M. A.; Buros, J.; Morgan, D. J.; Radeke, M. J.; Yonekawa, Y.; Tsironi, E. E.; Kotoula, M. G.; Zacharaki, F.; Mollema, N.; Yuan, Y.; Miller, J. W.; Haider, N. B.; Hageman, G. S.; Kim, I. K.; Schaumberg, D. A.; Farrer, L. A.; DeAngelis, M. M. (2011)

ROBO1 is a strong candidate gene for age-related macular degeneration (AMD) based upon its location under a linkage peak on chromosome 3p12, its expression pattern, and its purported function in a pathway that includes ...

Investigating Molecular Determinants of Cancer Cell Resistance to Ionizing Radiation Through an Integrative Bioinformatics Approach

Toy H.I., Karakülah G., Kontou P.I., Alotaibi H., Georgakilas A.G., Pavlopoulou A. (2021)

Eradication of cancer cells through exposure to high doses of ionizing radiation (IR) is a widely used therapeutic strategy in the clinical setting. However, in many cases, cancer cells can develop remarkable resistance ...

LaGomiCs - Lagomorph Genomics Consortium: An International Collaborative Effort for Sequencing the Genomes of an Entire Mammalian Order

Fontanesi L., Di Palma F., Flicek P., Smith A.T., Thulin C.-G., Alves P.C., Abrantes J., Andersson L., Angelone C., Boonstra R., Campos R., Carneiro M., Casadio R., Cervantes F.A., Dahal N., Djan M., Esteves P.J., Etherington G., Fan J., Fickel J., Ge D., Husband T., King T., Kovach A.I., Lavazza A., Letty J., Lissovsky A.A., Mage R., Mamuris Z., Martelli P.L., McGreevy T., Jr., Melo-Ferreira J., Muffato M., Ramakrishnan U., Randi E., Reid N., Ribani A., Robinson T.J., Russello M.A., Schiavo G., Schneider-Gricar V., Solari K.A., Streeter I., Tizzani P., Tur A., Utzeri V.J., Velickovic N., Vernesi C., Yang Q., Lagomorph Genomics Consortium (2016)

The order Lagomorpha comprises about 90 living species, divided in 2 families: the pikas (Family Ochotonidae), and the rabbits, hares, and jackrabbits (Family Leporidae). Lagomorphs are important economically and scientifically ...