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Πλοήγηση ανά Θέμα "RNA sequence"

Αποτελέσματα 1-20 από 21

    • Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework 

      Mentis A.-F.A., Dardiotis E., Chrousos G.P. (2021)
      The potential existence and roles of the meningeal lymphatic system in normal and pathological brain function have been a long-standing enigma. Recent evidence suggests that meningeal lymphatic vessels are present in both ...

    • Biochemical and in silico identification of the active site and the catalytic mechanism of the circadian deadenylase HESPERIN 

      Beta R.A.A., Kyritsis A., Douka V., Papanastasi E., Rizouli M., Leonidas D.D., Vlachakis D., Balatsos N.A.A. (2022)
      The 24-h molecular clock is based on the stability of rhythmically expressed transcripts. The shortening of the poly(A) tail of mRNAs is often the first and rate-limiting step that determines the lifespan of a mRNA and is ...

    • Cadherin and Wnt signaling pathways as key regulators in diabetic nephropathy 

      Tziastoudi M., Tsezou A., Stefanidis I. (2021)
      Aim A recent meta-analysis of genome-wide linkage studies (GWLS) has identified multiple genetic regions suggestive of linkage with DN harboring hundreds of genes. Moving this number of genetic loci forward into biological ...

    • Case Report of Transmissible Gastroenteritis Coronavirus Infection Associated with Small Intestine and Brain Lesions in Piglets 

      Papatsiros V.G., Stylianaki I., Papakonstantinou G., Papaioannou N., Christodoulopoulos G. (2019)
      This case study report describes a transmissible gastroenteritis coronavirus (TGEV) infection presented in a commercial pig herd. The clinical signs of infection appeared in newborn piglets, including medium morbidity and ...

    • DIANA-LncBase v2: Indexing microRNA targets on non-coding transcripts 

      Paraskevopoulou M.D., Vlachos I.S., Karagkouni D., Georgakilas G., Kanellos I., Vergoulis T., Zagganas K., Tsanakas P., Floros E., Dalamagas T., Hatzigeorgiou A.G. (2016)
      MicroRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) have been recently reported to interact with miRNAs. The sponge-like ...

    • DIANA-LncBase v3: Indexing experimentally supported miRNA targets on non-coding transcripts 

      Karagkouni D., Paraskevopoulou M.D., Tastsoglou S., Skoufos G., Karavangeli A., Pierros V., Zacharopoulou E., Hatzigeorgiou A.G. (2020)
      DIANA-LncBase v3.0 (www.microrna.gr/LncBase) is a reference repository with experimentally supported miRNA targets on non-coding transcripts. Its third version provides approximately half a million entries, corresponding ...

    • ERS International Congress 2021: highlights from the Thoracic Surgery and Lung Transplantation Assembly 

      Bos S., Ricciardi S., Caruana E.J., Öztürk N.A.A., Magouliotis D., Pompili C., Migliore M., Vos R., Meloni F., Elia S., Hellemons M. (2022)
      The thoracic surgery and lung transplantation assembly of the European Respiratory Society (ERS) is delighted to present the highlights from the 2021 ERS International Congress. We have selected four sessions that discussed ...

    • Functional analysis of miRNAs using the DIANA tools online suite 

      Vlachos I.S., Hatzigeorgiou A.G. (2017)
      microRNAs (miRNAs) are central regulators of gene expression. They are actively studied for their involvement in numerous physiological and pathological conditions but also as diagnostic biomarkers or promising therapeutic ...

    • HDAC7 is a major contributor in the pathogenesis of infant t(4;11) proB acute lymphoblastic leukemia 

      de Barrios O., Galaras A., Trincado J.L., Azagra A., Collazo O., Meler A., Agraz-Doblas A., Bueno C., Ballerini P., Cazzaniga G., Stam R.W., Varela I., De Lorenzo P., Valsecchi M.G., Hatzis P., Menéndez P., Parra M. (2021)
      [No abstract available]

    • The human GPCR signal transduction network 

      Kontou P., Pavlopoulou A., Dimou N., Theodoropoulou M., Braliou G., Tsaousis G., Pavlopoulos G., Hamodrakas S., Bagos P. (2021)
      The eukaryotic cell surface G protein-coupled receptors (GPCRs) interact with a wide spectrum of ligands. The intracellular transmission of the extracellular signal is mediated by the selective coupling of GPCRs to G ...

    • Identifying pri-miRNA transcription start sites 

      Georgakilas G., Perdikopanis N., Hatzigeorgiou A.G. (2018)
      MicroRNAs (miRNAs) are small non-coding RNAs that can regulate gene expression playing vital role in nearly all biological pathways. Even though miRNAs have been intensely studied for more than two decades, information ...

    • Impact of Interleukin 10 Deficiency on Intestinal Epithelium Responses to Inflammatory Signals 

      Papoutsopoulou S., Pollock L., Walker C., Tench W., Samad S.S., Bergey F., Lenzi L., Sheibani-Tezerji R., Rosenstiel P., Alam M.T., Martins Dos Santos V.A.P., Müller W., Campbell B.J. (2021)
      Interleukin 10 (IL-10) is a pleiotropic, anti-inflammatory cytokine that has a major protective role in the intestine. Although its production by cells of the innate and adaptive immune system has been extensively studied, ...

    • Late HDV RNA relapse after peginterferon alpha-based therapy of chronic hepatitis delta 

      Heidrich, B.; Yurdaydin, C.; Kabaçam, G.; Ratsch, B. A.; Zachou, K.; Bremer, B.; Dalekos, G. N.; Erhardt, A.; Tabak, F.; Yalcin, K.; Gürel, S.; Zeuzem, S.; Cornberg, M.; Bock, C. T.; Manns, M. P.; Wedemeyer, H. (2014)
      Interferon alpha is the only treatment option for hepatitis delta virus (HDV). Trials investigating the efficacy of pegylated interferon alpha (PEG-IFNa) showed HDV RNA negativity rates of 25-30% 24 weeks after therapy. ...

    • microCLIP super learning framework uncovers functional transcriptome-wide miRNA interactions 

      Paraskevopoulou M.D., Karagkouni D., Vlachos I.S., Tastsoglou S., Hatzigeorgiou A.G. (2018)
      Argonaute crosslinking and immunoprecipitation (CLIP) experiments are the most widely used high-throughput methodologies for miRNA targetome characterization. The analysis of Photoactivatable Ribonucleoside-Enhanced (PAR) ...

    • Myeloid-derived suppressor cells in prostate cancer: Present knowledge and future perspectives 

      Koinis F., Xagara A., Chantzara E., Leontopoulou V., Aidarinis C., Kotsakis A. (2022)
      Several lines of research are being investigated to better understand mechanisms implicated in response or resistance to immune checkpoint blockade in prostate cancer (PCa). Myeloid-derived suppressor cells (MDSCs) have ...

    • Occurrence and molecular characterization of betanodaviruses in fish and invertebrates of the Greek territorial waters 

      Bitchava K., Chassalevris T., Lampou E., Athanassopoulou F., Economou V., Dovas C.I. (2019)
      Betanodaviruses are small ssRNA viruses that cause viral encephalopathy and retinopathy, a severe neuropathological infectious disease in marine fish species worldwide. In the present study, the occurrence of betanodaviruses ...

    • RNAcentral: A comprehensive database of non-coding RNA sequences 

      Petrov A.I., Kay S.J.E., Kalvari I., Howe K.L., Gray K.A., Bruford E.A., Kersey P.J., Cochrane G., Finn R.D., Bateman A., Kozomara A., Griffiths-Jones S., Frankish A., Zwieb C.W., Lau B.Y., Williams K.P., Chan P.P., Lowe T.M., Cannone J.J., Gutell R.R., Machnicka M.A., Bujnicki J.M., Yoshihama M., Kenmochi N., Chai B., Cole J.R., Szymanski M., Karlowski W.M., Wood V., Huala E., Berardini T.Z., Zhao Y., Chen R., Zhu W., Paraskevopoulou M.D., Vlachos I.S., Hatzigeorgiou A.G., Ma L., Zhang Z., Puetz J., Stadler P.F., McDonald D., Basu S., Fey P., Engel S.R., Cherry J.M., Volders P.-J., Mestdagh P., Wower J., Clark M., Quek X.C., Dinger M.E., The RNAcentral Consortium (2017)
      RNAcentral is a database of non-coding RNA (ncRNA) sequences that aggregates data from specialised ncRNA resources and provides a single entry point for accessing ncRNA sequences of all ncRNA types from all organisms. Since ...

    • RNAcentral: A hub of information for non-coding RNA sequences 

      Sweeney B.A., Petrov A.I., Burkov B., Finn R.D., Bateman A., Szymanski M., Karlowski W.M., Gorodkin J., Seemann S.E., Cannone J.J., Gutell R.R., Fey P., Basu S., Kay S., Cochrane G., Billis K., Emmert D., Marygold S.J., Huntley R.P., Lovering R.C., Frankish A., Chan P.P., Lowe T.M., Bruford E., Seal R., Vandesompele J., Volders P.-J., Paraskevopoulou M., Ma L., Zhang Z., Griffiths-Jones S., Bujnicki J.M., Boccaletto P., Blake J.A., Bult C.J., Chen R., Zhao Y., Wood V., Rutherford K., Rivas E., Cole J., Laulederkind S.J.F., Shimoyama M., Gillespie M.E., Orlic-Milacic M., Kalvari I., Nawrocki E., Engel S.R., Cherry J.M., Team S., Berardini T.Z., Hatzigeorgiou A., Karagkouni D., Howe K., Davis P., Dinger M., He S., Yoshihama M., Kenmochi N., Stadler P.F., Williams K.P. (2019)
      RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences of all types from a broad range of organisms. We have recently added a new genome mapping pipeline that ...

    • A systems biology approach uncovers cell-specific gene regulatory effects of genetic associations in multiple sclerosis 

      Madireddy L., Patsopoulos N.A., Cotsapas C., Bos S.D., Beecham A., McCauley J., Kim K., Jia X., Santaniello A., Caillier S.J., Andlauer T.F.M., Barcellos L.F., Berge T., Bernardinelli L., Martinelli-Boneschi F., Booth D.R., Briggs F., Celius E.G., Comabella M., Comi G., Cree B.A.C., D’Alfonso S., Dedham K., Duquette P., Efthimios D., Esposito F., Fontaine B., Gasperi C., Goris A., Dubois B., Gourraud P.-A., Hadjigeorgiou G., Haines J., Hawkins C., Hemmer B., Hintzen R., Horakova D., Isobe N., Kalra S., Kira J.-I., Khalil M., Kockum I., Lill C.M., Lincoln M.R., Luessi F., Martin R., Oturai A., Palotie A., Pericak-Vance M.A., Henry R., Saarela J., Ivinson A., Olsson T., Taylor B.V., Stewart G.J., Harbo H.F., Compston A., Hauser S.L., Hafler D.A., Zipp F., De Jager P., Sawcer S., Oksenberg J.R., Baranzini S.E., International Multiple Sclerosis Genetics Consortium (2019)
      Genome-wide association studies (GWAS) have identified more than 50,000 unique associations with common human traits. While this represents a substantial step forward, establishing the biology underlying these associations ...

    • Transcriptome Analysis Identifies Immune Markers Related to Visceral Leishmaniasis Establishment in the Experimental Model of BALB/c Mice 

      Agallou M., Athanasiou E., Kammona O., Tastsoglou S., Hatzigeorgiou A.G., Kiparissides C., Karagouni E. (2019)
      Visceral leishmaniasis (VL) caused by Leishmania donovani and L. infantum is a potentially fatal disease. To date there are no registered vaccines for disease prevention despite the fact that several vaccines are in ...