• Cellular communication network 2 (connective tissue growth factor) aggravates acute DNA damage and subsequent DNA damage response-senescence-fibrosis following kidney ischemia reperfusion injury 

      Valentijn F.A., Knoppert S.N., Marquez-Exposito L., Rodrigues-Diez R.R., Pissas G., Tang J., Tejedor-Santamaria L., Broekhuizen R., Samarakoon R., Eleftheriadis T., Goldschmeding R., Nguyen T.Q., Ruiz-Ortega M., Falke L.L. (2022)
      Chronic allograft dysfunction with progressive fibrosis of unknown cause remains a major issue after kidney transplantation, characterized by ischemia-reperfusion injury (IRI). One hypothesis to account for this is that ...
    • Clinical effect of accessory renal artery coverage after endovascular repair of aneurysms in abdominal and thoracoabdominal aorta 

      Spanos K., Nana P., Brotis A.G., Kouvelos G., Behrendt C.-A., Tsilimparis N., Kölbel T., Matsagkas M., Giannoukas A. (2021)
      Background: The aim of our systematic review and meta-analysis was to assess the effect of accessory renal artery (ARA) coverage on renal function in terms of acute kidney injury (AKI), renal infarction, chronic renal ...
    • The effect of endovascular aneurysm repair on renal function in patients treated for abdominal aortic aneurysm 

      Nana P., Kouvelos G., Brotis A., Spanos K., Giannoukas A., Matsagkas M. (2019)
      Aim: The effect of endovascular aneurysm repair in patients treated for abdominal aortic aneurysm has not been clearly defined. The objective of the present article was to provide a contemporary literature review and perform ...
    • EPIdemiology of Surgery-Associated Acute Kidney Injury (EPIS-AKI): Study protocol for a multicentre, observational trial 

      Weiss R., Saadat-Gilani K., Kerschke L., Wempe C., Meersch M., Zarbock A., Makhloufi H., Cherak A., Ghanem L.L., Gouaglia Z., Guadouri D.N., Hama F.N., Kara M., Saadi O., Sakhraoui R., Bourou F., Cherifi A., Sadaoui R.G., Ouyahia A., Ouahab I., Bouaoud S., Abdoun M., Tidjane A., Tabeti B., Boudjenan-Serradj N., Rivera C.J.P., Cabrer P., Corso J., García J.P., Idarraga S., Montoya C., Figueroa R., Aldana E., Torrado M.A., Peng K., Ma Z.-M., Yang Y.-F., Zhu Y.-J., Sklienka P., Frelich M., Jarkulis V., Sevcik P., Vodicka V., Elbahnasawy M.G., Elsalhawy S., Motawea S., Othman Z., Sahma M., Nafea A.M., Ahmed N., Attia D.A., Emara M.M., Bonna M.M., Gabr M.A., Tarbay A.I., Abdehaleem I.A., Mohamed E.E., Eldeeb A.M., Abbas A.M., Magdy J.A., Hamed Z.H., Osman H.M.E., Abbas M.S., Joannes-Boyau O., Barraud N., Berthelot C., Camus T., Dahmi A., Defaye M., Derville S., El-Boustani Y., Deloge E., Jacob H., Monziols S., Priem F., Robin J.-J., Legros V., Floch T., Muccio S., Geneve C., Legouge M.L., Mauny S.T., Mfam W., Pascot L., Aveline C., Chartier M., Duteurtre B., Gautier J.F., Cousin A.L., Vautier P., Nadaud J., Begel N., Chekirine C.-A., Derlon V., Grein E., Lehair M.-A., Magazzeni L., Magazzeni P., Potter C., Roth C., Voivret F., Rimmelé T., Cerro V., Suria S., Elmawieh J., Stoclin A., Cirenei C., Andrieu G., Couloumy S., Falcone J., Fajardy M., Gagneuil A., Girardet E., Mazereeuw A., Ponsonnard S., Egreteau P.-Y., Bertel M., Bocher S., Carn V., Guen L.L., Loup G.L., Lefevre M., Ichai C., Diop A., Jean-Michel V., Devlieger S., Duthoit J., El Kadiri M., Léger M., Cassisa V., Lasocki S., Masson C., Rineau E., Verrier P., Coquerel A., Montravers P., Atchade E., Rochon C.-E., Delerue C., Quentin V., Latry V., Queixalos N., Cottenceau V., Braun T., Bouzoubaa S., Christ B., Geiger A., Gomille J., Kieffer V., Mangeant S., Prochilo C., Schmitt C., Skwirba S., Grand H., Boury F., Mayeur N., Pasquie M., Garçon P., Bruckert V., Arnould V., Bonciu M., Chapelle T., Facchino L., Fagot-Gandet F., Iachim A., Mannu E., Perus O., Plattier R., Rozier R., Pradel G., Boudinaud M., Hausermann M.-H., Nguyen M.H., Ramorasata A., Barreau A., Boivin A.-H., Ravry C., Mottard N., Beuvelot J., Bossion F.P., Desebbe O., Zarbock A., Dörr C., von Groote T.C., Küllmar M., Massoth C., Meersch M., Saadat-Gilani K., Weiss R., Wempe C., Ziemann S., Grüßer L., Kowark A., Wittig P., Brandenburger T., Dimski T., Döhmen N., Huthmann L., Kaierle D., Pelletier C., Schleß M., Hohn A., Cleophas S., Haunhorst S., Jansen M., Schmitt A., Soisch J., Sturm K., Rosenberger P., Bendig A., Flohr L., Häberle H., Hofmann P., Kuhle J., Leser N.M., Pfister K., Prohaska S., Sennholz F., Stetz L., Weber K., Stehr S., Klaus S., Sadlo M., Boschin M., Sengelhoff C., Göbel U.M., Haaker J.G., Göttker C.-K., Gründel M., Heringlake M., Baumgärtel R., Berggren A., Gülzow M., Muras L., Paarmann H., Thal S., Bentley A., El-Masri D., Sebastiani A., Arnaoutoglou E., Ntalouka M., Stratigopoulou P., Analytis A., Mavrommatis E., Tzimas P., Karakosta A., Pantazi D., Dimakopoulou A., Dimitropoulou K., Ioannidis O., Jalaawiy H., Anwar A., Hashim H.T., Aldawoody H.I.R., Cortegiani A., Catalisano G., Ingoglia G., Ippolito M., De Rosa S., Cattin L., Bianchin A., Barone M., Paternoster G., Cutuli S.L., Russo A., Sollazzi L., Cascarano L., Antonelli M., Aceto P., Romanò B., Spadaro S., Tripodi V.F., Rossi M., Scappatura R., Vadalà M.C., Fiume D., Strano M.T., Oddo G., Santorsola C., Hussain B.A., Alnaser A.R., Ghassan A.H., Hasanein K., Theab M., Shin S., Jung S., Lee K., Jung S.M., Baek J., Elhadi M.K., Aldressi W.W.O., Abuzeid I., Albaraesi M., Aldressi S., Khalel W., Abdulwahed E., Abujrad A.A.A., Almaghrabi A., Alteleeb M., Alshareea E.A.A., Biala M.I., Deeknah A., Gheddim D.A., Ghmagh R., Ikhrays N.S.A.A., Sinan M., Soula E., Bahroun S.G., Derwish K., Mohamed A.M., Younes E.S., Al Islam Benjouira R., Aliwa M., Altashani N.A., Alteb M.O., Msherghi A., Alagelli F., Albarouni S., Albishti A., Aljamal S., Alsori M., Ekhuja T., Elzwai S., Ghula M., Mustafa T., Tuwaib A., Zriba H., Agilla H.M., Rafanomezantsoa T.A., Podesta A.M.C., Bonnici D.M., Pirotta T., López G.A.G., Mijovska M.M., Davitkovska T., Gavrilovska A., Lukikj S., Vesova M., Zafirova D., Amro S., Hajjaj B.N.F., Alkhazendar M., Barakat Y., Elejla S.A., Elhissi A., Khader A., Salem A., de Freitas Regufe R., de Oliveira Eloy A.F., Perdigão L.M.N.C., Grigoriev E., Ivkin A., Kornelyuk R., Yaroustovsky M., Abramyan M., Komardina E., Lesteva N., Aybazova M., Kumykova E., Lesina S., Rybakov G., Shestov A., Barmou A.A.A., Ahmed B.L.A., Eliyas A.M., Emadeldin Y., Kaserer A., Castellucci C., Rössler J., Akbas S., Petrun A.M., Gregorcic I., Sok V., Cicak R., Bárcena E., Guisado A., Wi I., Melchor J.R., Becerra-Bolaños Á., Cabrera-Doreste S., Domínguez-Arbelo A., Delgado-Alonso M.C., Muiño-Palomar V., Rodríguez-Pérez A., Estévez J.M., Munoz M.B.C., Matas J.M., Palao S.P., Quirós M.D.M., Teslev A.C., Argilaga M., Campos M., Bainac A., Batalla A., Alvarez M.G., Giné M., Herránz G., Hinojal I., Ejea M.L., de la Rosa Ruiz N., Abasolo M.G., Acuna C.R.H., Zaranton I.I., Mendigurenmurua A., Sanz M.J.M., de la Fuente E.O., Vaquero M.P.P., Iglesias A.S., Mieres A.U., Urrestizala A.U., Ferreira L., Lobato F., Sevilla M.A., Erazo A., Miró P., Sabaté S., Vernetta D., Perez A.A., Pagola M.A., Paulis B.C., del Val Peciña E., Odriozola A.G., Aizpurua A.L., Piquer O.P., Garcia P.P., Rezola P.O., Lopez A.O., de la Calle Gil I., Casado R.N., Adamove P., Domenge R.B., Blasco F.M.B., Villamizar A.A.R., Llaneras M.A.P., García-Sánchez J.I., Téllez L.F., Zamorano S.G., Herreros N.G., Esteve A.R., Rodríguez P.M., Trigo I.G., Alcaraz A., Jiménez A.L., Rubio I., García N., Callejas R., Toha A.M.C., Claros E., Cobeta P., Crespo P., Dorado T., Elías E., Felices J., Gil D., Gómez M., Mané N., Martín M., Martínez A., Pereira L., Samaranch A.B.N., Serrano A., Tiscar C., VillaHoz J., Menéndez P.G., Cardona E., Conesa A., Estepa V., Galán P., Espí L.L., Aldeán Y.L., Manrique S., Ariza V.M., Villa L.V., Suliman E.S.M.A., Hamid H., Ibrahim A.M., Saeed M.M., Mukadder O.S., Altun D., Canbolat N., Dinçer M.B., Seyhan T.Ö., Yildirim S.A., Iyigün M., Yapici D., Özdemir L., Sagun A., Boztug N., Cetintas Y., Dinc B., Gündüz E., Ünlügenç H., Tunay D.L., Karakaya D., Dost B., Komurcu O., Akcil E.F., Dilmen Ö.K., Tunali Y., Ok G., Alsina E.T., Hakli Ö., Polat C., Turgut N., Kizilcik N., Köner Ö., Sen Ö., Aydin N., Basaran B., Bingul E.S., Gürkan Y., Darcin K., Ugur S., Saracoglu K.T., Demir A., Aysegül Ö., Balci E., Girgin B., Guler A., Karadeniz Ü., Özaslan N., Hülya Y.Ö., Ozcan N., Postaci A., Sahap M., Salman N., Sagir Ö., Atik B., Bicakcioglu M., Demir H.F., Fatih U., Kocaoglu N., Toprak H.I., Aslan D.D., Colak Y.Z., Ozcan M.S., Yilmaz M., Karaca U., Sahin S.H., Karka Ö.E., Senoglu G.D., Karadag S.E., Alkis N., Baytas V., Akdogan A., Besir A., Erturk E., Kutanis D., Saylan S., Tugcugil E., Ayvat P., Günaydin B., Büyükgebiz B.M., Boran O.F., Calisir F., Orak Y., Balkan B.K., Büyükcoban S., Gökel E., Günenc S.F., Özbilgin S., Göre S., Akesen S., Cansabuncu S., Momot N., Panchenko A., Pittet J.-F., Rutledge K., the EPIS-AKI Investigators (2021)
      Introduction More than 300 million surgical procedures are performed each year. Acute kidney injury (AKI) is a common complication after major surgery and is associated with adverse short-term and long-term outcomes. ...
    • Lack of synergistic nephrotoxicity between vancomycin and piperacillin/tazobactam in a rat model and a confirmatory cellular model 

      Pais G.M., Liu J., Avedissian S.N., Hiner D., Xanthos T., Chalkias A., D'Aloja E., Locci E., Gilchrist A., Prozialeck W.C., Rhodes N.J., Lodise T.P., Fitzgerald J.C., Downes K.J., Zuppa A.F., Scheetz M.H. (2020)
      Vancomycin and piperacillin/tazobactam are reported in clinical studies to increase acute kidney injury (AKI). However, no clinical study has demonstrated synergistic toxicity, only that serum creatinine increases. To ...
    • Nephrotoxicity issues of organophosphates 

      Georgiadis G., Mavridis C., Belantis C., Zisis I.E., Skamagkas I., Fragkiadoulaki I., Heretis I., Tzortzis V., Psathakis K., Tsatsakis A., Mamoulakis C. (2018)
      Organophosphates are a large class of chemicals, initially invented in 1850 and since then they have been applied in numerous aspects of science to serve our purposes. Their mechanism of action in living organisms involves ...
    • Oxidative Stress and Acute Kidney Injury in Critical Illness: Pathophysiologic Mechanisms - Biomarkers - Interventions, and Future Perspectives 

      Pavlakou P., Liakopoulos V., Eleftheriadis T., Mitsis M., Dounousi E. (2017)
      Acute kidney injury (AKI) is a multifactorial entity that occurs in a variety of clinical settings. Although AKI is not a usual reason for intensive care unit (ICU) admission, it often complicates critically ill patients' ...
    • Renal function impairment in patients undergoing elective EVAR vs. Elective open repair during follow up period: A systematic review of the literature 

      Spanos K., Karathanos C., Athanasoulas A., Saleptsis V., Vasilopoulos I., Xhepa S., Matsagkas M., Giannoukas A.D. (2017)
      Background: Endovascular (EVAR) or open surgical (OSR) repair are current treatment options for abdominal aortic aneurysm (AAA). Objective: To produce a systematic review comparing the impact of these 2 treatment options ...
    • Renal outcomes in valve-in-valve transcatheter versus redo surgical aortic valve replacement: A systematic review and meta-analysis 

      Arjomandi Rad A., Naruka V., Vardanyan R., Salmasi M.Y., Tasoudis P.T., Kendall S., Casula R., Athanasiou T. (2022)
      Introduction: Postoperative acute kidney injury (AKI) and the requirement for renal replacement therapy (RRT) remain common and significant complications of both transcatheter valve-in-valve aortic valve replacement ...
    • The role of indoleamine 2,3-dioxygenase in renal tubular epithelial cells senescence under anoxia or reoxygenation 

      Eleftheriadis T., Pissas G., Filippidis G., Liakopoulos V., Stefanidis I. (2021)
      Ischemia-reperfusion injury is the commonest form of acute kidney injury (AKI). Tubular epithelial cell senescence contributes to incomplete recovery from AKI and predisposes to subsequent chronic kidney disease. In cultures ...
    • Soluble urokinase receptor (SuPAR) in COVID-19-Related AKI 

      Azam T.U., Shadid H.R., Blakely P., O'Hayer P., Berlin H., Pan M., Zhao P., Zhao L., Pennathur S., Pop-Busui R., Altintas I., Tingleff J., Stauning M.A., Andersen O., Adami M.-E., Solomonidi N., Tsilika M., Tober-Lau P., Arnaoutoglou E., Keitel V., Tacke F., Chalkias A., Loosen S.H., Giamarellos-Bourboulis E.J., Eugen-Olsen J., Reiser J., Hayek S.S., Hayek S.S., Blakely P., Berlin H., Azam T.U., Shadid H., Pan M., O'Hayer P., Meloche C., Feroze R., Padalia K.J., Anderson E., Perry D., Bitar A., Kaakati R., Zhao L., Zhao P., Eugen-Olsen J., Altintas I., Tingleff J., Stauning M., Houlind M.B., Lindstrøm M.B., Andersen O., Gamst-Jensen H., Rasmussen L.J.H., Rasmussen C., Nehlin J.O., Kallemose T., Parvaiz I., Adami M.-E., Solomonidi N., Tsilika M., Saridaki M., Lekakis V., Loosen S., Luedde T., Keitel V., Arnaoutoglou E., Pantazopoulos I., Laou E., Kolonia K., Skoulakis A., Tacke F., Tober-Lau P., Mohr R., Kurth F., Sander L.E., Jochum C., International Study of Inflammation in COVID-19 (2020)
      Background AKI commonly occurs in patients with coronavirus disease 2019 (COVID-19). Its pathogenesis is poorly understood. The urokinase receptor system is a key regulator of the intersection between inflammation, immunity, ...
    • Statin loading in cardiovascular surgery: Never too early to treat 

      Katsiki N., Triposkiadis F., Giannoukas A.D., Mikhailidis D.P. (2018)
      Purpose of review The effects of statin loading before, during or after vascular interventions on cardiovascular and renal outcomes are discussed. Furthermore, the selection of optimal statin type and dose, according to ...
    • Urinary Metabolomics From a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury 

      Locci E., Liu J., Pais G.M., Chighine A., Kahnamoei D.A., Xanthos T., Chalkias A., Lee A., Hauser A.R., Chang J., Rhodes N.J., d'Aloja E., Scheetz M.H. (2022)
      Background: Polymyxin B treatment is limited by kidney injury. This study sought to identify Polymyxin B-related urinary metabolomic profile modifications for early detection of polymyxin-associated nephrotoxicity. Methods: ...