Πλοήγηση ανά Συγγραφέα "Smyk, D. S."
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Asialoglycoprotein receptor (ASGPR) as target autoantigen in liver autoimmunity: Lost and found
Rigopoulou, E. I.; Roggenbuck, D.; Smyk, D. S.; Liaskos, C.; Mytilinaiou, M. G.; Feist, E.; Conrad, K.; Bogdanos, D. P. (2012)Asialoglycoprotein receptor (ASGPR) has attracted the attention of liver immunologists for many years. This liver-specific lectin was found to be a major B and T cell autoantigenic target in patients with autoimmune liver ... -
Autoantibodies in autoimmune pancreatitis
Smyk, D. S.; Rigopoulou, E. I.; Koutsoumpas, A. L.; Kriese, S.; Burroughs, A. K.; Bogdanos, D. P. (2012)Autoimmune pancreatitis (AIP) was first used to describe cases of pancreatitis with narrowing of the pancreatic duct, enlargement of the pancreas, hyper - globulinaemia, and antinuclear antibody (ANA) positivity serologically. ... -
Bioinformatic and immunological analysis reveals lack of support for measles virus related mimicry in Crohn's disease
Polymeros, D.; Tsiamoulos, Z. P.; Koutsoumpas, A. L.; Smyk, D. S.; Mytilinaiou, M. G.; Triantafyllou, K.; Bogdanos, D. P.; Ladas, S. D. (2014)Background: A link between measles virus and Crohn's disease (CD) has been postulated. We assessed through bioinformatic and immunological approaches whether measles is implicated in CD induction, through molecular mimicry. ... -
Diagnostic and clinical significance of Crohn's disease-specific anti-MZGP2 pancreatic antibodies by a novel ELISA
Pavlidis, P.; Shums, Z.; Koutsoumpas, A. L.; Milo, J.; Papp, M.; Umemura, T.; Lakatos, P. L.; Smyk, D. S.; Bogdanos, D. P.; Forbes, A.; Norman, G. L. (2015)Background: We developed a new IgA and IgG anti-MZGP2 antibody ELISAs based on recombinant isoform-4 of human zymogen granule protein-2 (GP2), which is the major autoantigen of Crohn's disease (CrD)-specific pancreatic ... -
Diagnostic value, clinical utility and pathogenic significance of reactivity to the molecular targets of Crohn's disease specific-pancreatic autoantibodies
Bogdanos, D. P.; Rigopoulou, E. I.; Smyk, D. S.; Roggenbuck, D.; Reinhold, D.; Forbes, A.; Laass, M. W.; Conrad, K. (2011)Pancreatic autoantibodies (PAB) giving characteristic staining patterns of the exocrine pancreas by indirect immunoflourescence appear to be specific markers of Crohn's disease (CrD), being present in approximarely 30% of ... -
Epstein-barr virus as a trigger of autoimmune liver diseases
Rigopoulou, E. I.; Smyk, D. S.; Matthews, C. E.; Billinis, C.; Burroughs, A. K.; Lenzi, M.; Bogdanos, D. P. (2012)The pathogenesis of autoimmune diseases includes a combination of genetic factors and environmental exposures including infectious agents. Infectious triggers are commonly indicated as being involved in the induction of ... -
Familial primary biliary cirrhosis: Like mother, like daughter?
Smyk, D. S.; Rigopoulou, E. I.; Pares, A.; Mytilinaiou, M. G.; Invernizzi, P.; Bogdanos, D. P. (2012)The reasons underlying why autoimmune diseases overwhelmingly affect women more than men are not clear. Nor are the reasons why autoimmune disease is more prevalent in families. This review uses primary biliary cirrhosis ... -
Helicobacter pylori and autoimmune disease: Cause or bystander
Smyk, D. S.; Koutsoumpas, A. L.; Mytilinaiou, M. G.; Rigopoulou, E. I.; Sakkas, L. I.; Bogdanos, D. P. (2014)Helicobacter pylori (H. pylori) is the main cause of chronic gastritis and a major risk factor for gastric cancer. This pathogen has also been considered a potential trigger of gastric autoimmunity, and in particular of ... -
Ileal InflammationMay Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn's Disease
Pavlidis, P.; Romanidou, O.; Roggenbuck, D.; Mytilinaiou, M. G.; Al-Sulttan, F.; Liaskos, C.; Smyk, D. S.; Koutsoumpas, A. L.; Rigopoulou, E. I.; Conrad, K.; Forbes, A.; Bogdanos, D. P. (2012)Why zymogen glycoprotein 2 (GP2), the Crohn's disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 ... -
Immunopathogenesis of primary biliary cirrhosis: an old wives' tale
Smyk, D. S.; Rigopoulou, E. I.; Lleo, A.; Abeles, R. D.; Mavropoulos, A.; Billinis, C.; Invernizzi, P.; Bogdanos, D. P. (2011)Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the autoimmune destruction of the small intrahepatic bile ducts. The disease has an unpredictable clinical course, but may progress to fibrosis ... -
Infectome: A platform to trace infectious triggers of autoimmunity
Bogdanos, D. P.; Smyk, D. S.; Invernizzi, P.; Rigopoulou, E. I.; Blank, M.; Pouria, S.; Shoenfeld, Y. (2013)The "exposome" is a term recently used to describe all environmental factors, both exogenous and endogenous, which we are exposed to in a lifetime. It represents an important tool in the study of autoimmunity, complementing ... -
Infectomics and autoinfectomics: a tool to study infectious-induced autoimmunity
Bogdanos, D. P.; Smyk, D. S.; Rigopoulou, E. I.; Sakkas, L. I.; Shoenfeld, Y. (2015)The exposome represents all exogenous and endogenous environmental exposures that begin at preconception and carry on throughout life, while the microbiome reflects the microbial component of the exposome. We recently ... -
New sensitive technique for the detection of anti-smooth muscle antibodies in autoimmune hepatitis
Liaskos, C.; Mytilinaiou, M. G.; Grammatikopoulos, A.; Smyk, D. S.; Orfanidou, T.; Mavropoulos, A.; Norman, G. L.; Rigopoulou, E. I.; Mieli-Vergani, G.; Bogdanos, D. P.; Vergani, D. (2012) -
P38 MAPK signaling in pemphigus: Implications for skin autoimmunity
Mavropoulos, A.; Orfanidou, T.; Liaskos, C.; Smyk, D. S.; Spyrou, V.; Sakkas, L. I.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)p38 mitogen activated protein kinase (p38 MAPK) signaling plays a major role in the modulation of immune-mediated inflammatory responses and therefore has been linked with several autoimmune diseases. The extent of the ... -
p38 mitogen-activated protein kinase (p38 MAPK)-mediated autoimmunity: Lessons to learn from ANCA vasculitis and pemphigus vulgaris
Mavropoulos, A.; Orfanidou, T.; Liaskos, C.; Smyk, D. S.; Billinis, C.; Blank, M.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)Evidence is beginning to accumulate that p38 mitogen activated protein kinase (p38 MAPK) signaling pathway plays an important role in the regulation of cellular and humoral autoimmune responses. The exact mechanisms and ... -
Potential Roles for Infectious Agents in the Pathophysiology of Primary Biliary Cirrhosis: What's New?
Smyk, D. S.; Rigopoulou, E. I.; Bogdanos, D. P. (2013)Primary biliary cirrhosis (PBC) is a progressive cholestatic liver disease serologically characterized by the presence of high-titer antimitochondrial antibodies and, histologically by chronic nonsuppurative cholangitis ... -
Primary biliary cirrhosis associated with systemic sclerosis: Diagnostic and clinical challenges
Rigamonti, C.; Bogdanos, D. P.; Mytilinaiou, M. G.; Smyk, D. S.; Rigopoulou, E. I.; Burroughs, A. K. (2011)Patients with primary biliary cirrhosis (PBC) often have concurrent limited systemic sclerosis (SSc). Conversely, up to one-fourth of SSc patients are positive for PBC-specific antimitochondrial antibodies (AMA). The ... -
Sex Differences Associated with Primary Biliary Cirrhosis
Smyk, D. S.; Rigopoulou, E. I.; Pares, A.; Billinis, C.; Burroughs, A. K.; Muratori, L.; Invernizzi, P.; Bogdanos, D. P. (2012)Primary biliary cirrhosis (PBC) is a cholestatic liver disease of autoimmune origin, characterised by the destruction of small intrahepatic bile ducts. The disease has an unpredictable clinical course but may progress to ... -
Smoking as a risk factor for autoimmune liver disease: What we can learn from primary biliary cirrhosis
Smyk, D. S.; Rigopoulou, E. I.; Muratori, L.; Burroughs, A. K.; Bogdanos, D. P. (2012)Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the immune-mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. The disease is characterised by circulating ... -
Towards systemic sclerosis and away from primary biliary cirrhosis: The case of PTPN22
Smyk, D. S.; Mytilinaiou, M. G.; Milkiewicz, P.; Rigopoulou, E. I.; Invernizzi, P.; Bogdanos, D. P. (2012)Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by immune-mediated destruction of the small and medium size intrahepatic bile ducts. PBC patients often have concomitant autoimmune ...