Parcourir par auteur "Platsoucas, C. D."
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Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment
Sakkas, L. I.; Bogdanos, D. P.; Katsiari, C.; Platsoucas, C. D. (2014)Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein/peptide autoantibodies (ACPAs). Citrulline derives from arginine by peptidyl ... -
Decreased Expression of the CD3ζ Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis
Sakkas, L. I.; Koussidis, G.; Avgerinos, E.; Gaughan, J.; Platsoucas, C. D. (2004)Osteoarthritis (OA) is a heterogeneous disease which rheumatologists consider to be noninflammatory. However, recent studies suggest that, at least in certain patients, OA is an inflammatory disease and that patients often ... -
Is systemic sclerosis an antigen-driven T cell disease?
Sakkas, L. I.; Platsoucas, C. D. (2004) -
Mechanisms of Disease: the role of immune cells in the pathogenesis of systemic sclerosis
Sakkas, L. I.; Chikanza, I. C.; Platsoucas, C. D. (2006)Systemic sclerosis is characterized by extensive fibrosis, microvascular stenosis and autoantibody production. All three characteristics can be accounted for by activation of cells of the immune system. Activation of T ... -
The role of T cells in the pathogenesis of osteoarthritis
Sakkas, L. I.; Platsoucas, C. D. (2007) -
Role of T cells in the pathogenesis of osteoarthritis
Sakkas, L. I.; Platsoucas, C. D. (2002) -
Systemic sclerosis: From pathogenesis towards targeted immunotherapies
Sakkas, L. I.; Chikanza, I. C.; Platsoucas, C. D. (2012)Systemic sclerosis (SSc), a chronic disease with widespread collagen deposition, has three pathogenetic facets: immune activation, microvasculopathy and fibroblast activation. Immune activation and microvasculopathy occur ... -
T-cells and B-cells in systemic sclerosis
Sakkas, L. I.; Platsoucas, C. D. (2010)Systemic sclerosis (SSc) is characterized by activation of fibroblasts with extensive deposition of collagen, by small vessel vasculopathy with fibrointimal proliferation, and activation of the immune system, with hyper-γ- ...