• A bioequivalence study of Levothyroxine tablets versus an oral Levothyroxine solution in healthy volunteers 

      Yannovits, N.; Zintzaras, E.; Pouli, A.; Koukoulis, G.; Lyberi, S.; Savari, E.; Potamianos, S.; Triposkiadis, F.; Stefanidis, I.; Zartaloudis, E.; Benakis, A. (2006)
      Probably for genetic reasons a substantial part of the Greek population requires Levothyroxine treatment. Since commercially available Levothyroxine was first marketed, the manufacture and storage of the drug in tablet ...
    • Caffeine metabolism in liver cirrhosis 

      Begas, E.; Asprodini, E. K.; Papakosta, S.; Maglaras, L.; Benakis, A.; Dalekos, G. (2005)
      Caffeine is metabolized primarily by CYP1A2. Several methods have been developed for the in vivo assessment of CYP1A2 activity using caffeine as a probe drug (2). These methods include the determination of caffeine clearance ...
    • Determination of N-acetylation phenotyping in a Greek population using caffeine as a metabolic probe 

      Asprodini, E. K.; Zifa, E.; Papageorgiou, I.; Benakis, A. (1998)
      Studies of isoniazid, the well known antituberculosis drug, have revealed that N-acetylation polymorphism, is of great clinical importance. In humans, N-acetylation is one of the most important pathways in the inactivation ...
    • Skeletal muscle relaxants in anaesthesiology 

      Benakis, A.; Plessas, C. T.; Plessas, S. T. (1999)
      During the 16th century, European explorers found that the Indians along the Amazon and Orinoco Rivers were using an arrow poison, named curare, that produced death by skeletal paralysis. Curare is one of several different ...