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Πλοήγηση ανά Θέμα "MicroRNAs"

Αποτελέσματα 1-20 από 68

    • Association of miR-144 levels in the peripheral blood with COVID-19 severity and mortality 

      Madè A., Greco S., Vausort M., Miliotis M., Schordan E., Baksi S., Zhang L., Baryshnikova E., Ranucci M., Cardani R., Fagherazzi G., Ollert M., Tastsoglou S., Vatsellas G., Hatzigeorgiou A., Firat H., Devaux Y., Martelli F. (2022)
      Coronavirus disease-2019 (COVID-19) can be asymptomatic or lead to a wide symptom spectrum, including multi-organ damage and death. Here, we explored the potential of microRNAs in delineating patient condition and predicting ...

    • Bioinformatic Analysis of the BCL-xL/BCL2L1 Interactome in Patients with Pancreatic Cancer 

      Magouliotis D.E., Karamolegkou A.P., Zotos P.-A., Tatsios E., Samara A.A., Alexopoulou D., Koutsougianni F., Sakellaridis N., Zacharoulis D., Dimas K. (2022)
      Objectives: The aim of the present study was to analyze the differential gene expression of BCL-xL/BCL2L and the associated genetic, molecular, and biologic functions in pancreatic ductal adenocarcinoma (PDAC) by employing ...

    • BUFET: Boosting the unbiased miRNA functional enrichment analysis using bitsets 

      Zagganas K., Vergoulis T., Paraskevopoulou M.D., Vlachos I.S., Skiadopoulos S., Dalamagas T. (2017)
      Background: A group of miRNAs can regulate a biological process by targeting genes involved in the process. The unbiased miRNA functional enrichment analysis is the most precise in silico approach to predict the biological ...

    • Characterizing miRNA–lncRNA Interplay 

      Karagkouni D., Karavangeli A., Paraskevopoulou M.D., Hatzigeorgiou A.G. (2021)
      Long noncoding RNAs (lncRNAs) are noncoding transcripts, usually longer than 200 nt, that constitute one of the largest and significantly heterogeneous RNA families. The annotation of lncRNAs and the characterization of ...

    • DIANA-LncBase v2: Indexing microRNA targets on non-coding transcripts 

      Paraskevopoulou M.D., Vlachos I.S., Karagkouni D., Georgakilas G., Kanellos I., Vergoulis T., Zagganas K., Tsanakas P., Floros E., Dalamagas T., Hatzigeorgiou A.G. (2016)
      MicroRNAs (miRNAs) are short non-coding RNAs (ncRNAs) that act as post-transcriptional regulators of coding gene expression. Long non-coding RNAs (lncRNAs) have been recently reported to interact with miRNAs. The sponge-like ...

    • DIANA-LncBase v3: Indexing experimentally supported miRNA targets on non-coding transcripts 

      Karagkouni D., Paraskevopoulou M.D., Tastsoglou S., Skoufos G., Karavangeli A., Pierros V., Zacharopoulou E., Hatzigeorgiou A.G. (2020)
      DIANA-LncBase v3.0 (www.microrna.gr/LncBase) is a reference repository with experimentally supported miRNA targets on non-coding transcripts. Its third version provides approximately half a million entries, corresponding ...

    • Diana-map: Analyzing mirna from raw ngs data to quantification 

      Alexiou A., Zisis D., Kavakiotis I., Miliotis M., Koussounadis A., Karagkouni D., Hatzigeorgiou A.G. (2021)
      microRNAs (miRNAs) are small non-coding RNAs (~22 nts) that are considered central post-transcriptional regulators of gene expression and key components in many pathological conditions. Next-Generation Sequencing (NGS) ...

    • DIANA-mirExTra v2.0: Uncovering microRNAs and transcription factors with crucial roles in NGS expression data 

      Vlachos I.S., Vergoulis T., Paraskevopoulou M.D., Lykokanellos F., Georgakilas G., Georgiou P., Chatzopoulos S., Karagkouni D., Christodoulou F., Dalamagas T., Hatzigeorgiou A.G. (2016)
      Differential expression analysis (DEA) is one of the main instruments utilized for revealing molecular mechanisms in pathological and physiological conditions. DIANA-mirExTra v2.0 (http://www.microrna. gr/mirextrav2) ...

    • DIANA-miRGen v3.0: Accurate characterization of microRNA promoters and their regulators 

      Georgakilas G., Vlachos I.S., Zagganas K., Vergoulis T., Paraskevopoulou M.D., Kanellos I., Tsanakas P., Dellis D., Fevgas A., Dalamagas T., Hatzigeorgiou A.G. (2016)
      MicroRNAs (miRNAs) are small non-coding RNAs that actively fine-tune gene expression. The accurate characterization of the mechanisms underlying miRNA transcription regulation will further expand our knowledge regarding ...

    • DIANA-miRGen v4: Indexing promoters and regulators for more than 1500 microRNAs 

      Perdikopanis N., Georgakilas G.K., Grigoriadis D., Pierros V., Kavakiotis I., Alexiou P., Hatzigeorgiou A. (2021)
      Deregulation of microRNA (miRNA) expression plays a critical role in the transition from a physiological to a pathological state. The accurate miRNA promoter identification in multiple cell types is a fundamental endeavor ...

    • DIANA-miTED: A microRNA tissue expression database 

      Kavakiotis I., Alexiou A., Tastsoglou S., Vlachos I.S., Hatzigeorgiou A.G. (2022)
      microRNAs (miRNAs) are short (∼23nt) single-stranded non-coding RNAs that act as potent post-transcriptional gene expression regulators. Information about miRNA expression and distribution across cell types and tissues is ...

    • DIANA-tarbase and DIANA suite tools: Studying experimentally supported microRNA targets 

      Paraskevopoulou M.D., Vlachos I.S., Hatzigeorgiou A.G. (2016)
      microRNAs (miRNAs) are short non-coding RNAs (~22 nts) present in animals, plants, and viruses. They are considered central post-transcriptional regulators of gene expression and are key components in a great number of ...

    • DIANA-TarBase v8: A decade-long collection of experimentally supported miRNA-gene interactions 

      Karagkouni D., Paraskevopoulou M.D., Chatzopoulos S., Vlachos I.S., Tastsoglou S., Kanellos I., Papadimitriou D., Kavakiotis I., Maniou S., Skoufos G., Vergoulis T., Dalamagas T., Hatzigeorgiou A.G. (2018)
      DIANA-TarBase v8 (http://www.microrna.gr/tarbase) is a reference database devoted to the indexing of experimentally supported microRNA (miRNA) targets. Its eighth version is the first database indexing >1 million entries, ...

    • DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis 

      Papathanasiou I., Trachana V., Mourmoura E., Tsezou A. (2019)
      Aims: Previous studies have demonstrated that transcriptional silencing of miRNAs due to DNA hypermethylation is associated with different pathologies. It has also been reported that abnormal expression of miR-140-5p and ...

    • Enhanced expression of miR-21 and miR-150 is a feature of anti-mitochondrial antibody-negative primary biliary cholangitis 

      Wasik U., Kempinska-Podhorodecka A., Bogdanos D.P., Milkiewicz P., Milkiewicz M. (2020)
      Background & Aims: Anti-mitochondrial-autoantibodies (AMA) remain a hallmark of Primary Biliary Cholangitis (PBC) however approximately 10% of patients test negative for these antibodies. They do not differ in terms of ...

    • Functional analysis of miRNAs using the DIANA tools online suite 

      Vlachos I.S., Hatzigeorgiou A.G. (2017)
      microRNAs (miRNAs) are central regulators of gene expression. They are actively studied for their involvement in numerous physiological and pathological conditions but also as diagnostic biomarkers or promising therapeutic ...

    • Genome-wide association study identifies candidate markers related to lincRNAs associated with male infertility in the Greek population 

      Kyrgiafini M.-A., Markantoni M., Sarafidou T., Chatziparasidou A., Christoforidis N., Mamuris Z. (2020)
      Background: Male infertility is currently one of the most common problems faced by couples worldwide. We performed a GWAS on Greek population and gathered statistically significant SNPs in order to investigate whether they ...

    • Hypoxia-induced changes in plasma micro-RNAs correlate with pulmonary artery pressure at high altitude 

      Blissenbach B., Nakas C.T., Krönke M., Geiser T., Merz T.M., Pichler Hefti J. (2018)
      In vitro and animal studies revealed micro-RNAs (miRs) to be involved in modulation of hypoxia-induced pulmonary hypertension (HPH). However, knowledge of circulating miRs in humans in the context of HPH is very limited. ...

    • Identifying pri-miRNA transcription start sites 

      Georgakilas G., Perdikopanis N., Hatzigeorgiou A.G. (2018)
      MicroRNAs (miRNAs) are small non-coding RNAs that can regulate gene expression playing vital role in nearly all biological pathways. Even though miRNAs have been intensely studied for more than two decades, information ...

    • Impact of miR-SNP rs2910164 on miR-146a expression in osteoarthritic chondrocytes 

      Papathanasiou I., Mourmoura E., Balis C., Tsezou A. (2020)
      Purpose: MiR-146a acts as a negative inflammatory mediator in different diseases and has been implicated in osteoarthritis (OA) pathogenesis. In our study, we investigated the association between miR-SNP rs2910164 and OA ...