Πλοήγηση ανά Θέμα "transforming growth factor beta"
Αποτελέσματα 21-27 από 27
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Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes
(2017)Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics ... -
Smad4 and epithelial–mesenchymal transition proteins in colorectal carcinoma: an immunohistochemical study
(2018)Epithelial–mesenchymal transition (EMT) plays an important role in cancer metastasis. During EMT, tumor cells acquire the capacity to migrate and invade the stroma. Activation of the transforming growth factor-b (TGF-b) ... -
Systemic sclerosis: New evidence re-enforces the role of B cells
(2016)Systemic sclerosis (SSc) is characterized by widespread fibrosis, microangiopathy (vasospasms and stenosis), and formation of autoantibodies. T cell activation has been shown to contribute to fibrosis and microvasculopathy ... -
T-cells and B-cells in systemic sclerosis
(2010)Systemic sclerosis (SSc) is characterized by activation of fibroblasts with extensive deposition of collagen, by small vessel vasculopathy with fibrointimal proliferation, and activation of the immune system, with hyper-γ- ... -
TGF-β signaling is activated in patients with chronic HBV infection and repressed by SMAD7 overexpression after successful antiviral treatment
(2016)Objectives: Although animal studies demonstrated that Smad7 induction ameliorates TGF-β/SMAD-mediated fibrogenesis, its role in human hepatic diseases is rather obscure. Our study explored the activation status of TGF-β/activin ... -
Transcriptional regulatory networks of the proteasome in mammalian systems
(2022)The tight regulation of proteostasis is essential for physiological cellular function. Mammalian cells possess a network of mechanisms that ensure proteome integrity under normal or stress conditions. The proteasome, being ... -
Vascular endothelial growth factor (VEGF) in pleural effusions
(2007)Pleural effusion is a common clinical problem in everyday clinical practice. Vascular endothelial growth factor (VEGF) is a 34-45 kDa homodimeric glycoprotein, which is a potent mediator of angiogenesis and vascular ...