Πλοήγηση ανά Θέμα "pathogenesis"
Αποτελέσματα 21-40 από 112
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Cryoglobulinemia due to chronic viral hepatitis infections is not a major problem in clinical practice
(2001)Background: Essential mixed cryoglobulinemia (EMC) is a systemic disease frequently associated with chronic viral hepatitis. This study was conducted in order to assess the prevalence of EMC in patients with hepatitis B ... -
Cytokines and pathological sleep
(2008)Cytokines are proteins produced by leukocytes and other cells that function as intercellular mediators acting on several target tissues, resulting in multiple biologic actions. Over the last decade, medical research has ... -
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations
(2021)Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated ... -
Deciphering the genetics of primary angioedema with normal levels of C1 inhibitor
(2020)The genetic alteration underlying the great majority of primary angioedema with normal C1 inhibitor (nl-C1-INH-HAE) cases remains unknown. To search for variants associated with nl-C1-INH-HAE, we genotyped 133 unrelated ... -
DNA methylation regulates miR-140-5p and miR-146a expression in osteoarthritis
(2019)Aims: Previous studies have demonstrated that transcriptional silencing of miRNAs due to DNA hypermethylation is associated with different pathologies. It has also been reported that abnormal expression of miR-140-5p and ... -
Editorial for special issue “genetic basis and epidemiology of myopathies”
(2021)We are pleased to announce a Special Issue on the Genetic Basis and Epidemiology of Myopathies. This Special Issue is collecting papers pertaining to various lines of research focusing on the genetic basis and the epidemiology ... -
The effects of old, new and emerging medicines on metabolic aberrations in PCOS
(2012)Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age that is associated with significant adverse short- and long-term health consequences. Multiple metabolic aberrations, such as ... -
Effects of Redox Disturbances on Motility, Contractility and Muscle Tissue Pathogenesis
(2019)[No abstract available] -
Endothelin-1 plasma levels in hemodialysis treatment - The influence of type 2 diabetes
(2005)In patients on chronic hemodialysis the prevalence of atherosclerosis is increased and is by far the leading cause of morbidity and mortality. Endothelin-1, an endothelium-derived peptide with vasoconstrictive and mitogenic ... -
Evidence of deregulated cholesterol efflux in abdominal aortic aneurysm
(2016)Previous studies indicated that lipids may be associated with abdominal aortic aneurysm (AAA); however the molecular mechanism involved is unclear. Our study aimed to investigate the expression pattern of cholesterol efflux ... -
Experimental staphylococcal mastitis in bitches: Clinical, bacteriological, cytological, haematological and pathological features
(2007)The objectives of the work were to study the features of experimentally induced canine mastitis and to present hypotheses regarding the pathogenesis of the disease. The tight caudal abdominal mammary gland of six bitches ... -
Experimental study for evaluation of the efficacy of a biofilm-embedded bacteria-based vaccine against Staphylococcus chromogenes-associated mastitis in sheep
(2019)Although coagulase-negative staphylococci are the primary aetiological agents of subclinical mastitis in ewes, there is little information regarding vaccination against that infection. The objective of this study was to ... -
Factors affecting the frequency of ear canal and face infestation by Otodectes cynotis in the cat
(2001)Otodectes cynotis is responsible for at least 50% of canker cases diagnosed in cats world-wide. The role of Demodex cati in the pathogenesis of otitis and acne is still obscure. The aims of this study were to estimate the ... -
Fetomaternal alloimmunity as a cause of liver disease
(2011)Fetomaternal alloimmune disease has traditionally been associated with haematological disease such as fetomaternal alloimmune thrombocytopaenia and Rh haemolytic anaemia, but is now known to also be organ specific. Alloimmune ... -
FIP1L1-PDGFRA molecular analysis in the differential diagnosis of eosinophilia
(2009)Background: Primary eosinophlia associated with the FIP1L1-PDGFRA rearrangement represents a subset of chronic eosinophilic leukaemia (CEL) and affected patients are very sensitive to imatinib treatment. This study was ... -
Gene Expression Meta-Analysis of Potential Shared and Unique Pathways between Autoimmune Diseases under Anti-TNFα Therapy
(2022)While anti-TNFα has been established as an effective therapeutic approach for several autoimmune diseases, results from clinical trials have uncovered heterogeneous patients’ response to therapy. Here, we conducted a ... -
Genetic and molecular pathogenesis of Parkinson's disease
(2006)Parkinson's disease (PD), a common progressive degenerative disease of the central nervous system, affects about 1% of adults aged older than 60 years. PD is characterized by rigidity, tremor, postural instability and ... -
Genotype-Phenotype Relationships in Inheritable Idiopathic Pulmonary Fibrosis: A Greek National Cohort Study
(2022)Background: Monogenic and polygenic inheritances are evidenced for idiopathic pulmonary fibrosis (IPF). Pathogenic variations in surfactant protein-related genes, telomere-related genes (TRGs), and a single-nucleotide ... -
The Global Registry for Hereditary Angioedema due to C1-Inhibitor Deficiency
(2021)Hereditary angioedema (HAE) is a rare condition, mostly due to genetic deficiency of complement C1 inhibitor (C1-INH). The rarity of HAE impedes extensive data collection and assessment of the impact of certain factors ... -
The hard way from bench to bedside history lessons from the pathogenesis of idiopathic membranous nephropathy (mn)
(2020)Membranous nephropathy (MN) is one of the most common causes of adult nephrotic syndrome. Histopathology involves typical subepithelial immuncomplexes, with an obvious pathogenetic role. Today, the study of pathogenesis, ...