Πλοήγηση ανά Θέμα "MicroRNAs"
Αποτελέσματα 21-40 από 68
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In silico transcriptomic analysis of wound-healing-associated genes in malignant pleural mesothelioma
(2019)Background and objectives: Malignant pleural mesothelioma (MPM) is a devastating malignancy with poor prognosis. Reliable biomarkers for MPM diagnosis, monitoring, and prognosis are needed. The aim of this study was to ... -
In-depth bioinformatic study of the cadherin 5 interactome in patients with thoracic aortic aneurysm unveils 8 novel biomarkers
(2022)OBJECTIVES: Thoracic aortic aneurysm (TAA) is characterized by the dilation of the aorta and is associated with poor prognosis if not diagnosed and treated early. In this context, the identification of biomarkers regarding ... -
Interleukin 21 controls mRNAand MicroRNA expression in CD40-activated chronic lymphocytic leukemia cells
(2015)Several factors support CLL cell survival in the microenvironment. Under different experimental conditions, IL21 can either induce apoptosis or promote CLL cell survival. To investigate mechanisms involved in the effects ... -
Liver Expression of Sulphotransferase 2A1 Enzyme Is Impaired in Patients with Primary Sclerosing Cholangitis: Lack of the Response to Enhanced Expression of PXR
(2015)Background/Aim. Sulphotransferase 2A1 (SULT2A1) exerts hepatoprotective effects. Transcription of SULT2A1 gene is induced by pregnane-X-receptor (PXR) and can be repressed by miR-378a-5p. We studied the PXR/SULT2A1 axis ... -
microCLIP super learning framework uncovers functional transcriptome-wide miRNA interactions
(2018)Argonaute crosslinking and immunoprecipitation (CLIP) experiments are the most widely used high-throughput methodologies for miRNA targetome characterization. The analysis of Photoactivatable Ribonucleoside-Enhanced (PAR) ... -
microTSS: Accurate microRNA transcription start site identification reveals a significant number of divergent pri-miRNAs
(2014)A large fraction of microRNAs (miRNAs) are derived from intergenic non-coding loci and the identification of their promoters remains 'elusive'. Here, we present microTSS, a machine-learning algorithm that provides highly ... -
MirPub v2: Towards ranking and refining miRNA publication search results
(2015)In recent years, many articles studying microRNA (miRNA) molecules and their connection to diseases have been published. However, the wide range of literature in life sciences, raises a barrier in extracting useful information ... -
Molecular diagnostic testing for primary biliary cholangitis
(2016)Introduction: A reliable liver autoimmune serology for the diagnosis of primary biliary cholangitis (PBC) is of particular importance. Recognition of patients at early stages and prompt treatment initiation may alter the ... -
Multi-branch Convolutional Neural Network for Identification of Small Non-coding RNA genomic loci
(2020)Genomic regions that encode small RNA genes exhibit characteristic patterns in their sequence, secondary structure, and evolutionary conservation. Convolutional Neural Networks are a family of algorithms that can classify ... -
Online resources for miRNA analysis
(2013)Objective: This review aims to provide a brief introduction to each major category of available tools and algorithms for microRNA (miRNA) research, as well as to present some of the most widely used or promising representative ... -
Parkinson's disease and pesticides: Are microRNAs the missing link?
(2020)Parkinson's disease (PD) is a common neurodegenerative disorder that leads to significant morbidity and decline in the quality of life. It develops due to loss of dopaminergic neurons in the substantia nigra pars compacta, ... -
Publishing diachronic life science linked data
(2014)The Linked Data paradigm involves practices to publish, share, and connect data on the Web. Thus, it is a compelling approach for the dissemination and re-use of scientific data, realizing the vision of the so-called Linked ... -
The Role of MicroRNAs in Patients with Amyotrophic Lateral Sclerosis
(2018)Amyotrophic lateral sclerosis (ALS) is a serious neurodegenerative disease that affects motor neurons and leads to death within 2 to 3 years after the first symptoms manifest. MicroRNAs (miRNAs) are small non-coding RNA ... -
Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes
(2017)Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics ... -
Studying microRNAs in osteoarthritis: Critical overview of different analytical approaches
(2018)MicroRNAs are small non-coding RNA species with the ability to post-transcriptionally control the expression of multiple genes, that have gained substantial interest because of their expression alterations that accompanies ... -
The synergistic function of miR-140–5p and miR-146a on TLR4-mediated cytokine secretion in osteoarthritic chondrocytes
(2020)ΜiR-140–5p and miR-146a regulate inflammatory pathways including TLR4/NF-κB signaling and have been found to be involved in OA pathogenesis. In this study, we investigated the effect of the synergistic function of miR-140–5p ... -
Systemic control of legume susceptibility to rhizobial infection by a mobile microRNA
(2018)Nitrogen-fixing root nodules on legumes result from two developmental processes, bacterial infection and nodule organogenesis. To balance symbiosis and plant growth, legume hosts restrict nodule numbers through an inducible ... -
TarMiner: Automatic extraction of miRNA targets from literature
(2015)MicroRNAs (miRNAs) are small RNA molecules that tar-get particular genes and prohibit their expression. Since many important diseases are related to the expression or non-expression of particular genes, knowing the miRNAs ...