• The impact of combination therapy with a-blockers and 5ARIs on the progression of BPH 

      Sountoulides P., Gravas S. (2015)
      Benign prostatic hyperplasia (BPH) can be a progressive disease for some men with significant impact on their quality of life due to worsening of symptoms, risk of acute urinary retention (AUR) and surgery. Certain clinical ...
    • Impact of the financial crisis on COPD burden: Greece as a case study 

      Kotsiou O.S., Zouridis S., Kosmopoulos M., Gourgoulianis K.I. (2018)
      Poverty and low socioeconomic status have been associated with chronic obstructive pulmonary disease (COPD). The current financial crisis has forced millions back into poverty. Greece is one of the countries hit the hardest, ...
    • International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome 

      Jacobs B.C., van den Berg B., Verboon C., Chavada G., Cornblath D.R., Gorson K.C., Harbo T., Hartung H.-P., Hughes R.A.C., Kusunoki S., van Doorn P.A., Willison H.J., the IGOS Consortium, Jacobs B.C., Hughes R.A.C., Cornblath D.R., Gorson K.C., Hartung H.P., Kusunoki S., van Doorn P.A., Willison H.J., van Woerkom M., van den Berg B., Verboon C., Roodbol J., Jacobs B.C., Reisin R.C., Reddel S.W., Islam Z., Islam B., Mohammad Q.D., van den Bergh P., Feasby T.E., Wang Y.Z., Harbo T., Péréon Y., Hartung H.P., Lehmann H.C., Dardiotis E., Nobile-Orazio E., Kusunoki S., Shahrizaila N., Jacobs B.C., van den Berg B., Verboon C., Bateman K., Illa I., Querol L.A., Hsieh S.T., Willison H.J., Chavada G., Davidson A., Gorson K.C., Addington J.M., Ajroud-Driss S., Andersen H., Antonini G., Attarian S., Badrising U., Barroso F.A., Benedetti L., Beronio A., Bianco M., Binda D., Briani C., Bürmann J., Bella I.R., Bertorini T.E., Bhavaraju-Sanka R., Brannagan T.H., Busby M., Butterworth S., Campagnolo M., Casasnovas C., Cavaletti G., Chao C.S., Chen S., Chetty S., Claeys K.G., Cohen J.A., Conti M.E., Cosgrove J.S., Dalakas M.C., Dimachkie M.M., Dillmann U., Domínguez González C., Doppler K., Dornonville de la Cour C., Echaniz-Laguna A., Eftimov F., Faber C.G., Fazio R., Fokke C., Fujioka T., Fulgenzi E.A., Galassi G., Garcia T., Garnero M., Garssen M.P.J., Gijsbers C.J., Gilchrist J.M., Gilhuis H.J., Goldstein J.M., Goyal N., Granit V., Grapperon A., Gutiérrez Gutiérrez G., Gutmann L., Hadden R.D.M., Holbech J.V., Holt J.K.L., Homedes Pedret C., Htut M., Jellema K., Jericó Pascual I., Kaida K., Karafiath S., Katzberg H.D., Kiers L., Kieseier B.C., Kimpinski K., Kleyweg R.P., Kokubun N., Kolb N.A., Kuitwaard K., Kuwabara S., Kwan J.Y., Ladha S.S., Landschoff Lassen L., Lawson V., Ledingham D., Léon Cejas L., Luciano C.A., Lucy S.T., Lunn M.P.T., Magot A., Manji H., Marchesoni C., Marfia G.A.M., Márquez Infante C., Martinez Hernandez E., Mataluni G., Mattiazi M., McDermott C.J., Meekins G.D., Miller J., Monges M.S., Montero M.C.J., Morís de la Tassa G., Nascimbene C., Neumann C., Nowak R.J., Orizaola Balaguer P., Osei-Bonsu M., Pan E.B.L., Pardo Fernandez J., Pasnoor M., Pulley M.T., Rajabally Y.A., Rinaldi S., Ritter C., Roberts R.C., Rojas-Marcos I., Rudnicki S.A., Sachs G.M., Samijn J.P.A., Santoro L., Saperstein D.S., Savransky A., Schneider H., Schenone A., Sedano Tous M.J., Sekiguchi Y., Sheikh K.A., Silvestri N.J., Sindrup S.H., Sommer C.L., Stein B., Stino A.M., Spyropoulos A., Srinivasan J., Suzuki H., Taylor S.W., Tankisi H., Tigner D., Twydell P.T., Valzania F., van Damme P., van der Kooi A.J., van Dijk G.W., van der Ree T., van Koningsveld R., Varrato J.D., Vermeij F.H., Verschuuren J.J.G.M., Visser L.H., Vytopil M.V., Waheed W., Wilken M., Wilkerson C., Wirtz P.W., Yamagishi Y., Yiu E.M., Zhou L., Zivkovic S. (2017)
      Guillain-Barré syndrome (GBS) is an acute polyradiculoneuropathy with a highly variable clinical presentation, course, and outcome. The factors that determine the clinical variation of GBS are poorly understood which ...
    • Joint involvement in systemic lupus erythematosus: From pathogenesis to clinical assessment 

      Ceccarelli F., Perricone C., Cipriano E., Massaro L., Natalucci F., Capalbo G., Leccese I., Bogdanos D., Spinelli F.R., Alessandri C., Valesini G., Conti F. (2017)
      Objective In the present review, the different phenotypes, clinimetric and imaging tools able to assess joint involvement in patients affected by Systemic Lupus Erythematosus (SLE) have been described and summarized. ...
    • Lapatinib with whole brain radiotherapy in patients with brain metastases from breast and non-small cell lung cancer: a phase II study of the Hellenic Cooperative Oncology Group (HeCOG) 

      Christodoulou C., Kalogera-Fountzila A., Karavasilis V., Kouvatseas G., Papandreou C.N., Samantas E., Varaki K., Papadopoulos G., Bobos M., Rallis G., Razis E., Goudopoulou A., Kalogeras K.T., Syrigos K.N., Fountzilas G. (2017)
      Small molecules, mainly tyrosine kinase inhibitors, are currently used in various malignancies. Lapatinib, a dual inhibitor of EGFR/HER2 tyrosine kinases, has demonstrated effectiveness in brain metastases from HER2-overexpressing ...
    • Lateralization of Insular Ischemic Stroke is Not Associated With Any Stroke Clinical Outcomes: The Athens Stroke Registry 

      Vassilopoulou S., Korompoki E., Tountopoulou A., Mitsikostas D.D., Manios E., Georgiopoulos G., Ntaios G., Milionis H., Fontara S., Vemmos K. (2020)
      Background: Controversial evidence suggests that right insular stroke may be associated with worse outcomes compared to the left insular ischemic lesion. Objectives: We investigated whether lateralization of insular stroke ...
    • Leukotriene-receptor antagonists versus placebo in the treatment of asthma in adults and adolescents a systematic review and meta-analysis 

      Miligkos M., Bannuru R.R., Alkofide H., Kher S.R., Schmid C.H., Balk E.M. (2015)
      Background: Leukotriene-receptor antagonists (LTRAs) are recommended as an alternative treatment in patients with mild asthma, but their effect compared with placebo is unclear. Purpose: To determine the benefits and harms ...
    • Lymph Node Cellular Dynamics in Cancer and HIV: What Can We Learn for the Follicular CD4 (Tfh) Cells? 

      Poultsidi A., Dimopoulos Y., He T.-F., Chavakis T., Saloustros E., Lee P.P., Petrovas C. (2018)
      Lymph nodes (LNs) are central in the generation of adaptive immune responses. Follicular helper CD4 T (Tfh) cells, a highly differentiated CD4 population, provide critical help for the development of antigen-specific B ...
    • Major hepatic complications in ursodeoxycholic acid-treated patients with primary biliary cholangitis: Risk factors and time trends in incidence and outcome 

      Harms M.H., Lammers W.J., Thorburn D., Corpechot C., Invernizzi P., Janssen H.L.A., Battezzati P.M., Nevens F., Lindor K.D., Floreani A., Ponsioen C.Y., Mayo M.J., Dalekos G.N., Bruns T., Parés A., Mason A.L., Verhelst X., Kowdley K.V., Goet J.C., Hirschfield G.M., Hansen B.E., Van Buuren H.R. (2018)
      Objectives: In this era of near universal ursodeoxycholic acid (UDCA) treatment for primary biliary cholangitis (PBC), progression to cirrhosis still occurs in an important proportion of patients. The aim of this study was ...
    • MRI of the hip: Current concepts on bone marrow oedema 

      Klontzas M.E., Zibis A.H., Vassalou E.E., Karantanas A.H. (2017)
      Bone marrow oedema (BME) is commonly found in hip MR imaging. BME is a nonspecific finding which can be related to a wide variety of diseases. However, there are cases where its existence or its pattern can narrow the ...
    • Obstructive sleep disordered breathing in 2- to 18-year-old children: Diagnosis and management 

      Kaditis A.G., Alvarez M.L.A., Boudewyns A., Alexopoulos E.I., Ersu R., Joosten K., Larramona H., Miano S., Narang I., Trang H., Tsaoussoglou M., Vandenbussche N., Villa M.P., Waardenburg D.V., Weber S., Verhulst S. (2016)
      This document summarises the conclusions of a European Respiratory Society Task Force on the diagnosis and management of obstructive sleep disordered breathing (SDB) in childhood and refers to children aged 2-18 years. ...
    • Occult hepatitis B virus infection in Greek patients with chronic hepatitis C and in patients with diverse nonviral hepatic diseases 

      Georgiadou, S. P.; Zachou, K.; Rigopoulou, E.; Liaskos, C.; Mina, P.; Gerovasilis, F.; Makri, E.; Dalekos, G. N. (2004)
      Occult hepatitis B virus (HBV) infection has been reported in patients with chronic hepatitis C who are negative for HBV surface antigen (HBsAg). However, the significance of 'silent' HBV in hepatitis C virus (HCV) infection ...
    • Osteonecrosis of the femoral head: Etiology, imaging and treatment 

      Malizos, K. N.; Karantanas, A. H.; Varitimidis, S. E.; Dailiana, Z. H.; Bargiotas, K.; Maris, T. (2007)
      Osteonecrosis of the femoral head is a disabling clinical entity affecting young adults that usually leads to destruction of the hip joint. A high index of suspicion is necessary for the diagnosis due to the insidious onset ...
    • Patient Age, Sex, and Inflammatory Bowel Disease Phenotype Associate With Course of Primary Sclerosing Cholangitis 

      Weismüller T.J., Strassburg C.P., Trivedi P.J., Hirschfield G.M., Trivedi P.J., Bergquist A., Said K., Imam M., Lazaridis K.N., Juran B.D., Cheung A., Lindor K.D., Weismüller T.J., Lenzen H., Manns M.P., Ponsioen C.Y., Beuers U., Holm K., Naess S., Karlsen T.H., Schrumpf E., Boberg K.M., Gotthardt D., Rupp C., Färkkilä M.A., Jokelainen K., Marschall H.-U., Benito de Valle M., Thorburn D., Saffioti F., Weersma R.K., Fevery J., Mueller T., Chazouillères O., Schulze K., Schramm C., Almer S., Pereira S.P., Levy C., Mason A., Bowlus C.L., Floreani A., Halilbasic E., Trauner M., Yimam K.K., Milkiewicz P., Milkiewicz P., Huynh D.K., Pares A., Manser C.N., Dalekos G.N., Eksteen B., Invernizzi P., Berg C.P., Kirchner G.I., Sarrazin C., Zimmer V., Fabris L., Braun F., Marzioni M., Schramm C., Chapman R.W., Chapman R.W., Lindor K.D., Imam M., Lindor K.D., Naess S., Karlsen T.H., Schrumpf E., Boberg K.M., Hansen B.E., Hansen B.E., Hansen B.E., on behalf of the, International PSC Study Group (2017)
      Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of disease progression based on distinct clinical ...
    • Postacute sequelae of SARS-CoV-2 infection. Osteonecrosis must not be overlooked 

      Koutalos A.A., Stefanou N., Malizos K.N. (2022)
      Recovery from COVID-19 is not always uneventful, especially in critically ill hospitalized patients. Persistent symptoms including fatigue/ weakness, shortness of breath, anxiety, and depression have been described at ...
    • Primary High-Grade Non-Muscle-Invasive Bladder Cancer: High NFκB Expression in Tumor Specimens Distinguishes Patients Who are at Risk for Disease Progression 

      Mitrakas L., Gravas S., Papandreou C., Koukoulis G., Karasavvidou F., Dimakopoulos G., Weingärtner K., Karatzas A., Zachos I., Tzortzis V. (2019)
      To investigate the potential prognostic role of NFκB expression in primary high-grade non-muscle-invasive bladder cancer. Patients with primary high-grade non-muscle-invasive bladder cancer who received induction and ...
    • Progression into sepsis: An individualized process varying by the interaction of comorbidities with the underlying infection 

      Sinapidis D., Kosmas V., Vittoros V., Koutelidakis I.M., Pantazi A., Stefos A., Katsaros K.E., Akinosoglou K., Bristianou M., Toutouzas K., Chrisofos M., Giamarellos-Bourboulis E.J. (2018)
      Background: Development of sepsis is a process with significant variation among individuals. The precise elements of this variation need to be defined. This study was designed to define the way in which comorbidities ...
    • Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium 

      Bahls M., Lorenz M.W., Dörr M., Gao L., Kitagawa K., Tuomainen T.-P., Agewall S., Berenson G., Catapano A.L., Norata G.D., Bots M.L., van Gilst W., Asselbergs F.W., Brouwers F.P., Uthoff H., Sander D., Poppert H., Hecht Olsen M., Empana J.P., Schminke U., Baldassarre D., Veglia F., Franco O.H., Kavousi M., de Groot E., Mathiesen E.B., Grigore L., Polak J.F., Rundek T., Stehouwer C.D.A., Skilton M.R., Hatzitolios A.I., Savopoulos C., Ntaios G., Plichart M., McLachlan S., Lind L., Willeit P., Steinmetz H., Desvarieux M., Ikram M.A., Johnsen S.H., Schmidt C., Willeit J., Ducimetiere P., Price J.F., Bergström G., Kauhanen J., Kiechl S., Sitzer M., Bickel H., Sacco R.L., Hofman A., Völzke H., Thompson S.G., on behalf of the PROG-IMT Study Group (2020)
      Aims: Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for ...
    • Seasonal adherence to, and effectiveness of, subcutaneous interferon β-1a administered by RebiSmart® in patients with relapsing multiple sclerosis: Results of the 1-year, observational GEPAT-SMART study 

      Deftereos S.N., Koutlas E., Koutsouraki E., Kyritsis A., Papathanassopoulos P., Fakas N., Tsimourtou V., Vlaikidis N., Tavernarakis A., Voumvourakis K., Arvanitis M., Sakellariou D., Delorenzo F. (2018)
      Background: Little is known about whether tolerability and adherence to treatment can be influenced by weather and temperature conditions. The objective of this study was to assess monthly and seasonal adherence to and ...
    • Smoking as a risk factor for autoimmune liver disease: What we can learn from primary biliary cirrhosis 

      Smyk, D. S.; Rigopoulou, E. I.; Muratori, L.; Burroughs, A. K.; Bogdanos, D. P. (2012)
      Primary biliary cirrhosis (PBC) is a cholestatic liver disease characterised by the immune-mediated destruction of biliary epithelial cells in small intrahepatic bile ducts. The disease is characterised by circulating ...