Πλοήγηση ανά Συγγραφέα "Tsezou, A."
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The canine copper toxicosis gene MURR1 is not implicated in the pathogenesis of Wilson disease
Lovicu, M.; Dessi, V.; Lepori, M. B.; Zappu, A.; Zancan, L.; Giacchino, R.; Marazzi, M. G.; Iorio, R.; Vegnente, A.; Vajro, P.; Maggiore, G.; Marcellini, M.; Barbera, C.; Kostic, V.; Farci, A. M. G.; Solinas, A.; Altuntas, B.; Yuce, A.; Kocak, N.; Tsezou, A.; De Virgiliis, S.; Cao, A.; Loudianos, G. (2006)Background. It has recently been demonstrated that the Wilson disease (WD) protein directly interacts with the human homolog of the MURR1 protein in vitro and in vivo, and that this interaction is specific for the copper ... -
The Catabolic Role of Toll-Like Receptor 2 (TLR-2) Mediated by the NF-kappa B Pathway in Septic Arthritis
Papathanasiou, I.; Malizos, K. N.; Poultsides, L.; Karachalios, T.; Oikonomou, P.; Tsezou, A. (2011)Toll-like receptors (TLRs) are involved in mediating cell activation on stimulation with microbial components. Our objective was to investigate the role of 'PLR-2 mediated by the NF-kappa B pathway in septic arthritic ... -
Central Role of SREBP-2 in the Pathogenesis of Osteoarthritis
Kostopoulou, F.; Gkretsi, V.; Malizos, K. N.; Iliopoulos, D.; Oikonomou, P.; Poultsides, L.; Tsezou, A. (2012)Background: Recent studies have implied that osteoarthritis (OA) is a metabolic disease linked to deregulation of genes involved in lipid metabolism and cholesterol efflux. Sterol Regulatory Element Binding Proteins (SREBPs) ... -
Chorionic villi derived mesenchymal stem cells and expression of embryonic stem cells markers
Katsiani, E.; Garas, A.; Skentou, C.; Tsezou, A.; Dafopoulos, K.; Messinis, I. E. (2012) -
Clinical and molecular description of a fetus in prenatal diagnosis with a rare de novo ring 10 and deletions of 12.59 Mb in 10p15.3-p14 and 4.22 Mb in 10q26.3
Christopoulou, G.; Tzetis, M.; Konstantinidou, A. E.; Tsezou, A.; Kanavakis, E.; Kitsiou-Tzeli, S.; Velissariou, V. (2012)Ring chromosomes are rare cytogenetic findings and are mostly associated with an abnormal phenotype. We report on the prenatal diagnosis of a ring chromosome 10 in a fetus in which talipes equinovarus was incidentally found ... -
Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis
Athanasiadou, A.; Stamatopoulos, K.; Tsompanakou, A.; Gaitatzi, M.; Kalogiannidis, P.; Anagnostopoulos, A.; Fassas, A.; Tsezou, A. (2006)In a cohort of 130 unselected chronic lymphocytic leukemia (CLL) patients, 73 cases had normal karyotypes, 57 cases had abnormal karyotypes, and 22/57 cases carried more than one abnormality. Trisomy 12 (+ 12) was the most ... -
Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
Kerkhof, H. J. M.; Meulenbelt, I.; Carr, A.; Gonzalez, A.; Hart, D.; Hofman, A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Nevitt, M. C.; Pols, H. A. P.; Rivadeneira, F.; Slagboom, E. P.; Spector, T. D.; Stolk, L.; Tsezou, A.; Uitterlinden, A. G.; Valdes, A. M.; van Meurs, J. B. J. (2010)Background: The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis. Methods: In the discovery study, the Rotterdam Study-I, 7 single nucleotide ... -
Contribution of the CFTR gene, the pancreatic secretory trypsin inhibitor gene (SPINK1) and the cationic trypsinogen gene (PRSS1) to the etiology of recurrent pancreatitis
Tzetis, M.; Kaliakatsos, M.; Fotoulaki, B.; Papatheodorou, A.; Doudounakis, S.; Tsezou, A.; Makrythanasis, P.; Kanavakis, E.; Nousia-arvanitakis, S. (2007)Acute recurrent/chronic pancreatitis (CP) is a complex multigenic disease. This is a case-control study consisting of 25 Greek patients with CP and a control population of 236 healthy Greek subjects. The whole coding area ... -
Correlation between radiation-induced telomerase activity and human telomerase reverse transcriptase mRNA expression in HeLa cells
Satra, M.; Tsougos, I.; Papanikolaou, V.; Theodorou, K.; Kappas, C.; Tsezou, A. (2006)Purpose: To quantify and correlate human telomerase reverse transcriptase (hTERT) mRNA expression with telomerase activity (TA) after ionizing irradiation of HeLa cells. Materials and methods: TA and hTERT mRNA expression ... -
Correlation of promoter hypermethylation in hTERT, DAPK and MGMT genes with cervical oncogenesis progression
Iliopoulos, D.; Oikonomou, P.; Messinis, I.; Tsezou, A. (2009)DNA hypermethylation occurs during the multi-step process of cervical carcinogenesis. We investigated whether the methylation status in the promoter region of a potential oncogene, the human telomerase reverse transcriptase ... -
DEEP SEQUENCING OF GDF5 IN OVER 1900 OSTEOARTHRITIS CASES AND CONTROLS REVEALS NOVEL AND POTENTIALLY FUNCTIONAL RARE VARIANTS IN THE PROTEIN CODING AND PROMOTER REGIONS OF THE GENE
Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Gonzalez, A.; Loughlin, J. (2010) -
Deep sequencing of GDF5 reveals the absence of rare variants at this important osteoarthritis susceptibility locus
Dodd, A. W.; Rodriguez-Fontenla, C.; Calaza, M.; Carr, A.; Gomez-Reino, J. J.; Tsezou, A.; Reynard, L. N.; Gonzalez, A.; Loughlin, J. (2011)Objective: The common single nucleotide polymorphism (SNP) rs143383 in the 5' untranslated region (5'UTR) of growth and differentiation factor 5 (GDF5) is strongly associated with osteoarthritis (OA) and influences GDF5 ... -
Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism
Simopoulou, T.; Malizos, K. N.; Iliopoulos, D.; Stefanou, N.; Papatheodorou, L.; Ioannou, M.; Tsezou, A. (2007)Objective: To investigate leptin's effect on cartilage metabolism and the pathophysiology of osteoarthritis (OA). Methods: Messenger RNA (mRNA) expression and protein levels of leptin and leptin's receptor isoforms were ... -
DNA methylation is not likely to be responsible for hTERT expression in premalignant cervical lesions
Oikonomou, P.; Messinis, I.; Tsezou, A. (2007)Human telomerase reverse transcriptase (hTERT) MRNA expression seems to play an important role in cervical carcinogenesis. Analysis of the hTERT promoter region revealed the presence of a CpG island and a high overall GC ... -
DNA methylation regulates sclerostin (SOST) expression in osteoarthritic chondrocytes by bone morphogenetic protein 2 (BMP-2) induced changes in Smads binding affinity to the CpG region of SOST promoter
Papathanasiou, I.; Kostopoulou, F.; Malizos, K. N.; Tsezou, A. (2015)Introduction: Sclerostin (SOST), a soluble antagonist of Wnt signaling, is expressed in chondrocytes and contributes to chondrocytes' hypertrophic differentiation; however its role in osteoarthritis (OA) pathogenesis is ... -
Epigenetic regulation of hTERT promoter in hepatocellular carcinomas
Iliopoulos, D.; Satra, M.; Drakaki, A.; Poultsides, G. A.; Tsezou, A. (2009)Although hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, the molecular pathogenesis of the disease has not been elucidated. Several studies have shown that telomerase activity and hTERT expression ... -
Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention
Iliopoulos, D.; Malizos, K. N.; Tsezou, A. (2007)Objective: To investigate whether epigenetic mechanisms can regulate leptin's expression and affect its downstream targets as metalloproteinases 3,9,13 in osteoarthritic chondrocytes. Methods: DNA methylation in leptin ... -
Erratum to A genome-wide association study identifies a common variant near the GPR22 gene as a new locus involved in prevalence and progression of osteoarthritis [Bone, 44S2 (2009) S224]
Kerkhof, H. J. M.; Lories, R. J.; Meulenbelt, I.; Jonsdottir, I.; Valdes, A. M.; Arp, P.; Ingvarsson, T.; Jhamai, M.; Jonsson, H.; Stolk, L.; Thorleifsson, G.; Zhai, G.; Zhang, F.; Zhu, Y.; van der Breggen, R.; Carr, A.; Doherty, M.; Doherty, S.; Felson, D. T.; Gonzalez, A.; Halldorsson, B. V.; Hart, D. J.; Hauksson, V. B.; Hofman, A.; Ioannidis, J. P. A.; Kloppenburg, M.; Lane, N. E.; Loughlin, J.; Luyten, F. P.; Nevitt, M. C.; Parimi, N.; Pols, H. A. P.; van de Putte, T.; Rivadeneira, F.; Slagboom, E. P.; Styrkársdóttir, U.; Tsezou, A.; Zmuda, J.; Spector, T. D.; Stefansson, K.; Uitterlinden, A. G.; van Meurs, J. B. J. (2010) -
Evaluation of MMP1 and MMP3 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma
Tsironi, E. E.; Pefkianaki, M.; Tsezou, A.; Kotoula, M. G.; Dardiotis, E.; Almpanidou, P.; Papathanasiou, A. A.; Rodopoulou, P.; Chatzoulis, D. Z.; Hadjigeorgiou, G. M. (2009)Purpose: To investigate possible genetic associations of matrix metalloproteinase-1 (MMP1) and MMP3 gene polymorphisms with exfoliation syndrome (XFS) with (XFS/+G) and without (XFS/-G) glaucoma in a cohort of Greek patients. ... -
Factors associated with the development of superficial vein thrombosis in patients with varicose veins
Karathanos, C.; Exarchou, M.; Tsezou, A.; Kyriakou, D.; Wittens, C.; Giannoukas, A. (2013)Introduction: Superficial vein thrombosis (SVT) is a common and controversial clinical entity. Recent studies have demonstrated that SVT should be seen as a venous thromboembolism (VTE). The objective of this study was to ...