• Prevalence of HPV16 E1-1374 boolean AND 63nt variants in Greek women 

      Tsakogiannis, D.; Kyriakopoulou, Z.; Darmis, F.; Ruether, I. G. A.; Dimitriou, T. G.; Orfanoudakis, G.; Panotopoulou, E.; Markoulatos, P. (2014)
      Recent studies have focused on sequence variation of the HPV16 E1 gene. The present study investigates the prevalence of E1-1374<^>63nt duplication in the Greek population, and the sequence variation at the 5 ' end of the ...
    • Retrospective molecular and phenotypic analysis of poliovirus vaccine strains isolated in Greece 

      Pliaka, V.; Filliponi, M. E.; Kyriakopoulou, Z.; Ruether, I. G. A.; Tsakogiannis, D.; Gartzonika, C.; Levidiotou-Stefanou, S.; Markoulatos, P. (2011)
      The live oral poliovirus vaccine (OPV) strains are genetically unstable, causing, in rare cases, vaccine-associated paralytic poliomyelitis. Reversions of the known attenuating mutations in OPV strains and intertypic ...
    • Sequence variation analysis of the E2 gene of human papilloma virus type 16 in cervical lesions from women in Greece 

      Tsakogiannis, D.; Ruether, I. G. A.; Kyriakopoulou, Z.; Pliaka, V.; Theoharopoulou, A.; Skordas, V.; Panotopoulou, E.; Nepka, C.; Markoulatos, P. (2012)
      The E2 gene of human papilloma virus is expressed at the early stage of the viral life cycle, encoding the E2 transcription factor, and regulates the expression of E6 and E7 oncogenes. Disruption of E2 gene due to viral ...
    • Sites of disruption within E1 and E2 genes of HPV16 and association with cervical dysplasia 

      Tsakogiannis, D.; Gortsilas, P.; Kyriakopoulou, Z.; Ruether, I. G. A.; Dimitriou, T. G.; Orfanoudakis, G.; Markoulatos, P. (2015)
      Integration of HPV16 DNA into the host chromosome usually disrupts the E1 and/or E2 genes. The present study investigated the disruption of E1, E2 genes in a total of eighty four HPV16-positive precancerous and cervical ...