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dc.creatorVoutetakis, A.en
dc.creatorSertedaki, A.en
dc.creatorLivadas, S.en
dc.creatorManiati-Christidi, M.en
dc.creatorMademtzis, I.en
dc.creatorBossis, I.en
dc.creatorDacou-Voutetakis, C.en
dc.creatorMessinis, I. E.en
dc.date.accessioned2015-11-23T10:54:04Z
dc.date.available2015-11-23T10:54:04Z
dc.date.issued2004
dc.identifier10.1016/j.fertnstert.2004.03.026
dc.identifier.issn0015-0282
dc.identifier.urihttp://hdl.handle.net/11615/34641
dc.description.abstractObjective: To describe ovulation induction and pregnancy outcome in a unique model of genetically determined combined pituitary hormone deficiency (CPHD), with respect to the necessity for GH substitution therapy. Design: Case report. Setting: Academic units. Patient(s): Two patients with childhood onset of CPHD (GH, PRL, TSH, LH, FSH) caused by a genetic defect (GA296del mutation) of the Prop1 gene. Main Outcome Measure(s): Ovulation, pregnancy outcome, and fetal growth. Result(s): Successful pregnancy outcome and delivery of normal, full-term newborns were achieved in both patients with the use of gonadotropins and L-T, Growth hormone supplementation was not necessary. No lactation was observed. Conclusion(s): Patients with Prop1 gene mutations constitute a unique model for studying the role of GH and PRL in ovulation, pregnancy, and fetal growth. Our data indicate that for women with CPHD, ovulation and pregnancy are possible with a classic regimen for hypogonadotropic hypogonadism, without the need for GH substitution therapy. (Fertil Steril((R)) 2004;82:454-7. (C) 2004 by American Society for Reproductive Medicine.).en
dc.source.uri<Go to ISI>://WOS:000223263000033
dc.subjectcombined pituitary hormone deficiencyen
dc.subjectgrowth hormoneen
dc.subjectovulationen
dc.subjectprolactinen
dc.subjectProp1en
dc.subjectIN-VITRO FERTILIZATIONen
dc.subjectPITUITARY-HORMONE DEFICIENCYen
dc.subjectBIOSYNTHETICen
dc.subjectGROWTH-HORMONEen
dc.subjectOVARIAN STIMULATIONen
dc.subjectPOOR RESPONDERen
dc.subjectWOMENen
dc.subjectGONADOTROPINen
dc.subjectPROLACTINen
dc.subjectSUBSTITUTIONen
dc.subjectCOTREATMENTen
dc.subjectObstetrics & Gynecologyen
dc.subjectReproductive Biologyen
dc.titleOvulation induction and successful pregnancy outcome in two patients with Prop1 gene mutationsen
dc.typejournalArticleen


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