Safety of moxidectin 1% injectable solution and 0.1% oral drench for lambs younger than one month
Two hundred lambs, 4-29 days old, were segregated into eight groups; lambs in Group A were injected with a single dose of moxidectin 1% inj. sol. (0.2 mg kg(-1) bodyweight), those in Group C were injected with a quadruple one (0.8 mg kg(-1) bodyweight), those in Group E with a single dose of moxidectin 0.1% or. dr. (0.2 mg kg(-1) bodyweight) and those in Group G with a decuple oral dose (2 mg kg(-1) bodyweight); lambs in groups B, D, F and H were the controls. The reactions of lambs were recorded for 14 days after administration of the test product. The only adverse reaction observed was in one Group C lamb, which became indifferent to the environment and laid down in a corner of the pen after administration; this regressed within 12 h without any particular medical treatment of the lamb and was not statistically significant. It is concluded that moxidectin is safe for administration to young lambs. (C) 1999 Elsevier Science B.V. All rights reserved.