Show simple item record

dc.creatorToloudi, M.en
dc.creatorIoannou, E.en
dc.creatorChatziioannou, M.en
dc.creatorApostolou, P.en
dc.creatorKiritsis, C.en
dc.creatorManta, S.en
dc.creatorKomiotis, D.en
dc.creatorPapasotiriou, I.en
dc.date.accessioned2015-11-23T10:50:06Z
dc.date.available2015-11-23T10:50:06Z
dc.date.issued2014
dc.identifier.issn1574-888X
dc.identifier.urihttp://hdl.handle.net/11615/33676
dc.description.abstractA fundamental problem in cancer research is identification of the cells responsible for tumor formation. The latest field of cancer research has revealed the existence and role of cancer stem cells (CSCs). These findings support the idea that malignancies originate from a small fraction of cancer cells that show self-renewal and multi-or pluripotency. Identification of this CSC population has important implications for the management of cancer patients, including diagnostic and predictive laboratory assays as well as novel therapeutic strategies that specifically target CSCs. In this study, we investigated the growth rates of CSC populations for comparison with cancer cell lines. To construct the growth curves, blood-derived CSCs were isolated from patients with breast, colon, or lung cancer and cultured in vitro. Quantitative real-time PCR was then performed to identify CSCs in the samples. We found that CSCs did not follow the common pattern of a typical growth curve of mammalian cells in contrast to the cancer cell lines. This observation of rapidly growing CSCs indicates their involvement in tumor formation.en
dc.source.uri<Go to ISI>://WOS:000331890000005
dc.subjectCancer stem cellsen
dc.subjectgrowth curvesen
dc.subjectNanogen
dc.subjectOct3/4en
dc.subjectSox2en
dc.subjectCIRCULATING TUMOR-CELLSen
dc.subjectNANOGen
dc.subjectOCT-4en
dc.subjectPCRen
dc.subjectCell & Tissue Engineeringen
dc.subjectCell Biologyen
dc.titleComparison of the Growth Curves of Cancer Cells and Cancer Stem Cellsen
dc.typejournalArticleen


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record