Risks associated with the use of live-attenuated vaccine poliovirus strains and the strategies for control and eradication of paralytic poliomyelitis
Ημερομηνία
2012Λέξη-κλειδί
Επιτομή
The Global Polio Eradication Initiative was launched in 1988 with the aim to eliminate paralytic poliomyelitis. Two effective vaccines are available: inactivated polio vaccine (IPV) and oral polio vaccine (OPV). Since 1964, OPV has been used instead of IPV in most countries due to several economic and biological advantages. However, in rare cases, the live-attenuated Sabin strains of OPV revert to neurovirulence and cause vaccine-associated paralytic poliomyelitis in vaccinees or lead to emergence of vaccine-derived poliovirus strains. Attenuating mutations and recombination events have been associated with the reversion of vaccine strains to neurovirulence. The substitution of OPV with an improved new-generation IPV and the availability of new specific drugs against polioviruses are considered as future strategies for outbreak control and the eradication of paralytic poliomyelitis worldwide.
Collections
Related items
Showing items related by title, author, creator and subject.
-
A cross-sectional vaccination coverage study in preschool children attending nurseries-kindergartens: Implications on economic crisis effect
Georgakopoulou T., Menegas D., Katsioulis A., Theodoridou M., Kremastinou J., Hadjichristodoulou C. (2017)Vaccination coverage studies are important in determining a population's vaccination status and strategically adjusting national immunization programs. This study assessed full and timely vaccination coverage of preschool ... -
Are younger COPD patients adequately vaccinated for influenza and pneumococcus?
Gogou E., Hatzoglou C., Zarogiannis S.G., Siachpazidou D., Gerogianni I., Kotsiou O.S., Varsamas C., Gourgoulianis K.I. (2022)Influenza and pneumococcal pneumonia are major causes of increased morbidity and mortality among elderly and COPD patients. Vaccines against influenza and pneumococcus are recommended for COPD patients according to GOLD ... -
Factors associated with healthcare workers’ (HCWs) acceptance of COVID-19 vaccinations and indications of a role model towards population vaccinations from a cross-sectional survey in Greece, may 2021
Fotiadis K., Dadouli K., Avakian I., Bogogiannidou Z., Mouchtouri V.A., Gogosis K., Speletas M., Koureas M., Lagoudaki E., Kokkini S., Bolikas E., Diamantopoulos V., Tzimitreas A., Papadopoulos C., Farmaki E., Sofos A., Chini Μ., Tsolia M., Papaevangelou V., Ntzani E.E., Gikas A., Prezerakos P., Hadjichristodoulou C. (2021)A Knowledge, Attitudes and Practices (KAP) study was conducted at the end of May 2021 engaging 1456 healthcare workers (HCWs) from 20 hospitals throughout Greece. Acceptance of vaccination against coronavirus disease 2019 ...