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dc.creatorMarkoulaki, D.en
dc.creatorKostikas, K.en
dc.creatorPapatheodorou, G.en
dc.creatorKoutsokera, A.en
dc.creatorAlchanatis, M.en
dc.creatorBakakos, P.en
dc.creatorGourgoulianis, K. I.en
dc.creatorRoussos, C.en
dc.creatorKoulouris, N. G.en
dc.creatorLoukides, S.en
dc.date.accessioned2015-11-23T10:38:59Z
dc.date.available2015-11-23T10:38:59Z
dc.date.issued2011
dc.identifier10.1016/j.ejim.2010.07.010
dc.identifier.issn0953-6205
dc.identifier.urihttp://hdl.handle.net/11615/30747
dc.description.abstractBackground: Systemic inflammation may represent a possible cause of anemia. Previous data support that anemic patients with COPD present high erythropoietin (EPO) levels, suggestive of EPO resistance, possibly mediated through inflammatory mechanisms. Objectives: We aimed to determine whether systemic inflammation, which is usually up-regulated during exacerbations of COPD (ECOPD) is associated with low hemoglobin levels expressing erythropoietin resistance. Methods: Hemoglobin (Hb), EPO and serum biomarkers of systemic inflammation [CRP, TNF-alpha, fibrinogen and IL-6] were assessed at three time points (admission, resolution and stable phases) in a selected cohort of 93 COPD patients. Results: Hemoglobin levels were significantly lower on admission compared to resolution and stable phases (median 12.1 g/dl [interquartile ranges 11.2-12.7], vs 13.5 [12.4-14.3] vs 13.4 [12.7-14.08], respectively p = 0.002), whereas EPO was significantly higher on admission compared to resolution and stable phases. A negative association between Hb and IL-6 and a positive association between EPO and IL-6 were observed only during the acute phase of exacerbation. EPO and Hb were negatively associated during the acute phase, whereas they were positively associated during discharge and stable phase. Conclusions: In this observational study we have shown that during admission for ECOPD Hb levels are decreased and EPO levels are increased. We have also identified a negative association between Hb and EPO. The above association is mainly related to increased IL-6 levels, indicating a possible EPO resistance through the mechanism of increased systemic inflammatory process. (C) 2010 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.en
dc.source.uri<Go to ISI>://WOS:000286191400022
dc.subjectAnemiaen
dc.subjectCOPDen
dc.subjectExacerbationsen
dc.subjectSystemic inflammationen
dc.subjectErythropoietinen
dc.subjectRHEUMATOID-ARTHRITISen
dc.subjectANEMIAen
dc.subjectDIAGNOSISen
dc.subjectRECOVERYen
dc.subjectTHERAPYen
dc.subjectIMPACTen
dc.subjectMedicine, General & Internalen
dc.titleHemoglobin, erythropoietin and systemic inflammation in exacerbations of chronic obstructive pulmonary diseaseen
dc.typejournalArticleen


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