Exhaled Nitric Oxide in Asthma in Adults: The End is the Beginning?
Approximately 20 years after the initial report of the measurement of exhaled nitric oxide (NO) in the exhaled air of humans, numerous publications have evaluated the possible applications of the fraction of exhaled NO (FeNO) in patients with asthma. The aim of the present review is to evaluate the technical issues and confounding factors related to FeNO measurements, as well as the role of FeNO in the diagnosis of asthma, the evaluation of asthmatic patients and the guidance of treatment. Several other issues, including the pursuit for "normal" and best personal values, the prediction of clinically relevant asthma outcomes and the identification of asthma phenotypes and future directions are discussed. FeNO represents the only exhaled biomarker that has reached clinical practice even in primary care settings and this review provides a critical view of the possible applications of this biomarker, both for the basic researcher and the clinician.
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Gourgoulianis, K. I.; Chatziparasidis, G.; Chatziefthimiou, A.; Molyvdas, P. A. (2001)in the search for effective treatment of a life-threatening asthma attack, intravenous magnesium infusion has been studied in asthmatic patients because of its potential effect to reverse bronchospasm and improve pulmonary ...
Interactions of Obstructive Sleep-Disordered Breathing With Recurrent Wheezing or Asthma and Their Effects on Sleep Quality Malakasioti, G.; Gourgoulianis, K.; Chrousos, G.; Kaditis, A. (2011)Snoring is the most characteristic symptom of obstructive sleep-disordered breathing ( SDB) and recurrent wheezing is the most common clinical manifestation of asthma. The purpose of the present review is to outline the ...
Gourgoulianis, K. I.; Gogou, E.; Hamos, V.; Molyvdas, P. A. (2002)The aim of this study was to evaluate the effects of indoor smoking. Exhaled carbon monoxide WO) concentrations were measured on a CO monitor by a vital capacity manoeuvre in three groups of adolescents: non-smokers with ...