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dc.creatorKemlink, D.en
dc.creatorPolo, O.en
dc.creatorMontagna, P.en
dc.creatorProvini, F.en
dc.creatorStiasny-Kolster, K.en
dc.creatorOertel, W.en
dc.creatorde Weerd, A.en
dc.creatorNevsimalova, S.en
dc.creatorSonka, K.en
dc.creatorHogl, B.en
dc.creatorFrauscher, B.en
dc.creatorPoewe, W.en
dc.creatorTrenkwalder, C.en
dc.creatorPramstaller, P. P.en
dc.creatorFerini-Strambi, L.en
dc.creatorZucconi, M.en
dc.creatorKonofal, E.en
dc.creatorArnulf, I.en
dc.creatorHadjigeorgiou, G. M.en
dc.creatorHappe, S.en
dc.creatorKlein, C.en
dc.creatorHiller, A.en
dc.creatorLichtner, P.en
dc.creatorMeitinger, T.en
dc.creatorMuller-Myshok, B.en
dc.creatorWinkelmann, J.en
dc.date.accessioned2015-11-23T10:34:35Z
dc.date.available2015-11-23T10:34:35Z
dc.date.issued2007
dc.identifier10.1002/mds.21254
dc.identifier.issn0885-3185
dc.identifier.urihttp://hdl.handle.net/11615/29357
dc.description.abstractThree loci for the restless legs syndrome (RLS) on chromosomes 12q, 14q, and 9p (RLS 1, RLS2, and RLS3) have been mapped, but no gene has been identified as yet. RLS1 has been confirmed in families from three different populations. We conducted a family-based association study of 159 European RLS trios. The subjects were genotyped using microsatellite markers evenly covering the candidate regions on chromosomes 14q and 9p with an average intermarker distance of 1.1 cM. Transmission disequilibrium tests were used to analyze the data, and empirical P values were estimated by permutation testing. On chromosome 14q, a significant association (empirical P = 0.0033) was found with a haplotype formed by markers D14S1014 and D14S1017 when analyzing all families. On chromosome 9p, no significant association in the sample of all families and only marginally significant associations were detected, with a haplotype involving markers D9S1846-D9S171 in a subset of South European trios and with a haplotype at D9S156-D9S157 in a subset of Central European trios (P = 0.0086 and 0.0077, respectively). These results represent the first confirmation of these loci in a mixed European population. Variable results observed in families of different ethnic groups further corroborate the genetic complexity of RLS. (C) 2006 Movement Disorder Society.en
dc.sourceMovement Disordersen
dc.source.uri<Go to ISI>://WOS:000243944800010
dc.subjectrestless legs syndromeen
dc.subjectgeneticsen
dc.subjecttransmissionen
dc.subjectdisequilibrium testen
dc.subjectRLS1en
dc.subjectRLS2en
dc.subjectRLS3en
dc.subjectEXTENDED TRANSMISSION/DISEQUILIBRIUM TESTen
dc.subjectSUSCEPTIBILITY LOCUSen
dc.subjectCHROMOSOME 12Qen
dc.subjectPREVALENCEen
dc.subjectLINKAGEen
dc.subjectIDENTIFICATIONen
dc.subjectHETEROGENEITYen
dc.subjectCONFIRMATIONen
dc.subjectEPIDEMIOLOGYen
dc.subjectCRITERIAen
dc.subjectClinical Neurologyen
dc.titleFamily-based association study of the loci 2 and 3 in a European restless legs syndrome populationen
dc.typejournalArticleen


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