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dc.creatorHolliday, G. L.en
dc.creatorBairoch, A.en
dc.creatorBagos, P. G.en
dc.creatorChatonnet, A.en
dc.creatorCraik, D. J.en
dc.creatorFinn, R. D.en
dc.creatorHenrissat, B.en
dc.creatorLandsman, D.en
dc.creatorManning, G.en
dc.creatorNagano, N.en
dc.creatorO'Donovan, C.en
dc.creatorPruitt, K. D.en
dc.creatorRawlings, N. D.en
dc.creatorSaier, M.en
dc.creatorSowdhamini, R.en
dc.creatorSpedding, M.en
dc.creatorSrinivasan, N.en
dc.creatorVriend, G.en
dc.creatorBabbitt, P. C.en
dc.creatorBateman, A.en
dc.date.accessioned2015-11-23T10:30:08Z
dc.date.available2015-11-23T10:30:08Z
dc.date.issued2015
dc.identifier10.1002/prot.24803
dc.identifier.issn0887-3585
dc.identifier.urihttp://hdl.handle.net/11615/28500
dc.description.abstractAs the volume of data relating to proteins increases, researchers rely more and more on the analysis of published data, thus increasing the importance of good access to these data that vary from the supplemental material of individual articles, all the way to major reference databases with professional staff and long-term funding. Specialist protein resources fill an important middle ground, providing interactive web interfaces to their databases for a focused topic or family of proteins, using specialized approaches that are not feasible in the major reference databases. Many are labors of love, run by a single lab with little or no dedicated funding and there are many challenges to building and maintaining them. This perspective arose from a meeting of several specialist protein resources and major reference databases held at the Wellcome Trust Genome Campus (Cambridge, UK) on August 11 and 12, 2014. During this meeting some common key challenges involved in creating and maintaining such resources were discussed, along with various approaches to address them. In laying out these challenges, we aim to inform users about how these issues impact our resources and illustrate ways in which our working together could enhance their accuracy, currency, and overall value. Proteins 2015; 83:1005-1013. (c) 2015 The Authors. Proteins: Structure, Function, and Bioinformatics Published by Wiley Periodicals, Inc.en
dc.sourceProteins-Structure Function and Bioinformaticsen
dc.source.uri<Go to ISI>://WOS:000355138800001
dc.subjectspecialist protein resourceen
dc.subjectkey challengesen
dc.subjectbiocurationen
dc.subjectlongevityen
dc.subjectbigen
dc.subjectdataen
dc.subjectmisannotationen
dc.subjectFAMILIES DATABASEen
dc.subjectINFORMATIONen
dc.subjectKNOWLEDGEen
dc.subjectUPDATEen
dc.subjectCOLLECTIONen
dc.subjectDIVERSITYen
dc.subjectDISCOVERYen
dc.subjectSEQUENCESen
dc.subjectENZYMESen
dc.subjectBIOLOGYen
dc.subjectBiochemistry & Molecular Biologyen
dc.subjectBiophysicsen
dc.titleKey challenges for the creation and maintenance of specialist protein resourcesen
dc.typejournalArticleen


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