Adiponectin: a key playmaker adipocytokine in non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and can progress to cirrhosis, liver failure, and hepatocellular carcinoma. In the last two decades, the prevalence of NAFLD has been growing in most developed countries, mainly as a consequence of its close association with obesity and diabetes mellitus. The exact pathogenesis of NAFLD and especially the mechanisms leading to disease progression have not been completely understood. Adipocytes produce and secrete several bioactive substances known as adipocytokines which are implicated in the pathogenesis of the disease. Among them, adiponectin is an insulin-sensitizing adipocytokine possessing multiple beneficial effects on obesity-related medical complication. This review focuses on the role of adiponectin in NAFLD pathogenesis and its potential use as a diagnostic tool but also as therapeutic target for NAFLD management.
Showing items related by title, author, creator and subject.
Chalvatzas, N.; Dafopoulos, K.; Kosmas, G.; Kallitsaris, A.; Pournaras, S.; Messinis, I. E. (2009)Objective: To investigate the effect of ovarian hormones on adiponectin and resistin levels in women. Design: Experimental study. Setting: University hospital. Patient(s): Thirteen normally cycling women (7 in group I and ...
The Emerging Roles of Adiponectin in Female Reproductive System-Associated Disorders and Pregnancy Angelidis, G.; Dafopoulos, K.; Messini, C. I.; Valotassiou, V.; Tsikouras, P.; Vrachnis, N.; Psimadas, D.; Georgoulias, P.; Messinis, I. E. (2013)Adiponectin, the most abundant adipose-released cytokine, has an important role in metabolism, primarily through reducing insulin resistance. Reproductive functions are known to be influenced by energy balance and adiponectin ...
Association of Bone Mineral Density, Parameters of Bone Turnover, and Body Composition in Patients With Chronic Obstructive Pulmonary Disease Fountoulis, G. A.; Minas, M.; Georgoulias, P.; Fezoulidis, I. V.; Gourgoulianis, K. I.; Vlychou, M. (2012)Patients with chronic obstructive pulmonary disease (COPD) often develop osteoporosis. Many hormones regulate bone metabolism and body composition, and some of them are affected in COPD patients vs controls. In 46 COPD ...